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  • Open Access

    ARTICLE

    Reliability of Echocardiographic Pulmonary Vascular Resistance to Screen for the New Definition of Precapillary Pulmonary Hypertension in Uncorrected Secundum Atrial Septal Defect

    Risalina Myrtha1,2,*, Hasanah Mumpuni3,4, Real Kusumanjaya Marsam3,4, Dyah Wulan Anggrahini3,4, Anggoro Budi Hartopo3,4, Lucia Kris Dinarti3,4

    Congenital Heart Disease, Vol.19, No.3, pp. 315-324, 2024, DOI:10.32604/chd.2024.051587 - 26 July 2024

    Abstract Background and Objective: The most feared complication of uncorrected secundum Atrial Septal Defect (ASD) is pulmonary arterial hypertension (PAH). Pulmonary vascular resistance (PVR) is crucial in detecting precapillary pulmonary hypertension (PH) to guide the need for PAH-specific therapy. There is a change in the cut-off value of PVR according to the recently updated PH guideline. How echocardiographic PVR (PVR) correlates to PVR by right heart catheterization (RHC) (PVR) according to the new guidelines has not been known. The aim of this study is to determine the reliability of PVR in detecting PAH in Uncorrected Ostium… More > Graphic Abstract

    Reliability of Echocardiographic Pulmonary Vascular Resistance to Screen for the New Definition of Precapillary Pulmonary Hypertension in Uncorrected Secundum Atrial Septal Defect

  • Open Access

    ARTICLE

    Transcatheter Closure of Postoperative Residual Atrial or Ventricular Septal Shunts in Patients with Congenital Heart Disease

    Jiawang Xiao, Jianming Wang, Zhongchao Wang, Lili Meng, Ming Zhao, Qiguang Wang*

    Congenital Heart Disease, Vol.19, No.3, pp. 293-303, 2024, DOI:10.32604/chd.2024.051427 - 26 July 2024

    Abstract Background: Transcatheter closure (TCC) has emerged as the preferred treatment for selected congenital heart disease (CHD). While TCC offers benefits for patients with postoperative residual shunts, understanding its mid- and long-term efficacy and safety remains crucial. Objective: This study aims to assess the mid- and long-term safety and efficacy of TCC for patients with residual atrial or ventricular septal shunts following CHD correction. Methods: In this consecutive retrospective study, we enrolled 35 patients with residual shunt who underwent TCC or surgical repair of CHD between June 2011 to October 2022. TCC candidacy was determined based on… More >

  • Open Access

    ARTICLE

    Deep Learning-Based ECG Classification for Arterial Fibrillation Detection

    Muhammad Sohail Irshad1,2,*, Tehreem Masood1,2, Arfan Jaffar1,2, Muhammad Rashid3, Sheeraz Akram1,2,4,*, Abeer Aljohani5

    CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 4805-4824, 2024, DOI:10.32604/cmc.2024.050931 - 20 June 2024

    Abstract The application of deep learning techniques in the medical field, specifically for Atrial Fibrillation (AFib) detection through Electrocardiogram (ECG) signals, has witnessed significant interest. Accurate and timely diagnosis increases the patient’s chances of recovery. However, issues like overfitting and inconsistent accuracy across datasets remain challenges. In a quest to address these challenges, a study presents two prominent deep learning architectures, ResNet-50 and DenseNet-121, to evaluate their effectiveness in AFib detection. The aim was to create a robust detection mechanism that consistently performs well. Metrics such as loss, accuracy, precision, sensitivity, and Area Under the Curve… More >

  • Open Access

    ARTICLE

    Impact of Atrial Septal Defect Closure on Mortality in Older Patients

    Sipawath Khamplod1,2, Yodying Kaolawanich1,2, Khemajira Karaketklang3, Nithima Ratanasit1,2,*

    Congenital Heart Disease, Vol.19, No.1, pp. 93-105, 2024, DOI:10.32604/chd.2024.048631 - 20 March 2024

