JINXIA CHEN^1,2,3,#, SULI DAI^1,2,#, GENG ZHANG^4,5, SISI WEI^1,2, XUETAO ZHAO³, YANG ZHENG^1,2, YAOJIE WANG^1,2, XIAOHAN WANG^1,2, YUNJIANG LIU^4,5,*, LIANMEI ZHAO^1,2,*

Oncology Research, Vol.32, No.11, pp. 1791-1802, 2024, DOI:10.32604/or.2024.049348 - 16 October 2024

Abstract Background: Triple-negative breast cancer (TNBC) is a heterogeneous, recurring cancer characterized by a high rate of metastasis, poor prognosis, and lack of efficient therapies. KBU2046, a small molecule inhibitor, can inhibit cell motility in malignant tumors, including breast cancer. However, the specific targets and the corresponding mechanism of its function remain unclear. Methods: In this study, we employed (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H tetrazolium) (MTS) assay and transwell assay to investigate the impact of KBU2046 on the proliferation and migration of TNBC cells in vitro. RNA-Seq was used to explore the targets of KBU2046 that inhibit the motility of TNBC.… More > Graphic Abstract

YONGJIAN HUANG, JINZHOU WANG, JIUHUA XU, NING RUAN^*

Oncology Research, Vol.32, No.11, pp. 1765-1776, 2024, DOI:10.32604/or.2024.045564 - 16 October 2024

Abstract Background: Despite significant advancements in the development of anticancer therapies over the past few decades, the clinical management of colorectal cancer remains a challenging task. This study aims to investigate the inhibitory effects of cancer-targeting liposomes against colorectal cancer. Materials and Methods: Liposomes consisting of 3β-[N-(N′, N′-dimethylamino ethane)carbamoyl]-cholesterol (DC-CHOL), cholesterol (CHOL), and dioleoylphosphatidylethanolamine (DOPE) at a molar ratio of 1:1:0.5 were created and used as carriers to deliver an apoptosis-inducing plasmid encoding the tumor necrosis factor-related apoptosis-inducing ligand (pTRAIL) gene, along with the toll-like receptor (TLR7) agonist Rsiquimod (R848). The rationale behind this design is that More > Graphic Abstract

YE ZHANG¹, YANAN LIANG², YAN WU², LIWEN SONG², ZUWANG ZHANG^2,*

Oncology Research, Vol.32, No.11, pp. 1747-1763, 2024, DOI:10.32604/or.2024.030945 - 16 October 2024

Abstract Background: Papillary thyroid cancer (PTC) is the most prevalent histological type of differentiated thyroid malignancy. Circular RNAs (circRNAs) have been implicated in the pathogenesis and progression of various cancers. circTIAM1 (hsa_circ_0061406) is a novel circRNA with aberrant expression in PTC. However, its functional roles in PTC progression remain to be investigated. Methods: The expression levels of circTIAM1 in the PTC and the matched para-cancerous tissues were detected by quantitative real-time reverse-transcription PCR (qRT-PCR). The subcellular localization of circTIAM1 was examined by fluorescence in-situ hybridization (FISH). Kaplan-Meier plot was used to analyze the association of clinicopathological features… More >

Rabia Javed¹, Tanzila Saba², Tahani Jaser Alahmadi^3,*, Sarah Al-Otaibi⁴, Bayan AlGhofaily², Amjad Rehman²

CMC-Computers, Materials & Continua, Vol.81, No.1, pp. 809-825, 2024, DOI:10.32604/cmc.2024.052755 - 15 October 2024

Abstract Cancer poses a significant threat due to its aggressive nature, potential for widespread metastasis, and inherent heterogeneity, which often leads to resistance to chemotherapy. Lung cancer ranks among the most prevalent forms of cancer worldwide, affecting individuals of all genders. Timely and accurate lung cancer detection is critical for improving cancer patients’ treatment outcomes and survival rates. Screening examinations for lung cancer detection, however, frequently fall short of detecting small polyps and cancers. To address these limitations, computer-aided techniques for lung cancer detection prove to be invaluable resources for both healthcare practitioners and patients alike.… More >

Nahed Tawfik^1,*, Heba M. Emara², Walid El-Shafai³, Naglaa F. Soliman⁴, Abeer D. Algarni⁴, Fathi E. Abd El-Samie⁴

CMC-Computers, Materials & Continua, Vol.81, No.1, pp. 271-307, 2024, DOI:10.32604/cmc.2024.052404 - 15 October 2024

Abstract Lung cancer remains a major concern in modern oncology due to its high mortality rates and multifaceted origins, including hereditary factors and various clinical changes. It stands as the deadliest type of cancer and a significant cause of cancer-related deaths globally. Early diagnosis enables healthcare providers to administer appropriate treatment measures promptly and accurately, leading to improved prognosis and higher survival rates. The significant increase in both the incidence and mortality rates of lung cancer, particularly its ranking as the second most prevalent cancer among women worldwide, underscores the need for comprehensive research into efficient… More >

Feyza Altunbey Özbay¹, Erdal Özbay², Farhad Soleimanian Gharehchopogh^3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.141, No.2, pp. 1067-1110, 2024, DOI:10.32604/cmes.2024.054334 - 27 September 2024

Abstract Artificial rabbits optimization (ARO) is a recently proposed biology-based optimization algorithm inspired by the detour foraging and random hiding behavior of rabbits in nature. However, for solving optimization problems, the ARO algorithm shows slow convergence speed and can fall into local minima. To overcome these drawbacks, this paper proposes chaotic opposition-based learning ARO (COARO), an improved version of the ARO algorithm that incorporates opposition-based learning (OBL) and chaotic local search (CLS) techniques. By adding OBL to ARO, the convergence speed of the algorithm increases and it explores the search space better. Chaotic maps in CLS… More > Graphic Abstract

Daasara Keshavamurthy Archana¹, Doddabhadrappla Gowda Prakasha¹, Pundikala Veeresha², Kottakkaran Sooppy Nisar^3,4,*

CMES-Computer Modeling in Engineering & Sciences, Vol.141, No.2, pp. 1347-1363, 2024, DOI:10.32604/cmes.2024.053916 - 27 September 2024

Abstract This study intends to examine the analytical solutions to the resulting one-dimensional differential equation of a cancer tumor model in the frame of time-fractional order with the Caputo-fractional operator employing a highly efficient methodology called the -homotopy analysis transform method. So, the preferred approach effectively found the analytic series solution of the proposed model. The procured outcomes of the present framework demonstrated that this method is authentic for obtaining solutions to a time-fractional-order cancer model. The results achieved graphically specify that the concerned paradigm is dependent on arbitrary order and parameters and also disclose the More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.10, pp. 1697-1698, 2024, DOI:10.32604/or.2024.056918 - 18 September 2024

Abstract This article has no abstract. More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.10, pp. 1693-1694, 2024, DOI:10.32604/or.2024.056909 - 18 September 2024

Abstract This article has no abstract. More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.10, pp. 1689-1690, 2024, DOI:10.32604/or.2024.056905 - 18 September 2024

Abstract This article has no abstract. More >