Sarah A. Twichell¹, Corinna J. Rea¹, Patrice Melvin², Andrew J. Capraro¹, Joshua C. Mandel¹, Michael A. Ferguson¹, Daniel J. Nigrin¹, Kenneth D. Mandl¹, Dionne Graham², Justin P. Zachariah³

Congenital Heart Disease, Vol.12, No.4, pp. 484-490, 2017, DOI:10.1111/chd.12469

Abstract Background: Recognition of high blood pressure (BP) in children is poor, partly due to the need to compute age-sex-height referenced percentiles. This study examined the change in abnormal BP recognition before versus after the introduction of an electronic health record (EHR) app designed to calculate BP percentiles with a training lecture.
Methods and results: Clinical data were extracted on all ambulatory, non-urgent encounters for children 3–18 years old seen in primary care, endocrinology, cardiology, or nephrology clinics at an urban, academic hospital in the year before and the year after app introduction. Outpatients with at least 1… More >

Gaiping Zhao¹, Feiyi Xia¹, Eryun Chen², Xiaoli Yu³, Zhaozhi Yang^3,*

Molecular & Cellular Biomechanics, Vol.14, No.1, pp. 47-57, 2017, DOI:10.3970/mcb.2017.014.049

Abstract Metastatic tumor blood perfusion and interstitial fluid transport based on 3D microvasculature response to inhibitory effect of angiostatin are investigated in this paper. 3D blood flow、interstitial fluid transport and transvascular flow are described by the extended Poiseuille’s, Darcy’s and Starling’s law, respectively. Numerical solutions reveal that angiostatin can promote improved blood perfusion and decrease elevated interstitial fluid pressure within the metastatic tumor microenvironment. Moreover, angiostatin can increase interstitial convection within the tumor and result in more efficient drug delivery and penetration within the metastatic tumor, which suits well with the experimental observations. Together, our results More >

Christopher M. Russell^*, Pranav Sharma^*, Gautum Agarwal, John S. Fisher, George J. Richard, Philippe E. Spiess, Julio M. Pow-Sang, Michael A. Poch, Wade J. Sexton

Canadian Journal of Urology, Vol.23, No.1, pp. 8127-8134, 2016

Abstract Introduction: To evaluate whether varying degrees of seminomatous elements in the primary orchiectomy specimen would be predictive of patient morbidity during post-chemotherapy retroperitoneal lymph node dissection (PC-RPLND) since the desmoplastic reaction with seminoma is associated with increased intraoperative complexity.
Materials and methods: We retrospectively identified 127 patients who underwent PC-RPLND for residual retroperitoneal masses. Clinicodemographic, intraoperative, and 30 day postoperative outcomes were compared for patients with pure seminoma (SEM), mixed germ cell tumors (GCT) containing seminoma elements (NS+SEM), and tumors with no seminoma elements (NS). Multivariate logistic regression was used to determine independent predictors of intraoperative and… More >

Wilson Sui, Ifeanyi C. Onyeji, Justin T. Matulay, Marissa C. Theofanides, Maxwell B. James, G. Joel DeCastro, Sven Wenske

Canadian Journal of Urology, Vol.23, No.4, pp. 8348-8355, 2016

Abstract Introduction: To assess 30-day morbidity and mortality following partial nephrectomy (PN) and radical nephrectomy (RN) with relation to the administration of perioperative blood transfusions (PBT).
Materials and methods: The National Surgical Quality Improvement Program was queried for patients with malignant renal tumors (International Classification of Diseases Ninth Revision codes 189-189.2) who underwent RN (Current Procedure Terminology codes 50220, 50225, 50230, 50234, 50236, 50545, 50546, 50548) or PN (50240, 50543) between 2005-2013. Patients were stratified by transfusion status and assessed for postoperative outcomes both separately and in composite, including morbidity, mortality, infectious complications, and pulmonary complications. Univariate and… More >

Jen-Jane Liu¹, Patrick Mullane², Max Kates³, Nilay Gandhi³, Mark P. Schoenberg⁴, Charles Drake⁵, Noah M. Hahn⁵, Steve Frank⁶, Trinity J. Bivalacqua³

