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Search Results (734)
  • Open Access

    REVIEW

    Clinical implications of single cell sequencing for bladder cancer

    REZA YADOLLAHVANDMIANDOAB1,#, MEHRSA JALALIZADEH1,#, FRANCIELE APARECIDA VECHIA DIONATO1, KEINI BUOSI1, PATRÍCIA A. F. LEME1, LUCIANA S. B. DAL COL1, CRISTIANE F. GIACOMELLI1, ALEX DIAS ASSIS1, NASIM BASHIRICHELKASARI1, LEONARDO OLIVEIRA REIS1,2,*

    Oncology Research, Vol.32, No.4, pp. 597-605, 2024, DOI:10.32604/or.2024.045442

    Abstract Bladder cancer (BC) is the 10th most common cancer worldwide, with about 0.5 million reported new cases and about 0.2 million deaths per year. In this scoping review, we summarize the current evidence regarding the clinical implications of single-cell sequencing for bladder cancer based on PRISMA guidelines. We searched PubMed, CENTRAL, Embase, and supplemented with manual searches through the Scopus, and Web of Science for published studies until February 2023. We included original studies that used at least one single-cell technology to study bladder cancer. Forty-one publications were included in the review. Twenty-nine studies showed that this technology can identify… More > Graphic Abstract

    Clinical implications of single cell sequencing for bladder cancer

  • Open Access

    ARTICLE

    Dual ligand-targeted Pluronic P123 polymeric micelles enhance the therapeutic effect of breast cancer with bone metastases

    HUAN GAO1,2, JIE ZHANG1, TONY G. KLEIJN1,3,4, ZHAOYONG WU5, BING LIU1,6, YUJIN MA6, BAOYUE DING1,*, DONGFENG YIN2,*

    Oncology Research, Vol.32, No.4, pp. 769-784, 2024, DOI:10.32604/or.2023.044276

    Abstract Bone metastasis secondary to breast cancer negatively impacts patient quality of life and survival. The treatment of bone metastases is challenging since many anticancer drugs are not effectively delivered to the bone to exert a therapeutic effect. To improve the treatment efficacy, we developed Pluronic P123 (P123)-based polymeric micelles dually decorated with alendronate (ALN) and cancer-specific phage protein DMPGTVLP (DP-8) for targeted drug delivery to breast cancer bone metastases. Doxorubicin (DOX) was selected as the anticancer drug and was encapsulated into the hydrophobic core of the micelles with a high drug loading capacity (3.44%). The DOX-loaded polymeric micelles were spherical,… More > Graphic Abstract

    Dual ligand-targeted Pluronic P123 polymeric micelles enhance the therapeutic effect of breast cancer with bone metastases

  • Open Access

    ARTICLE

    Neural Wiskott-Aldrich syndrome protein (N-WASP) promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2

    HYUNG SUN KIM1,#, YUN SUN LEE2,#, SEUNG MYUNG DONG3, HYO JUNG KIM1, DA EUN LEE2, HYEON WOONG KANG2, MYEONG JIN KIM2, JOON SEONG PARK1,*

    Oncology Research, Vol.32, No.4, pp. 615-624, 2024, DOI:10.32604/or.2024.044029

    Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive solid malignancies. A specific mechanism of its metastasis has not been established. In this study, we investigated whether Neural Wiskott-Aldrich syndrome protein (N-WASP) plays a role in distant metastasis of PDAC. We found that N-WASP is markedly expressed in clinical patients with PDAC. Clinical analysis showed a notably more distant metastatic pattern in the N-WASP-high group compared to the N-WASP-low group. N-WASP was noted to be a novel mediator of epithelial-mesenchymal transition (EMT) via gene expression profile studies. Knockdown of N-WASP in pancreatic cancer cells significantly inhibited cell invasion, migration,… More > Graphic Abstract

    Neural Wiskott-Aldrich syndrome protein (N-WASP) promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2

