BHAVYADHARSHINI ARUN^1,#, PRARTHANA GOPINATH^1,2,#, ANUP JHA^1,3, NISHTHA TRIPATHI¹, SYED G DASTAGER^4,*, SYED K HASAN^1,3,*

Oncology Research, Vol.33, No.8, pp. 2161-2174, 2025, DOI:10.32604/or.2025.062951 - 18 July 2025

Abstract Background: Acute Myeloid Leukemia (AML) is a highly aggressive clonal hematological malignancy with limited treatment options. This study aimed to evaluate the therapeutic potential of nigericin, a polyether ionophore derived from Streptomyces DASNCL-29, as a mitochondrial-targeted agent for AML treatment. Methods: Nigericin was isolated from Streptomyces DASNCL-29 and characterized via chromatography and NMR. Its cytotoxicity was tested in MOLM13 (sensitive and venetoclax-resistant) and HL60 (sensitive and cytarabine-resistant) cells using the MTT assay. Mitochondrial dysfunction was assessed by measuring reactive oxygen species (ROS), mitochondrial membrane potential (Δψm), and mitochondrial mass. Apoptosis was evaluated with Annexin V/PI assays… More > Graphic Abstract

Xuan Huo¹, Bingchen Wu¹, Yuanmeng Lou¹, Junlin Zhu¹, Cui Li¹, Lili Ma¹, Ye-Tang Pan², Chuncheng Hao^1,*, Xin Wen^1,*

Journal of Polymer Materials, Vol.42, No.2, pp. 517-530, 2025, DOI:10.32604/jpm.2025.065320 - 14 July 2025

Abstract Power cables are important pieces of equipment for energy transmission, but achieving a good balance between flame retardancy and mechanical properties of cable sheaths remains a challenge. In this work, a novel intumescent flame retardant (IFR) system containing silicone-containing macromolecular charring agent (Si-MCA) and ammonium polyphosphate (APP) was designed to synergistically improve the flame retardancy and mechanical properties of ethylene-butyl acrylate copolymer (EBA) composites. The optimal mass ratio of APP/Si-MCA was 3/1 in EBA composites (EBA/APP-Si-31), corresponding to the best flame retardancy with 31.2% of limited oxygen index (LOI), V-0 rating in UL-94 vertical burning More > Graphic Abstract

Rongbo Sun, Jinlong Fei^*, Yuefei Zhu, Zhongyu Guo

CMC-Computers, Materials & Continua, Vol.84, No.2, pp. 3765-3786, 2025, DOI:10.32604/cmc.2025.064849 - 03 July 2025

Abstract Moving Target Defense (MTD) necessitates scientifically effective decision-making methodologies for defensive technology implementation. While most MTD decision studies focus on accurately identifying optimal strategies, the issue of optimal defense timing remains underexplored. Current default approaches—periodic or overly frequent MTD triggers—lead to suboptimal trade-offs among system security, performance, and cost. The timing of MTD strategy activation critically impacts both defensive efficacy and operational overhead, yet existing frameworks inadequately address this temporal dimension. To bridge this gap, this paper proposes a Stackelberg-FlipIt game model that formalizes asymmetric cyber conflicts as alternating control over attack surfaces, thereby capturing More >

Chao Li^1,3,#, Quanzhi Feng^1,3,#, Caichang Ding^2,*, Zhiwei Ye^1,3

CMC-Computers, Materials & Continua, Vol.84, No.2, pp. 3605-3621, 2025, DOI:10.32604/cmc.2025.063703 - 03 July 2025

Abstract The increasing adoption of unmanned aerial vehicles (UAVs) in urban low-altitude logistics systems, particularly for time-sensitive applications like parcel delivery and supply distribution, necessitates sophisticated coordination mechanisms to optimize operational efficiency. However, the limited capability of UAVs to extract state-action information in complex environments poses significant challenges to achieving effective cooperation in dynamic and uncertain scenarios. To address this, we presents an Improved Multi-Agent Hybrid Attention Critic (IMAHAC) framework that advances multi-agent deep reinforcement learning (MADRL) through two key innovations. Firstly, a Temporal Difference Error and Time-based Prioritized Experience Replay (TT-PER) mechanism that dynamically adjusts… More >

Saurabh Sanjay Singh^*, Rahul Joshi, Deepak Gupta

Journal on Artificial Intelligence, Vol.7, pp. 177-203, 2025, DOI:10.32604/jai.2025.065078 - 30 June 2025

