G. R. Liu^{1, 2}

The International Conference on Computational & Experimental Engineering and Sciences, Vol.12, No.4, pp. 113-114, 2009, DOI:10.3970/icces.2009.012.113

Abstract This paper introduces first a weakened weakform (W2) using a generalized gradient smoothing technique for an unified formulation of a wide class of compatible and incompatible displacement methods including settings of the finite element methods (FEM) and meshfree methods of special properties including the upper bound properties. A G space is first defined to include discontinuous functions allowing the use of much more types of methods/techniques to create shape functions for numerical models; Properties and a set of important inequalities for G spaces are then proven in theory and analyzed in detail. We prove that the numerical methods developed based… More >

Emil I. Budescu¹, Ioan Iacob²

The International Conference on Computational & Experimental Engineering and Sciences, Vol.8, No.1, pp. 31-40, 2008, DOI:10.3970/icces.2008.008.031

Abstract This article has no abstract. More >

Fernanda Gentil¹, Renato Natal Jorge², António Joaquim Mendes Ferreira³, Marco Parente⁴, Pedro Martins⁵, Eurico de Almeida⁶

The International Conference on Computational & Experimental Engineering and Sciences, Vol.9, No.1, pp. 45-56, 2009, DOI:10.3970/icces.2009.009.045

Abstract The interest in finite element method (FEM) concerning biomechanics has been increasing, in particular, to analyze the mechanical behavior of the human ear. In this work, a finite element model of the middle ear was made. A dynamic study based on a structural response to harmonic vibrations, for different sound pressure levels, applied on the eardrum, is presented using the ABAQUS program. The model includes different ligaments and muscle tendons with elastic and hyperelastic behavior of these supportive structure. The non-linear behavior of the ligaments and muscle tendons was considered, being the connection between ossicles done by contact formulation. Harmonic… More >

Christine M. Scotti¹, Sergio L. Cornejo², Ender A. Finol³

The International Conference on Computational & Experimental Engineering and Sciences, Vol.1, No.1, pp. 41-48, 2007, DOI:10.3970/icces.2007.001.041

Abstract Abdominal aortic aneurysm (AAA) rupture is believed to represent the culmination of a complex vascular mechanism partially driven by the forces exerted on the arterial wall. In the present investigation, we present fully coupled fluid-structure interaction (FSI) and finite element analysis (FEA) computations of a patient-specific AAA model. This work advances previous FSI AAA modeling by including localized intraluminal thrombus and the comparison of FSI- and FEA-predicted wall stress distributions. The FSI transient fluid and wall dynamics resulted in a maximum wall stress 21% higher than that obtained with FEA, demonstrating the importance of modeling blood flow for the assessment… More >

T. Yamaguchi¹, T. Ishikawa², Y. Imai²

The International Conference on Computational & Experimental Engineering and Sciences, Vol.9, No.2, pp. 79-80, 2009, DOI:10.3970/icces.2009.009.079

Abstract Human cardiovascular system is always under the integrated nervous and humoral control of the whole body, i.e. in homeostasis. Multiple feedback mechanisms with mutual interactions among systems, organs, and even tissues provide integrated control of the entire body. These control mechanisms have different spatial coverages, from the micro- to macroscale, and different time constants, from nanoseconds to decades. We think that these variations in spatial as well as temporal scales should be taken into account in discussing phenomena in the cardiovascular system.
In this background,we have been investigatingthe cardiovascular system over micro to macro levels by using conjugated computational mechanics… More >

Sara Salehyar^{1, †}, Nickolas Forsch^1,†,*, Kathleen Gilbert^2,3, Alistair A. Young^3,4, James C. Perry⁵, Sanjeet Hegde⁵, Jeffrey H. Omens^1,6, Andrew D. McCulloch^1,6

Molecular & Cellular Biomechanics, Vol.16, No.3, pp. 179-183, 2019, DOI:10.32604/mcb.2019.07384

