Tian-Tian Li^1,2,3,#, Ming-Yao Meng^1,2,4,#, Zheng Yu⁵, Yang-Fan Guo^1,2,4, Yi-Yi Zhao^1,2,4, Hui Gao^1,2,4, Li-Li Yang^1,2,3, Li-Rong Yang^1,2,3, Meng-Yuan Chu^1,2,3, Shan He^1,2,4, Yuan Liu^1,2,4, Xiao-Dan Wang^1,2,4, Wen-Ju Wang^1,2,4, Zong-Liu Hou^1,2,4, Li-Wei Liao^1,2,4,*, Lin Li^1,2,4,*

Oncology Research, Vol.33, No.11, pp. 3447-3467, 2025, DOI:10.32604/or.2025.065394 - 22 October 2025

Abstract Background: Chimeric antigen receptor T (CAR-T) cell therapies have demonstrated significant clinical efficacy in hematological malignancies. However, their application to solid tumors remains substantially limited by multiple challenges, including the risk of off-target effects. Hence, optimizing CAR-T cells for stronger antigen binding is essential. Methods: In this study, we employed a classical anti-human endothelial growth factor receptor 2 (HER2) single-chain variable fragment (scFv) derived from trastuzumab, alongside an anti-HER2-13 scFv identified from a combinatorial cellular CAR library, for the construction of a third-generation CAR-T cell. Meanwhile, the phenotypes and both in vitro and in vivo functions of… More > Graphic Abstract

Young Mae Ko, Tae Hyon Kim^*

BIOCELL, Vol.49, No.7, pp. 1141-1168, 2025, DOI:10.32604/biocell.2025.065464 - 25 July 2025

Abstract Ginsenosides, the bioactive saponins primary found in Panax ginseng, possess a complex structure that underlies their diverse pharmacological properties. Ginsenoside Rg3 stands out for its broad therapeutic potential, including anticancer, anti-inflammatory, neuroprotective, and cardiovascular effects. This review provides a comprehensive overview of the cellular and molecular mechanisms of Rg3, emphasizing its roles in regulating apoptosis, inflammation, oxidative stress, and metabolic pathways relevant to skincare and anticancer applications. The unique biological activities of its isomeric forms, 20(S)-Rg3 and 20(R)-Rg3, are highlighted, alongside strategies to enhance its bioavailability, such as nanoencapsulation and prodrug design. Additionally, the synergistic effects More >

HAFIZ MUHAMMAD REHMAN^1,2,*, SIDRA AHMAD², AZEEM SARWAR¹, HAMID BASHIR^2,*

Oncology Research, Vol.33, No.7, pp. 1547-1570, 2025, DOI:10.32604/or.2025.062197 - 26 June 2025

Abstract Targeted cancer therapy has emerged as a promising alternative to conventional chemotherapy, which is often plagued by poor selectivity, off-target effects, and drug resistance. Among the various targeting agents in development, peptides stand out for their unique advantages, including minimal immunogenicity, high tissue penetration, and ease of modification. Their small size, specificity, and flexibility allow them to target cancer cells while minimizing damage to healthy tissue selectively. Peptide-based therapies have shown great potential in enhancing the efficacy of drug delivery, improving tumor imaging, and reducing adverse effects. With cancer responsible for millions of deaths worldwide,… More >

JI-SU HAN¹, HYE-JIN BOO¹, JIN WON HYUN¹, HEESANG SONG², IN-YOUB CHANG³, SANG-PIL YOON^1,4,*

Oncology Research, Vol.33, No.4, pp. 873-884, 2025, DOI:10.32604/or.2024.052003 - 19 March 2025

Abstract Background: Chitosan oligosaccharide (COS) is the major degradation product of chitosan by enzymatic processes. COS, with complete water solubility, exerts significant biological effects, including anti-cancer activity. We investigated the anti-tumor effects of COS on colorectal cancer as effective therapeutic methods with low side effects are lacking. Methods: COS was obtained from low molecular weight chitosan by an enzymatic method and the anti-cancer effects were measured by cell viability assay, flow cytometry analysis, Western blotting, and xenograft. Results: COS suppressed the proliferation of SNU-C5 cells compared to other colorectal cancer cells, but higher concentrations were required in… More > Graphic Abstract

SUCHITRA NISHAL¹, VIKAS JHAWAT^1,*, SUMEET GUPTA², PARMITA PHAUGAT¹

Oncology Research, Vol.30, No.5, pp. 221-230, 2022, DOI:10.32604/or.2022.027549 - 03 February 2023