Canadian Journal of Urology, Vol.23, No.4, pp. 8342-8347, 2016

Abstract Introduction: Infectious complications are common after radical cystectomy (RC), and allogeneic blood transfusions may increase infection risk by an immunosuppressive effect. While it has been suggested that perioperative blood transfusion (PBT) may be associated with adverse oncologic outcomes after RC, no large analyses have assessed whether PBT increases the risk of perioperative infection after RC.
Materials and methods: We used the Nationwide Inpatient Sample (1998 to 2011) to study the rate of PBT during RC for bladder cancer and identify infectious complications. We compared rates of infectious complications in patients who did and did not receive PBT… More >

PoojaJhunjhunwala¹, P.M. Padole², S.B. Thombre³

Molecular & Cellular Biomechanics, Vol.13, No.1, pp. 1-21, 2016, DOI:10.3970/mcb.2016.013.001

Abstract This paper presents Computational fluid dynamic (CFD) analysis of blood flow in three different 3-D models of left coronary artery (LCA). A comparative study of flow parameters (pressure distribution, velocity distribution and wall shear stress) in each of the models is done for a non-Newtonian (Carreau) as well as the Newtonian nature of blood viscosity over a complete cardiac cycle. The difference between these two types of behavior of blood is studied for both transient and steady states of flow. Additionally, flow parameters are compared for steady and transient boundary conditions considering blood as non-Newtonian More >

Andrew Cohen¹, Rodrigo Ledezma-Rojas¹, Ernest Mhoon², Gregory Zagaja¹

Canadian Journal of Urology, Vol.22, No.3, pp. 7834-7835, 2015

Abstract Bilateral bloody otorrhea is a rare complication of surgery and to our knowledge a previously unpublished event. We review the case of a 50-year-old male who underwent robotic-assisted laparoscopic radical prostatectomy (RALP) with bilateral lymphadenectomy for Gleason’s Score 4 + 4 = 8 prostate cancer. Bloody discharge from bilateral auditory canals was noted upon removal of the surgical drapes. Otolaryngologic examination revealed bilateral anterior auditory canal hematomas without any loss of hearing. Steep Trendelenburg position in combination with perioperative anticoagulants may have contributed to this complication. Given the rarity of this event no specific risk More >

Jonathan A. Wu¹, Tin C. Ngo¹, Cappy Rothman², Benjamin N. Breyer³, Michael L. Eisenberg¹

Canadian Journal of Urology, Vol.22, No.5, pp. 7973-7977, 2015

Abstract Introduction: To use Google Insights search volume and publicly available economic indicators to test the hypothesis that sperm, egg, and blood donations increase during economic downturns and to demonstrate the feasibility of using Google search volume data to predict national trends in actual sperm, egg, and blood donations rates.
Materials and methods: Cross-correlation statistical analysis comparing Google search data for terms relating to blood, egg, and sperm donations with various economic indicators including the S&P 500 closing values, gross domestic product (GDP), the U.S. Index of Leading Indicators (U.S. Leading Index), gross savings rate, mortgage interest rates,… More >

P. Jhunjhunwala^∗,†, P.M. Padole^∗,‡, S.B. Thombre^∗,§

Molecular & Cellular Biomechanics, Vol.12, No.1, pp. 37-47, 2015, DOI:10.3970/mcb.2015.012.037

Abstract CFD analysis plays an important role in the area of analysis of blood flow as in-vivo measurements of blood flow is costly and easily not accessible. This paper presents simulation of blood flow in healthy and stenosed coronary artery 2- D models. The simulation was done considering non-Newtonian behavior of blood and pulsatile nature of blood flow which is close to physical scenario. Pressure distribution, velocity distribution and wall shear were examined to understand their effect on Atherosclerosis. More >

Chetan Kuthe^∗, R. V. Uddanwadiker^†, P. M. Padole^‡, A. A. Ramteke^§

Molecular & Cellular Biomechanics, Vol.12, No.1, pp. 1-16, 2015, DOI:10.3970/mcb.2015.012.001

Abstract Skeletal muscles are responsible for the relative motion of the bones at the joints and provide the required strength. They exhibit highly nonlinear mechanical behaviour and are described by nonlinear hyperelastic constitutive relations. It is distinct from other biological soft tissue. Its hyperelastic or viscoelastic behaviour is modelled by using CE, SEE, and PEE. Contractile element simulates the behaviour of skeletal muscle when it is subjected to eccentric and concentric contraction. This research aims to estimate the stress induced in skeletal muscle in eccentric and concentric contraction with respect to the predefined strain. With the… More >