Abstract Tetralogy of Fallot (TOF) is the most common form of cyanotic congenital heart disease. Infants diagnosed with TOF require surgical interventions to survive into adulthood. However, as a result of postoperative structural malformations and long-term ventricular remodeling, further interventions are often required later in life. To help identify those at risk of disease progression, serial cardiac magnetic resonance (CMR) imaging is used to monitor these patients. However, most of the detailed information on cardiac shape and biomechanics contained in these large four-dimensional (4D) data sets goes unused in clinical practice for lack of efficient and comprehensive quantitative analysis tools. While… More >

Petit Claudie¹, Guignandon Alain², Avril Stéphane^1,*

Molecular & Cellular Biomechanics, Vol.16, No.2, pp. 87-108, 2019, DOI:10.32604/mcb.2019.06415

Abstract The contractile behavior of smooth muscle cells (SMCs) in the aorta is an important determinant of growth, remodeling, and homeostasis. However, quantitative values of SMC basal tone have never been characterized precisely on individual SMCs. Therefore, to address this lack, we developed an in vitro technique based on Traction Force Microscopy (TFM). Aortic SMCs from a human lineage at low passages (4-7) were cultured 2 days in conditions promoting the development of their contractile apparatus and seeded on hydrogels of varying elastic modulus (1, 4, 12 and 25 kPa) with embedded fluorescent microspheres. After complete adhesion, SMCs were artificially detached… More >

Mingzhi Luo¹, Kai Ni¹, Peili Yu¹, Yang Jin², Lei Liu¹, Jingjing Li¹, Yan Pan¹, Linhong Deng^1,*

Molecular & Cellular Biomechanics, Vol.16, No.2, pp. 141-151, 2019, DOI:10.32604/mcb.2019.06756

Abstract Airway hyperresponsiveness (AHR) is the cardinal character of asthma, which involves the biomechanical properties such as cell stiffness and traction force of airway smooth muscle cells (ASMCs). Therefore, these biomechanical properties comprise logical targets of therapy. β2-adrenergic agonist is currently the mainstream drug to target ASMCs in clinical practice for treating asthma. However, this drug is known for side effects such as desensitization and non-responsiveness in some patients. Therefore, it is desirable to search for new drug agents to be alternative of β2-adrenergic agonist. In this context, sanguinarine, a natural product derived from plants such as bloodroots, that has been… More >

Jiangguo Lin¹, Botao Xiao^1,2, Quhuan Li¹, Ying Fang¹, Jianhua Wu^1,*

Molecular & Cellular Biomechanics, Vol.15, No.1, pp. 37-49, 2018, DOI:10.3970/mcb.2018.015.037

Abstract The protein structure-function paradigm implies that the structure of a protein defines its function. Crystallization techniques such as X-ray, electron microscopy (EM) and nuclear magnetic resonance (NMR) have been applied to resolve the crystal structure of numerous proteins, provided beautiful and informative models of proteins. However, proteins are not intrinsically in static state but in dynamic state, which is lack in crystal models. The protein flexibility, a key mechanical property of proteins, plays important roles in various biological processes, such as ligand-receptor interaction, signaling transduction, substrate recognition and post-translational modifications. Advanced time-resolved crystallography has been developed recent years to visualize… More >

Tushar Kulkarni¹, Dr. Rashmi Uddanwadiker²

Molecular & Cellular Biomechanics, Vol.13, No.2, pp. 87-104, 2016, DOI:10.3970/mcb.2016.013.099

Abstract This paper aims to determine the force required for holding the objects by human hand. A static analysis is performed on mathematical models to obtain holding force considering lower arm as class three lever and by varying the joint angles. Three mathematical models are discussed to quantify the force required to hold any object, for different weight of the object and the joint angles. A noninvasive experimentation using surface electromyogram was performed to determine the forces required by human hand for the same objects used in the mathematical modeling. Twenty-one male subjects participated in this test and were asked to… More >