Jian-Guo Wen

Canadian Journal of Urology, Vol.32, No.5, pp. 367-368, 2025, DOI:10.32604/cju.2025.073520 - 30 October 2025

Abstract This article has no abstract. More >

LIBO LIANG¹, XINYI WANG^2,3,4, YUPING ZENG^2,3,4, HAO CHEN^2,3,4, WEN ZHOU¹, HONGYING MU^2,3,4, GA LIAO^5,6,*

Oncology Research, Vol.33, No.6, pp. 1405-1421, 2025, DOI:10.32604/or.2024.056708 - 29 May 2025

Abstract Objectives: Exosomal long noncoding RNAs (lncRNAs) might facilitate epithelial–mesenchymal transition (EMT) in liver cancer after transarterial chemoembolization (TACE), thereby enhancing tumor cell invasiveness and migration. This study investigated the prognostic role of plasma exosomal long noncoding RNA-plasmacytoma variant translocation 1 (lncRNA-PVT1) in TACE treated hepatocellular carcinoma (HCC). Methods: Plasma exosomal lncRNA-PVT1 was evaluated via qPCR before and after TACE. Hepatoma cell behavior was investigated in different HCC cell lines. A lncRNA-PVT1 plasmid was synthesized and overexpressed, and si-lncRNA PVT1 was transfected into poorly invasive cells to reveal its influence on cell characteristics. The lncRNA-PVT1–FoxM1 interaction… More > Graphic Abstract

Baker M. Ayyash¹, Yen Chuan Chen², Ahmad Sallehuddin², Ziyad M. Hijazi^1,*

Congenital Heart Disease, Vol.20, No.2, pp. 143-179, 2025, DOI:10.32604/chd.2025.064599 - 30 April 2025

Abstract Pediatric heart valve replacement (PHVR) remains a challenging procedure due to the unique anatomical and physiological characteristics of children, including growth and development, as well as the long-term need for durable valve function. This review provides an overview of both surgical and transcatheter options for aortic, mitral, pulmonary, and tricuspid valve replacements in pediatric patients, highlighting the indications, outcomes, and advancements in technology and technique. Surgical valve replacement traditionally involves the implantation of biological or mechanical prosthetic valves, with biological valves being preferred in children to reduce the need for lifelong anticoagulation therapy. However, the… More >

Dina Anggraini¹, Kurnia Wahyudi², Melawati Hasan³, Sri Endah Rahayuningsih^4,*, Charlotte Johanna Cool³

Congenital Heart Disease, Vol.20, No.2, pp. 133-141, 2025, DOI:10.32604/chd.2025.064164 - 30 April 2025

Abstract Background: Congenital heart disease (CHD) occurs in 9 out of 100 births and is the leading cause of birth defects, with acyanotic CHD being more common. The incidence of adult CHD is rising faster than pediatric CHD. Pulmonary hypertension is the most common complication in untreated CHD patients. Methods: This study is retrospective descriptive research based on medical record data and the results of right heart catheterization examinations in adult acyanotic CHD aged ≥18 years and free from other organ disorders. Results: A total of 103 patients met the inclusion criteria, the majority were young… More >

Yaqi Tang^1,#, Gang Luo^1,#, Huashu Liu², Hao Wan¹, Silin Pan^1,*

Congenital Heart Disease, Vol.20, No.2, pp. 195-200, 2025, DOI:10.32604/chd.2025.063682 - 30 April 2025

Abstract Congenital atrial septal defect (ASD) with severe scoliosis is a rare compound malformation in children. Severe scoliosis should be corrected as soon as possible. The growth rod is suitable for patients with early scoliosis and obvious scoliosis under 10 years old. However, the fluoroscopic radiopaque of titanium alloy plate will inevitably partly make the operative field of interventional occlusion blind. We present a 7-year-old Chinese girl with ASD and scoliosis who underwent spinal correction with a dual-growth rod. In this case, we performed transcatheter closure of ASD solely under the guidance of transthoracic echocardiography. Transthoracic More >