Abstract This paper addresses the challenge of energy-conscious scheduling in modern manufacturing by formulating and solving the Energy-Conscious Flexible Job Shop Scheduling Problem. In this problem, each job has a fixed sequence of operations to be performed on parallel machines, and each operation can be assigned to any capable machine. The problem statement aims to schedule every job in a way that minimizes the total energy consumption of the job shop. The paper’s primary objective is to develop a reinforcement learning-based scheduling framework using the Advantage Actor-Critic algorithm to generate energy-efficient schedules that are computationally fast… More >

Ghulam E Mustafa Abro^1,*, Altaf Mugheri^2,#, Zain Anwar Ali^3,#

Revue Internationale de Géomatique, Vol.34, pp. 301-331, 2025, DOI:10.32604/rig.2025.065595 - 05 June 2025

Abstract Swarm intelligence, derived from the collective behaviour of biological entities, is a novel methodology for overseeing satellite constellations within decentralized control systems. Conventional centralized control systems in satellite constellations encounter constraints in scalability, resilience, and fault tolerance, particularly in extensive constellations. This research examines the use of swarm-based multi-agent systems and distributed algorithms for efficient communication, collision avoidance, and collaborative task execution in satellite constellations. We provide a comprehensive study of current swarm control algorithms, their relevance to satellite systems, and identify areas requiring further research. Principal subjects encompass decentralized decision-making, self-organization, adaptive communication protocols, More >

Jiran Zhu¹, Silin He¹, Chun Chen^2,*, Li Zhou², Hongqing Li¹, Di Zhang¹, Fenglin Hua¹, Tianhao Zhu²

Energy Engineering, Vol.122, No.6, pp. 2465-2483, 2025, DOI:10.32604/ee.2025.065453 - 29 May 2025

Abstract In the islanded operation of distribution networks, due to the mismatch of line impedance at the inverter output, conventional droop control leads to inaccurate power sharing according to capacity, resulting in voltage and frequency fluctuations under minor external disturbances. To address this issue, this paper introduces an enhanced scheme for power sharing and voltage-frequency control. First, to solve the power distribution problem, we propose an adaptive virtual impedance control based on multi-agent consensus, which allows for precise active and reactive power allocation without requiring feeder impedance knowledge. Moreover, a novel consensus-based voltage and frequency control More >

Aamir Farooq¹, Zhengrong Xiang^1,*, Wen-Jer Chang^2,*, Muhammad Shamrooz Aslam³

CMC-Computers, Materials & Continua, Vol.83, No.3, pp. 3623-3674, 2025, DOI:10.32604/cmc.2025.063665 - 19 May 2025

Abstract Formation control in multi-agent systems has become a critical area of interest due to its wide-ranging applications in robotics, autonomous transportation, and surveillance. While various studies have explored distributed cooperative control, this review focuses on the theoretical foundations and recent developments in formation control strategies. The paper categorizes and analyzes key formation types, including formation maintenance, group or cluster formation, bipartite formations, event-triggered formations, finite-time convergence, and constrained formations. A significant portion of the review addresses formation control under constrained dynamics, presenting both model-based and model-free approaches that consider practical limitations such as actuator bounds,… More >

Ziyang Wang, Yuanzhen Feng^*, Zhengxin Wang, Cong Zheng

CMC-Computers, Materials & Continua, Vol.83, No.3, pp. 4835-4853, 2025, DOI:10.32604/cmc.2025.063179 - 19 May 2025

Abstract Continuous control protocols are extensively utilized in traditional MASs, in which information needs to be transmitted among agents consecutively, therefore resulting in excessive consumption of limited resources. To decrease the control cost, based on ISC, several LFC problems are investigated for second-order MASs without and with time delay, respectively. Firstly, an intermittent sampled controller is designed, and a sufficient and necessary condition is derived, under which state errors between the leader and all the followers approach zero asymptotically. Considering that time delay is inevitable, a new protocol is proposed to deal with the time-delay situation.… More >

Pamela Lippi¹, Aleš Eichmeier², Sergio Puccioni³, Giovan Battista Mattii¹, Eleonora Cataldo^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.4, pp. 1047-1072, 2025, DOI:10.32604/phyton.2025.064272 - 30 April 2025

Abstract The search for environmentally friendly approaches in viticulture is increasing, driven by the need to minimize the ecological footprint of conventional methods while ensuring high grape quality and stable yields. Among the various alternatives explored, essential oils (EOs) have drawn attention due to their natural origin and bioactive properties, including antimicrobial, antifungal, and insect-repellent effects. They are characterized by numerous utilisations, from managing diseases and pests in vineyards to post-harvest applications to preserve and prolong storage duration. This innovative review examines, for the first time, the topic of EOs on viticulture, embracing their multiple uses… More >