    Abstract Background: Atrial septal defect (ASD) is a common form of adult congenital heart disease that can lead to long-term adverse outcomes if left untreated. Early closure of ASD has been associated with excellent outcomes and lower complication rates. However, there is limited evidence regarding the prognosis of ASD closure in older adults. This study aims to evaluate the mortality rates in older ASD patients with and without closure. Methods: A retrospective cohort study was conducted on patients aged 40 years or older with ASD between 2001 and 2017. Patients were followed up to assess all-cause… More > Graphic Abstract

    Impact of Atrial Septal Defect Closure on Mortality in Older Patients

  • Open Access

    ARTICLE

    The Effect of Atrial Septal Defect Closure on Cardiac Volumetric Changes in Adults, Transcatheter Versus Surgical Closure, a Pilot Cardiac Magnetic Resonance Study

    Amr Mansour1, Noha M. Gamal2,*, Alaa M. Nady3, Amr Ibraheem3, Dalia M. Salah4, Khaled M. El-Maghraby2

    Congenital Heart Disease, Vol.18, No.6, pp. 679-691, 2023, DOI:10.32604/chd.2023.020028 - 19 January 2024

    Abstract Background: Closure of an atrial septal defect (ASD) reduces right-side heart volumes by abolishing shunting with simultaneous improvement of the left ventricle (LV) filling and functions due to ventricular interdependence, thereby improving symptoms. Furthermore, studies conducted on atrial volume changes after ASD closure are limited. Cardiac magnetic resonance (CMR) is considered as the gold standard method for measuring cardiac volume and mass. Objective: We aimed to study the effect of transcatheter and surgical closure of secundum ASD on cardiac volumes and systolic functions as well as the fate of tricuspid regurgitation (TR), using CMR analysis. Methods:More >

  • Open Access

    ARTICLE

    Anatomic Correlates of Mitral Systolic Anterior Motion in Transposition of the Great Arteries Following Atrial Switch Operation

    Norman Aiad1,2,3,7, Mark V. Sherrid1,7, Adam J. Small1, Youssef Elnabawi1,7, Jodi Feinberg1, Leon Axel1,4, Ralph Mosca5, T. K. Susheel Kumar5, Michael Argilla6, Dan G. Halpern1,7,*

    Congenital Heart Disease, Vol.18, No.3, pp. 267-277, 2023, DOI:10.32604/chd.2023.025853 - 09 June 2023

    Abstract Introduction: We sought to investigate whether the development of sub-pulmonic systolic anterior motion (SAM) may be inherent to the anatomy of the the mitral valve (MV) or affected by external factors, such as a dilated right ventricle or chest abnormalities in d-looped transposition of the great arteries post atrial switch operation (d-TGA/AtS). Methods: Analysis was performed of clinical and cardiac imaging studies acquired on 19 adult patients with d-TGA/AtS (age 42 ± 6 years old, 56% male) between 2015–2019. Echocardiography data included mitral apparatus anatomy, and CT/MRI data included biventricular dimensions, function, and Haller index… More >

  • Open Access

    CASE REPORT

    “Treat-Repair-Treat”: Management of Left Main Coronary Compression by a Pulmonary Artery Aneurysm in a Patient with Atrial Septal Defect and Significant Pulmonary Hypertension

    Andrei George Iosifescu1,2,*, Roxana Enache1,3, Ioana Marinică4, Corina Radu2, Vlad Anton Iliescu1,2

    Congenital Heart Disease, Vol.18, No.1, pp. 67-72, 2023, DOI:10.32604/chd.2023.026598 - 09 January 2023

    Abstract Left main coronary compression syndrome (LMCS) may complicate pulmonary artery aneurysms (PAA), usually developed in the context of pulmonary arterial hypertension (PAH). We report the case of a 51-year-old female patient with an atrial septal defect (unsuitable for device closure) complicated by a PAA generating a 90% left main stenosis. The significant PAH held us back from immediate surgery. After specific dual PAH-targeted therapy (sildenafil and bosentan), the atrial septal defect could be closed with a unidirectional valved patch; the PAA-induced LMCS was treated by reductive arterioplasty. The postoperative course was uneventful. Follow-up showed clinical More > Graphic Abstract