  • Open Access

    ARTICLE

    Investigation of the feasibility of NRAV as a biomarker for hepatocellular carcinoma

    JUN LIU1,2,3,#, WENLI LI3, RUYUE LU1,2, JIAQING XU1,2, CHUNHUI JIANG4, JUNLIN DUAN3, LINGZHI ZHANG1,#,*, GUANFU WANG1, JIAXI CHEN1,2,#,*

    Oncology Research, Vol.32, No.4, pp. 717-726, 2024, DOI:10.32604/or.2023.043575

    Abstract The long non-coding RNA, Negative Regulator of Antiviral Response (NRAV) has been identified as a participant in both respiratory virus replication and immune checkpoints, however, its involvement in pan-cancer immune regulation and prognosis, particularly those of hepatocellular carcinoma (HCC), remains unclear. To address this knowledge gap, we analyzed expression profiles obtained from The Cancer Genome Atlas (TCGA) database, comparing normal and malignant tumor tissues. We found that NRAV expression is significantly upregulated in tumor tissues compared to adjacent nontumor tissues. Kaplan-Meier (K-M) analysis revealed the prognostic power of NRAV, wherein overexpression was significantly linked to reduced overall survival in a… More >

  • Open Access

    ARTICLE

    Developing risk models and subtypes of autophagy-associated LncRNAs for enhanced prognostic prediction and precision in therapeutic approaches for liver cancer patients

    LU ZHANG*, JINGUO CHU*, YUSHAN YU

    Oncology Research, Vol.32, No.4, pp. 703-716, 2024, DOI:10.32604/or.2023.030988

    Abstract Background: Limited research has been conducted on the influence of autophagy-associated long non-coding RNAs (ARLncRNAs) on the prognosis of hepatocellular carcinoma (HCC). Methods: We analyzed 371 HCC samples from TCGA, identifying expression networks of ARLncRNAs using autophagy-related genes. Screening for prognostically relevant ARLncRNAs involved univariate Cox regression, Lasso regression, and multivariate Cox regression. A Nomogram was further employed to assess the reliability of Riskscore, calculated from the signatures of screened ARLncRNAs, in predicting outcomes. Additionally, we compared drug sensitivities in patient groups with differing risk levels and investigated potential biological pathways through enrichment analysis, using consensus clustering to identify subgroups… More >

  • Open Access

    REVIEW

    Exploring the molecular mechanisms and potential therapeutic strategies of ferroptosis in ovarian cancer

    LISHA MA1,#, WANQI SHAO1,#, WEILI ZHU2,*

    BIOCELL, Vol.48, No.3, pp. 379-386, 2024, DOI:10.32604/biocell.2024.047812

    Abstract The morbidity rate of ovarian cancer, a malignant tumour in gynaecological tumours, is rising, and it is considered to be the most lethal cancer. The majority of patients are typically diagnosed during the advanced stages of the illness due to the elusive characteristics of ovarian cancer and an absence of highly sensitive and specific diagnostic indicators. Surgical excision of the lesions, along with chemotherapy, is the conventional treatment for ovarian cancer; however, resistance to platinum-based chemotherapeutic drugs and molecular targeted therapies frequently arises. Improving the survival rate and prognosis of patients with end-stage or recurring ovarian cancer requires the identification… More >

  • Open Access

    ARTICLE

    Analysis of large datasets for identifying molecular targets in intestinal polyps and metabolic disorders

    SHAN OU#, YUN XU#, QINGLAN LIU, TIANWEN YANG, WEI CHEN, XIU YUAN, XIN ZUO, PENG SHI*, JIE YAO*

    BIOCELL, Vol.48, No.3, pp. 415-429, 2024, DOI:10.32604/biocell.2024.046178

    Abstract Background: The interrelation between intestinal polyps, metabolic syndrome (MetS), and colorectal cancer (CRC) is a critical area of study. This research focuses on pinpointing potential molecular targets to understand the link between intestinal polyp formation, metabolic irregularities, and CRC progression. Methods: We examined clinical samples from patients with intestinal polyps coexisting with MetS and compared them with samples from patients with standard intestinal polyps. Transcriptome sequencing and public database analysis were employed to identify significant pathways and genes. These targets were then validated through immunohistochemistry (IHC). Following the RNA interference of key target expression, a series of experiments, including the… More > Graphic Abstract

