Mingzhi Luo¹, Kai Ni¹, Peili Yu¹, Yang Jin², Lei Liu¹, Jingjing Li¹, Yan Pan¹, Linhong Deng^1,*

Molecular & Cellular Biomechanics, Vol.16, No.2, pp. 141-151, 2019, DOI:10.32604/mcb.2019.06756

Abstract Airway hyperresponsiveness (AHR) is the cardinal character of asthma, which involves the biomechanical properties such as cell stiffness and traction force of airway smooth muscle cells (ASMCs). Therefore, these biomechanical properties comprise logical targets of therapy. β2-adrenergic agonist is currently the mainstream drug to target ASMCs in clinical practice for treating asthma. However, this drug is known for side effects such as desensitization and non-responsiveness in some patients. Therefore, it is desirable to search for new drug agents to be alternative of β2-adrenergic agonist. In this context, sanguinarine, a natural product derived from plants such… More >

Masaki Izawa¹, Ryota Araki¹, Tatsuro Suzuki¹, Kaito Watanabe², Kazuhito Misaji^3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.118, No.3, pp. 493-507, 2019, DOI:10.31614/cmes.2019.04470

Abstract Primary purpose of this research is to create a three-dimensional musculoskeletal mathematical model of a driver of a car using a motion capture system. The model is then used in an analysis of drive torque around joints and attached muscles as a vehicle travels in different travel modes and damping force settings to examine ‘burdens’ for the driver. Previous studies proposed a method of quantifying the degree of musculoskeletal load in simple human motion from the changes in drive torque around joints and attached muscles. However, examination of the level of burdens for the driver More >

Dalin Tang^1,2,*, Zhiyong Li¹

CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 109-113, 2018, DOI:10.31614/cmes.2018.04201

Abstract This article has no abstract. More >

Jiangguo Lin¹, Botao Xiao^1,2, Quhuan Li¹, Ying Fang¹, Jianhua Wu^1,*

Molecular & Cellular Biomechanics, Vol.15, No.1, pp. 37-49, 2018, DOI:10.3970/mcb.2018.015.037

Abstract The protein structure-function paradigm implies that the structure of a protein defines its function. Crystallization techniques such as X-ray, electron microscopy (EM) and nuclear magnetic resonance (NMR) have been applied to resolve the crystal structure of numerous proteins, provided beautiful and informative models of proteins. However, proteins are not intrinsically in static state but in dynamic state, which is lack in crystal models. The protein flexibility, a key mechanical property of proteins, plays important roles in various biological processes, such as ligand-receptor interaction, signaling transduction, substrate recognition and post-translational modifications. Advanced time-resolved crystallography has been More >

Tushar Kulkarni¹, Dr. Rashmi Uddanwadiker²

Molecular & Cellular Biomechanics, Vol.13, No.2, pp. 87-104, 2016, DOI:10.3970/mcb.2016.013.099

Abstract This paper aims to determine the force required for holding the objects by human hand. A static analysis is performed on mathematical models to obtain holding force considering lower arm as class three lever and by varying the joint angles. Three mathematical models are discussed to quantify the force required to hold any object, for different weight of the object and the joint angles. A noninvasive experimentation using surface electromyogram was performed to determine the forces required by human hand for the same objects used in the mathematical modeling. Twenty-one male subjects participated in this… More >

S.F. Moreira^∗, J. Belinha^{∗,† ,‡}, L.M.J.S. Dinis^∗,†, R.M. Natal Jorge^∗,†

Molecular & Cellular Biomechanics, Vol.11, No.3, pp. 151-184, 2014, DOI:10.3970/mcb.2014.011.151

Abstract In this work the maxillary central incisor is numerically analysed with an advance discretization technique – Natural Neighbour Radial Point Interpolation Method (NNRPIM). The NNRPIM permits to organically determine the nodal connectivity, which is essential to construct the interpolation functions. The NNRPIM procedure, based uniquely in the computational nodal mesh discretizing the problem domain, allows to obtain autonomously the required integration mesh, permitting to numerically integrate the differential equations ruling the studied physical phenomenon. A numerical analysis of a tooth structure using a meshless method is presented for the first time. A two-dimensional model of More >

K. Y. Volokh^*

Molecular & Cellular Biomechanics, Vol.10, No.2, pp. 107-135, 2013, DOI:10.3970/mcb.2013.010.107

Abstract The application of mechanics to biology – biomechanics – bears great challenges due to the intricacy of living things. Their dynamism, along with the complexity of their mechanical response (which in itself involves complex chemical, electrical, and thermal phenomena) makes it very difficult to correlate empirical data with theoretical models. This difficulty elevates the importance of useful biomechanical theories compared to other fields of engineering. Despite inherent imperfections of all theories, a well formulated theory is crucial in any field of science because it is the basis for interpreting observations. This is all-the-more vital, for… More >

V. Sansalone^1,∗, V. Bousson², S. Naili¹, C. Bergot², F. Peyrin³, J.D. Laredo², G. Haïat¹

CMES-Computer Modeling in Engineering & Sciences, Vol.87, No.5, pp. 387-410, 2012, DOI:10.3970/cmes.2012.087.387

Abstract This paper investigates the effects of the heterogeneous distribution of the Haversian Porosity (HP) and Tissue Mineral Density (TMD) on the elastic coefficients of bone in the human femoral neck. A bone specimen from the inferior femoral neck was obtained from a patient undergoing standard hemiarthroplasty. The specimen was imaged using 3-D synchrotron micro-computed tomography (voxel size of 10.13 mm), leading to the determination of the anatomical distributions of HP and TMD. These experimental data were used to estimate the elastic coefficients of the bone using a three-step homogenization model based on continuum micromechanics: (i)… More >

D.D. D’Lima^*, P.C. Chen^†, O. Kessler^‡, H.R. Hoenecke^*, C.W. Colwell Jr.^∗§

Molecular & Cellular Biomechanics, Vol.8, No.2, pp. 123-134, 2011, DOI:10.3970/mcb.2011.008.123

Abstract The menisci are important biomechanical components of the knee. We developed and validated a finite element model of meniscal replacement to assess the effect of surgical fixation technique on contact behavior and knee stability. The geometry of femoral and tibial articular cartilage and menisci was segmented from magnetic resonance images of a normal cadaver knee using MIMICS (Materialise, Leuven, Belgium). A finite element mesh was generated using HyperWorks (Altair Inc, Santa Ana, CA). A finite element solver (Abaqus v6.9, Simulia, Providence, RI) was used to compute contact area and stresses under axial loading and to… More >

I. Pérez¹, R. Roselló¹, C. Recarey¹, M. Cerrolaza²

CMES-Computer Modeling in Engineering & Sciences, Vol.79, No.3&4, pp. 183-200, 2011, DOI:10.3970/cmes.2011.079.183

Abstract Modeling the geometry and behavior of human bones is of the most concern when dealing with bone remodelling (external and internal) and poroelastic analysis. Complex geometries are frequently found in the human skeleton as well as orthotropic behavior of bone tissue. Spongy bone has a completely different constitution as compared with compact bone, which adds another relevant consideration if we want to get reliable results in biomechanical analysis. The modeling of both compact and spongy human-bone tissue is carried out by using packaging-particle methods. The methods generate circles (2D domains) and spheres (3D domains) in More >