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  • Open Access


    Isolation, purification and structure elucidation of three new bioactive secondary metabolites from Streptomyces lividans AM


    BIOCELL, Vol.45, No.5, pp. 1263-1271, 2021, DOI:10.32604/biocell.2021.013198

    Abstract Microorganisms are a huge mine of bioactive metabolites, and actinomycetes are one of the very active groups in this area. In this article, we are concerned about the full taxonomical characterization of Streptomyces lividans AM, isolated from Egyptian soil. This isolate produced three new bioactive metabolites, namely: 1-Nona-decanoyl,4-oleyl disuccinate (1), filoboletic acid; (9Z,11E)-8,13-dihydroxy octadeca-9,11-dienoic acid (2), and sitosteryl-3β-D-glucoside (3). Extensive 1D and 2D NMR and HR-mass spectrometry were used to elucidate the structures of the three compounds. Moreover, ten known compounds were also identified. The antimicrobial activity of the producing organism and newly reported compounds (1–3) was investigated against a… More >

  • Open Access


    Carotenoids: New Applications of “Old” Pigments

    Stefan M. Kolašinac1, Zora P. Dajić Stevanović1,*, Sofija N. Kilibarda1,  Aleksandar Ž. Kostić2,*

    Phyton-International Journal of Experimental Botany, Vol.90, No.4, pp. 1041-1062, 2021, DOI:10.32604/phyton.2021.015996

    Abstract Carotenoids represent a large group of mainly red, orange, and yellow natural metabolites mainly involved in regulation of many metabolic processes. Carotenoids are beneficial for human health. Current study describes the importance, chemical composition and functioning of carotenoids. It is well known that carotenoids support pigments acting in light absorbance mechanisms during photosynthesis, and are known to protect the chlorophyll molecules from oxidative stress and reactive oxygen species (ROS) damage. Carotenoids are involved in signaling processes in plants, responses to environmental stresses, pollination, germination and reproduction, and development regulation. As nutrients of strong antioxidant activity that is primarily linked to… More >

  • Open Access


    Safflower (Carthamus Tinctorius L.) a Potential Source of Drugs against Cryptococcal Infections, Malaria and Leishmaniasis

    Aknur Turgumbayeva1,2, Gulbaram Ustenova1, Ubaidilla Datkhayev1, Khairolla Rahimov3, Silvijus Abramavicius4,5, Agile Tunaityte4,*, Kairat Zhakipbekov1,6, Kaldanay Kozhanova1, Saken Tulemissov7, OzikhanUstenova8, Gulmira Datkayeva9, Edgaras Stankevicius1,10

    Phyton-International Journal of Experimental Botany, Vol.89, No.1, pp. 137-146, 2020, DOI:10.32604/phyton.2020.07665

    Abstract In this research we present that Carthamus Tinctorius L. (gen. Asteraceae, otherwise known as Safflower) (Fig. 1) may contain agents active in Cryptococcal infections, malaria and Leishmaniasis, as treatment options are becoming scarce due to drug resistance development. Phytochemistry and pharmacological activities (antimicrobial, antimalarial, antileishmanial) of C. tinctorius L. were analyzed. The composition of volatile oil of safflower dried flowers was analyzed by gas chromatography-mass spectrophotometry with flame ionization detector (GC-FID) and in vitro sensitivity assays were performed to assess biological activity. 8 known and 3 unknown compounds were detected in the extract (Fig. 1). Then the Safflower ointment was… More >

  • Open Access


    Construction and application of a yeast expression system for thymosin α1


    BIOCELL, Vol.29, No.3, pp. 253-259, 2005, DOI:10.32604/biocell.2005.29.253

    Abstract We want to construct a yeast expression system for thymosin α1 (Tα1) to make the orally administered Tα1 preparation possible. The whole Tα1 DNA fragment was obtained by PCR. After being digested with restriction enzymes, it was cloned into pYES2 vector. Sequencing was performed to identify the recombinant. The sequence of Tα1 in recombinant coincided with the original one reported in Genbank. When pYES2-Tα1 plasmid was transformed into yeast, galactose instead of glucose was used to induce Tα1 expression. Western blot was performed to identify the quality of the expressed Tα1. Dried yeast containing pYEST2-Tα1 was fed to Balb/c mice… More >

  • Open Access


    Biological activity of phototoxic compounds in Bidens squarrosa H.B.K. (Asteraceae)

    Pérez-Amador1 MC, V Muñoz Ocotero1, F García Jiménez2

    Phyton-International Journal of Experimental Botany, Vol.77, pp. 103-111, 2008, DOI:10.32604/phyton.2008.77.103

    Abstract Phototoxic compounds (polyacetylenes and thiophenes) and their biological activity were determined on Bidens squarrosa plants by measuring their antibacterial and anti-inflammatory potential. Phototoxic compounds were extracted with hexane, characterized by TLC, and their presence confirmed by U.V. spectrum of their extracts and bactericidal potential. Antibacterial activity of the hexane, ethyl acetate and methanol extracts was measured against Bacillus subtilis and Escherichia coli, and their antiinflammatory potential was determined by the mouse ear edema test. More >

  • Open Access


    Phototoxic compounds and biological activity of extracts from Eupatorium morifolium Mill. (Asteraceae)

    Pérez-Amador1 MC, V Muñoz Ocotero1, F García Jiménez2

    Phyton-International Journal of Experimental Botany, Vol.77, pp. 21-29, 2008, DOI:10.32604/phyton.2008.77.021

    Abstract Leaves of Eupatorium morifolium Mill. were analyzed for phototoxic compounds, and the toxicity of their hexane extract was evaluated against Bacillus subtilis. The phototoxic compounds were analyzed by TLC. In the plate, pale blue spots indicated the presence of these compounds. This was confirmed by the UV extract spectrum and the antibacterial activity against Bacillus subtilis. The biological activity of the leaf extracts (hexane, ethyl acetate or methanol) was also studied. The antiinflammatory activity was determined using the edema test on mouse ears, and the bactericide activity was assayed against Bacillus subtilis and Escherichia coli. A strong anti-inflammatory activity was… More >

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