    Analysis of large datasets for identifying molecular targets in intestinal polyps and metabolic disorders

  • Open Access

    REVIEW

    MicroRNAs modulation in lung cancer: exploring dual mechanisms and clinical prospects

    SHAHID HUSSAIN1,*, HABIB BOKHARI1, XINGXING FAN2, SHAUKAT IQBAL MALIK3, SUNDAS IJAZ1, MUHAMMAD ADNAN SHEREEN4, AIMAN FATIMA3

    BIOCELL, Vol.48, No.3, pp. 403-413, 2024, DOI:10.32604/biocell.2024.044801

    Abstract The global incidence of lung cancer is marked by a considerably elevated mortality rate. MicroRNAs (miRNAs) exert pivotal influence in the intricate orchestration of gene regulation, and their dysregulation can precipitate dire consequences, notably cancer. Within this context, miRNAs encapsulated in exosomes manifest a diversified impact on the landscape of lung cancer, wherein their actions may either foster angiogenesis, cell proliferation, and metastasis, or counteract these processes. This comprehensive review article discerns potential targets for the prospective development of therapeutic agents tailored for lung cancer. Tumor-suppressive miRNAs, such as miR-204, miR-192, miR-30a, miR-34a, miR-34b, miR-203, and miR-212, exhibit heightened expression… More >

  • Open Access

    ARTICLE

    Curcumin inhibits colorectal cancer development by blocking the YAP/TAZ signaling axis

    FEI SHA1, DAISHAN XIN2, JUN XU3, ZHIWEI ZHENG1, WENXIN LIN1, XIAORUI CAI1, FEI LIN3, MINGHAO ZHENG1,*, JIAOLING CHEN1,*

    BIOCELL, Vol.48, No.3, pp. 443-451, 2024, DOI:10.32604/biocell.2023.029188

    Abstract Background: Curcumin is a plant polyphenol with antitumor properties and inhibits the development of colorectal cancer (CRC). However, as the molecular mechanism associated is still unclear, our study aimed to explore the underlying molecular mechanisms by which curcumin inhibits CRC. Methods: HT29 and SW480 cells were treated with curcumin or/and Doxycycline (DOX), and cell viability, colony forming ability, migration and invasion were confirmed by cell counting kit-8 (CCK-8), colony forming, Transwell assays. And Yes-associated protein 1 (YAP) and PDZ-binding motif (TAZ) signaling-related genes or proteins were analyzed using reverse transcription quantitative real-time PCR (RT-qPCR), western blot, and immunofluorescence assays. Then… More > Graphic Abstract

    Curcumin inhibits colorectal cancer development by blocking the YAP/TAZ signaling axis

  • Open Access

    ARTICLE

    Multilevel Attention Unet Segmentation Algorithm for Lung Cancer Based on CT Images

    Huan Wang1, Shi Qiu1,2,*, Benyue Zhang1, Lixuan Xiao3

    CMC-Computers, Materials & Continua, Vol.78, No.2, pp. 1569-1589, 2024, DOI:10.32604/cmc.2023.046821

    Abstract Lung cancer is a malady of the lungs that gravely jeopardizes human health. Therefore, early detection and treatment are paramount for the preservation of human life. Lung computed tomography (CT) image sequences can explicitly delineate the pathological condition of the lungs. To meet the imperative for accurate diagnosis by physicians, expeditious segmentation of the region harboring lung cancer is of utmost significance. We utilize computer-aided methods to emulate the diagnostic process in which physicians concentrate on lung cancer in a sequential manner, erect an interpretable model, and attain segmentation of lung cancer. The specific advancements can be encapsulated as follows:… More >

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