    “Treat-Repair-Treat”: Management of Left Main Coronary Compression by a Pulmonary Artery Aneurysm in a Patient with Atrial Septal Defect and Significant Pulmonary Hypertension

  • Open Access

    CASE REPORT

    Emergency Hybrid Correction in a Newborn with Critical Aortic Valve Stenosis with Acute Pulmonary Edema in the First Hour after Birth

    Vitaliy Suvorov*, Vladimir Zaitsev, Nikolay Pilyugov, Olga Tereshenko, Michail Komissarov

    Congenital Heart Disease, Vol.18, No.1, pp. 57-65, 2023, DOI:10.32604/chd.2023.025522 - 09 January 2023

    Abstract Critical aortic valve stenosis in newborns is the cause of a severe clinical condition with the onset of symptoms during first hours after birth. We present a clinical case of a successful surgical correction of a critical aortic stenosis using a hybrid method applied in a newborn during the first day of life. The infant was diagnosed with a hypoplastic left heart complex with an intact atrial septum (aortic and mitral valves stenosis variant), that led to the cardiogenic shock and acute pulmonary edema. The procedure included bilateral banding of the pulmonary artery branches and More > Graphic Abstract

    Emergency Hybrid Correction in a Newborn with Critical Aortic Valve Stenosis with Acute Pulmonary Edema in the First Hour after Birth

  • Open Access

    ARTICLE

    Classifying Cardiac Anomalies in Right and Left Isomerism: Concordant and Discordant Patterns

    Lilia Oreto1,*, Giuseppe Mandraffino2, Paolo Ciliberti3, Teresa P. Santangelo4, Placido Romeo5, Antonio Celona5, Placido Gitto1, Lorenzo Galletti3, Fiore S. Iorio3, Alfredo Di Pino1, Aurelio Secinaro4, Paolo Guccione3, Robert H. Anderson6, Salvatore Agati1

    Congenital Heart Disease, Vol.18, No.1, pp. 97-111, 2023, DOI:10.32604/chd.2022.023619 - 09 January 2023

    Abstract Aims: Evidence is emerging that, in the setting of isomerism, the atrial and bronchial arrangement are not always concordant, nor are these patterns always harmonious with the arrangement of the abdominal organs. We aimed to evaluate the concordance between these features in a cohort of patients with cardiac malformations in the setting of known isomerism, seeking to determine whether it was feasible to assess complexity on this basis, in this regard taking note of the potential value of bronchial as opposed to appendage morphology. Methods and Results: We studied 78 patients known to have isomerism of the… More > Graphic Abstract

    Classifying Cardiac Anomalies in Right and Left Isomerism: Concordant and Discordant Patterns

  • Open Access

    ARTICLE

    Genetic Analysis of Variants of the MYH6 Gene Promoter in Congenital Atrial Septal Defects

    Ji-Yang Zuo1,2, Huan-Xin Chen1,2, Zhi-Gang Liu1,2, Qin Yang1,2, Guo-Wei He1,2,*

    Congenital Heart Disease, Vol.18, No.1, pp. 7-21, 2023, DOI:10.32604/chd.2022.025451 - 09 January 2023

    Abstract Background: Atrial septal defect (ASD) is one of the common congenital heart diseases. The MYH6 gene has a critical role in cardiac development but the role of MYH6 promoter variants in patients with ASD has not been explored. Methods: In 613 subjects including 320 ASD patients, we investigated the MYH6 gene promoter variants and verified the effect on gene expression by using cellular functional experiments and bioinformatics analysis. Results: Eleven variants were identified in the MYH6 gene promoter, of which four variants were found only in ASD patients, and two variants (g.3434G>C and g.4524C>T) were identified for the first… More > Graphic Abstract

    Genetic Analysis of Variants of the <i>MYH6</i> Gene Promoter in Congenital Atrial Septal Defects

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