LUCIANA MAZZEI¹, ISABEL MERCEDES GARCÍA¹, VALERIA CACCIAMANI¹, MARÍA EUGENIA BENARDÓN¹ AND WALTER MANUCHA^{1, 2, 3}

BIOCELL, Vol.34, No.3, pp. 121-132, 2010, DOI:10.32604/biocell.2010.34.121

Abstract Wilms tumor gene 1 (wt-1), a key regulator of mesenchymal-epithelial transformation, is downregulated during congenital obstructive nephropathy, leading to apoptosis. There is a functional interaction between WT-1 and inducible nitric oxide synthase (iNOS). In this regard, we reported that after neonatal unilateral ureteral obstruction, rosuvastatin prevents apoptosis through an increase in nitric oxide bioavailability, which in turn is linked to higher Hsp70 expression. Hence, the goal of this study was to determine whether a nitric oxide/Hsp70 interaction is involved in changes in WT-1 mRNA expression after ureteral obstruction. Neonatal rats submitted to experimental ureteral obstruction were treated with either vehicle… More >

F. J. Bellomo¹, S. Oller², F. Armero³, L. G. Nallim¹

CMES-Computer Modeling in Engineering & Sciences, Vol.80, No.1, pp. 1-22, 2011, DOI:10.3970/cmes.2011.080.001

Abstract Some of the key factors that regulate growth and remodeling of tissues are fundamentally mechanical. However, it is important to take into account the role of biological availability to generate new tissue together with the stresses and strains in the processes of natural or pathological growth. In this sense, the model presented in this work is oriented to describe growth of vascular tissue under "stress driven growth" considering biological availability of the organism. The general theoretical framework is given by a kinematic formulation in large strain combined with the thermodynamic basis of open systems. The formulation uses a multiplicative decomposition… More >