KARAN WADHWA¹, PAYAL CHAUHAN¹, SHOBHIT KUMAR², RAKESH PAHWA^3,*, RAVINDER VERMA⁴, RAJAT GOYAL⁵, GOVIND SINGH¹, ARCHANA SHARMA⁶, NEHA RAO³, DEEPAK KAUSHIK^1,*

Oncology Research, Vol.32, No.5, pp. 877-897, 2024, DOI:10.32604/or.2024.047278

Abstract Background: Glioblastoma multiforme (GBM) is recognized as the most lethal and most highly invasive tumor. The high likelihood of treatment failure arises from the presence of the blood-brain barrier (BBB) and stem cells around GBM, which avert the entry of chemotherapeutic drugs into the tumor mass. Objective: Recently, several researchers have designed novel nanocarrier systems like liposomes, dendrimers, metallic nanoparticles, nanodiamonds, and nanorobot approaches, allowing drugs to infiltrate the BBB more efficiently, opening up innovative avenues to prevail over therapy problems and radiation therapy. Methods: Relevant literature for this manuscript has been collected from a comprehensive and systematic search of… More > Graphic Abstract

HUAN HU^1,2,*, YUE HUANG¹, FANGZHOU LIU¹, QIAN WANG^1,2, YANZI YAO^3,*

BIOCELL, Vol.48, No.3, pp. 353-362, 2024, DOI:10.32604/biocell.2024.048311

Abstract Increasing life expectancy and an aging population lead to age-related bone diseases like osteoporosis and low bone mass more prevalent. These conditions represent a common, costly and chronic burden, not only for elderly but also to society at large. Consequently, elucidating the pathophysiology and developing effective therapies for these diseases is of paramount importance. Recent advances in research have identified the gut as a novel and promising target for addressing bone disorders, giving rise to the concept of the “gut-bone axis”. An in-depth review of the latest insights into the effects of age-related physiological changes in the gastrointestinal tract on… More >

Yu Huang¹, Beilei Liu¹, Dianlei Feng^2,*, Hao Shi¹

CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.2, pp. 1679-1699, 2024, DOI:10.32604/cmes.2023.044094

Abstract Rigid barrier deflectors can effectively prevent overspilling landslides, and can satisfy disaster prevention requirements. However, the mechanisms of interaction between natural granular flow and rigid barrier deflectors require further investigation. To date, few studies have investigated the impact of deflectors on controlling viscous debris flows for geological disaster prevention. To investigate the effect of rigid barrier deflectors on impact mechanisms, a numerical model using the smoothed particle hydrodynamics (SPH) method with the Herschel–Bulkley model is proposed to simulate the interaction between natural viscous flow and single/dual barriers with and without deflectors. This model was validated using laboratory flume test data… More > Graphic Abstract

Xuhang Lin¹, Haibo Chen^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.1, pp. 1-1, 2023, DOI:10.32604/icces.2023.09388

Abstract As an important and useful tool for reducing noise, the sound barrier is of practical significance. The sound barrier has different noise reduction effects for different sizes, shapes and properties of the sound absorbing material. Liu et al. [1] have performed shape optimization of sound barriers by using isogeometric boundary element method and method of moving asymptotes (MMA). However, in engineering practice, it is difficult to determine some parameters accurately such as material properties, geometries, external loads. Therefore, it is necessary to consider these uncertainty conditions in order to ensure the rationality of the numerical calculation of engineering problems. In… More >

Pan Li¹, Xiaochao Jin¹, Pin Lv¹, Xueling Fan^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.26, No.1, pp. 1-1, 2023, DOI:10.32604/icces.2023.010540

Abstract Refurbishment of thermal barrier coating (TBC) has become a valuable technique to prolong the service life of high-temperature components. In this work, the effect of refurbishment process on the oxidation behaviors of TBC was investigated. Before recoating, the soft chemical stripping method was used to remove TBC from DD6 single-crystal superalloy. The results showed that a certain amount of IDZ layer with Cr-rich would be retained in the DD6 superalloy substrate after coating removal. The characteristics of the β phases change from the elongated grain shapes and a high aspect ratio in the ordinary specimens to the equiaxed shape in… More >