Abstract Kinase inhibitors are a significant and continuously developing division of target therapeutics. The drug discovery and improvement efforts have examined numerous attempts to target the signaling pathway of kinases. The Kinase inhibitors have been heralded as a game-changer in cancer treatment. For developing kinase inhibitors as a treatment for various non-malignant disorders like auto-immune diseases, is currently undergoing extensive research. It may be beneficial to investigate whether cell-specific kinase inhibitor administration enhances therapeutic efficacy and decreases adverse effects. The goal of the current review is to gain insight into the role of kinase inhibitors in… More >

POOJA JAISWAL¹, VERSHA TRIPATHI¹, ANSHUL ASSAIYA², DHARMENDRA KASHYAP³, RAHUL DUBEY⁴, ANAMIKA SINGH⁴, JANESH KUMAR², HEM CHANDRA JHA³, RAJESH SHARMA⁵, AMIT KUMAR DIXIT⁶, HAMENDRA SINGH PARMAR^1,*

BIOCELL, Vol.46, No.12, pp. 2645-2657, 2022, DOI:10.32604/biocell.2022.021754 - 10 August 2022

Abstract Triple-negative breast cancer (TNBC) cell line MDA-MB-231 is known for Warburg metabolism and defects in mitochondria. On the other hand, dipeptidyl peptidase-IV (DPP-IV) inhibitors such as sitagliptin and vildagliptin and GLP-1 agonist exendin-4 are known to improve mitochondrial functions as well as biogenesis, but no study has evaluated the influence of these drugs on mitochondrial biogenesis on metastatic breast cancer cell line. We have recently reported anticancer effects of 5-aminoimidazole-4-carboxamide riboside on MDA-MB-231 cells via activation of AMP-dependent kinase (AMPK), which activates the downstream transcription factors PGC-1α, PGC-1β, or FOXO1 for mitochondrial biogenesis; above-mentioned incretin-based… More >

Chunya Hu, Yu He^*

Oncologie, Vol.23, No.2, pp. 241-250, 2021, DOI:10.32604/Oncologie.2021.015828 - 22 June 2021

Abstract Objective: The aim of the present study was to investigate the anti-tumor effects of formononetin on human nonsmall cell lung cancer (NSCLC) and its potential molecular mechanism. Methods: A549 cells were treated with different concentrations of formononetin, then detected the cell proliferation, apoptosis and the expression of HIPK2 respectively by MTT assay, flow cytometry analysis and RT-qPCR. Then the interaction between miR- 27a-3p and its target gene HIPK2 was verified through luciferase reporter assay. The expression of miR-27a- 3p, HIPK2, and p53 was detected after being treated with different formononetin concentrations by RT-qPCR and western blot. Results: More >

Jaswinder Kaur¹, Manish Vyas², Joginder Singh¹, Ram Prasad^3,*, Jeena Gupta^1,*

Phyton-International Journal of Experimental Botany, Vol.89, No.4, pp. 795-803, 2020, DOI:10.32604/phyton.2020.09420 - 09 November 2020

Abstract In recent years, there has been an increase in epidemiological studies to highlight the health benefits of plant secondary metabolites. Flavonoids (polyphenolic plant secondary metabolites) are recently emerging as an important source for the discovery of new drugs increasing their pharmaceuticals, nutraceutical and medicinal applications. Naringenin is a flavanone, enriched in citrus fruits, tomatoes, bergamot, etc. which has been evaluated extensively for managing diabetes. However, in addition to this, naringenin had been ascribed to various important biological activities like antioxidant, antiviral, anticancer, anti-inflammatory, antiestrogenic, etc. This article aims at highlighting the therapeutic value of naringenin More >

Kena Lv¹, Shuangshuang Zheng², Xiangqin Li¹, Yi Nie^2,3,*, Tianqing Liu¹, Kedong Song^1,*

Molecular & Cellular Biomechanics, Vol.17, No.4, pp. 199-204, 2020, DOI:10.32604/mcb.2020.011811 - 20 October 2020

Abstract As one of the adjuvant treatments for cancer treatment, traditional Chinese medicine treatment has a wide range of cancer treatments, such as preventing metastasis and relapse, improving the efficacy of radiotherapy and chemotherapy, reducing the side effects of chemotherapy, improving body function, extending life and improving the life quality. Geniposide (GEN) is a bioactive substance extracted from the fruit of gardenia. In recent years, it has attracted attention due to its anti-tumor effect. In this study, we aimed to investigate whether GEN could inhibit the proliferation of human breast cancer cells (MCF-7) and promote its More >