LONGSHENG FU¹, JINFANG HU¹, FENG SHAO², YAOQI WU¹, WEI BAI³, MINGJIN JIANG³, HAO CHEN⁴, LIHUA CHEN², YANNI LV^1,*

BIOCELL, Vol.47, No.8, pp. 1869-1883, 2023, DOI:10.32604/biocell.2023.028602

Abstract Background: Biochanin A is an excellent dietary isoflavone that has the concomitant function of both medicine and foodstuff. The attenuation function of biochanin A on blood-brain barrier (BBB) damage induced by cerebral ischemia-reperfusion remains unclear. Methods: C57BL/6 mice were subjected to 1 h middle cerebral artery occlusion (MCAO) followed by 24 h reperfusion. The infarct volume of the brain was stained by TTC, while leakage of the brain was quantitatively stained by Evans blue, and the neurologic deficit score was measured. Microglial-induced morphologic changes were observed via immunofluorescence staining, and rolling and adhering leukocytes in venules were observed via two-photon… More >

Junling Qiu^*, Huihui Sun, Shuya Wang

CMES-Computer Modeling in Engineering & Sciences, Vol.137, No.3, pp. 2077-2109, 2023, DOI:10.32604/cmes.2023.027353

Abstract As indispensable components of superconducting circuit-based quantum computers, Josephson junctions determine how well superconducting qubits perform. Reverse Monte Carlo (RMC) can be used to recreate Josephson junction’s atomic structure based on experimental data, and the impact of the structure on junctions’ properties can be investigated by combining different analysis techniques. In order to build a physical model of the atomic structure and then analyze the factors that affect its performance, this paper briefly reviews the development and evolution of the RMC algorithm. It also summarizes the modeling process and structural feature analysis of the Josephson junction in combination with different… More >

Muzi Li^*

CMES-Computer Modeling in Engineering & Sciences, Vol.137, No.3, pp. 2465-2493, 2023, DOI:10.32604/cmes.2023.026827

Abstract Modular construction as an innovative method aids the construction industry in transforming to off-site construction production with high efficiency and environmental friendliness. Despite the obvious advantages, the uptake of modular construction is not booming as expected. However, previous studies have investigated and summarized the barriers to the adoption of modular construction. In this research, a Large-Scale Group Decision Making (LSGDM)- based analysis is first made of the severity of barriers to modular construction adoption from the perspective of construction stakeholders. In addition, the Technology-Organization-Environment (TOE) framework is utilized to identify the barriers based on three contexts (technology, organization, and environment).… More >

Mojtaba Kordrostami¹, Ali Akbar Ghasemi-Soloklui¹, Mohammad Anwar Hossain^2,*, Mohammad Golam Mostofa^3,4,*

Phyton-International Journal of Experimental Botany, Vol.92, No.9, pp. 2713-2736, 2023, DOI:10.32604/phyton.2023.030372

Abstract Numerous plant species, particularly those that can accumulate selenium (Se) and silicon (Si), benefit from these essential micronutrients. Se and Si accumulation in plants profoundly affects several biochemical reactions in cells. Understanding how plants react to Se/Si enrichment is crucial for ensuring adequate dietary Se/Si intake for humans and animals and increasing plant tolerance to environmental stressors. Several studies have shown that Se/Si-enriched plants are more resistant to salinity, drought, extreme temperatures, UV radiation, and excess metalloids. The interplay between Se/Si in plants is crucial for maintaining growth and development under normal conditions while providing a critical defense mechanism against… More >

Kevin W. Irick^*

Frontiers in Heat and Mass Transfer, Vol.8, pp. 1-7, 2017, DOI:10.5098/hmt.8.2

Abstract The Single-sided Guarded Hot Plate Method for Comparative Testing of Thermal Radiation Barriers in Vacuum was used to evaluate the performance of a variety of aerogel insulation specimens manufactured by Aspen Aerogels® against one another and against multi-layer insulation (MLI). Testing at the Air Force Research Laboratory (AFRL) shows that the effective thermal resistance, R_e, of all tested aerogel specimens are virtually bounded by the performance of 5-layer and 10-layer MLI specimens over a mean specimen temperature, T_m, range of about 270K to 315K. More >