Su Ye¹, Luxi Guan¹, Dong Luo¹, Fengwen Zhang¹, Jianhua Lv¹, Qizong Xie², Qiao Huang², Haiming Wu², Haibo Hu^1,*, Xiangbing Pan^1,*

Congenital Heart Disease, Vol.20, No.2, pp. 181-193, 2025, DOI:10.32604/chd.2025.063297 - 30 April 2025

Abstract Objectives: This study aimed to evaluate the feasibility, safety, and efficacy of a novel transcatheter suture closure system (HaloStitch^®) for patent foramen ovale (PFO) closure in a swine model. Methods: Thirteen swine underwent experimental PFO model creation. All animals received implantation of the transcatheter suture closure system to evaluate procedural success. Comprehensive follow-up over six months included serial ultrasound imaging, histopathological analysis, and gross anatomical examination of cardiac specimens. Results: Successful HaloStitch^® device implantation was achieved in 11 of 13 swine. Gross anatomical examination confirmed secure positioning of all sutures in the atrial septum, with no redundancy or… More >

Wyatt MacNevin^1,*, Daniel T. Keefe^1,2, Karen Milford^1,2, Nicholas R. Paterson¹

Canadian Journal of Urology, Vol.32, No.1, pp. 5-13, 2025, DOI:10.32604/cju.2025.064697 - 20 March 2025

Abstract Urethral catheterization is an important skill to develop as consultations for “difficult catheterization” are common in practice. Developing a broad approach to difficult urethral catheterization is crucial to improve trainee success rates. Strategies and techniques to improve catheterization success are often passed down and shared between trainees without formal documentation or dissemination of techniques. Herein, we present a framework for difficult urethral catheterization based on clinical history and patient examination, while also providing additional techniques and troubleshooting to overcome common challenges with urethral catheterization in adult and pediatric patients. More >

Aalya Hamouda¹, Ahmed Ibrahim², Nicholas Corsi³, Giampaolo Siena⁴,Dean S. Elterman⁵, Bilal Chughtai⁶, Naeem Bhojani², Francesco Sessa⁴, Anna Rivetti⁴, Silvia Secco⁷, Kevin C. Zorn^2,8

Canadian Journal of Urology, Vol.31, No.1, pp. 11802-11808, 2024

Abstract Minimally invasive surgery techniques (MIST) have become newly adopted in urological care. Given this, new analgesic techniques are important in optimizing patient outcomes and resource management. Rez ūm treatment (RT) for BPH has emerged as a new MIST with excellent patient outcomes, including improving quality of life (QoL) and International Prostate Symptom Scores (IPSSs), while also preserving sexual function. Currently, the standard analgesic approach for RT involves a peri prostatic nerve block (PNB) using a transrectal ultrasound (TRUS) or systemic sedation anesthesia. The TRUS approach is invasive, uncomfortable, and holds a risk of infection. Additionally,… More >

Hanfang Deng^1,2, Zhimin Yang¹, Wenlan Zhang³, Zhuomin Xu¹, Lin Chen¹, Yueyue Zhang¹, Li Yuan^1,*, Wenyi Luo^4,*

Congenital Heart Disease, Vol.19, No.6, pp. 603-615, 2024, DOI:10.32604/chd.2025.057681 - 27 January 2025

Abstract Objective: To investigate the status and influencing factors of central venous catheter-associated thrombosis in children after congenital heart surgery and to provide evidence for preventive measures. Methods: From January 2024 to March 2024, hospitalized children with central venous catheters (CVC) in the Shanghai Grade III Children’s Hospital intensive care unit were selected. Catheter-related thrombosis (CRT) was evaluated using bedside ultrasound technology combined with visible thrombus after CVC extraction, dividing the patients into the thrombus and non-thrombus groups. Univariate and LASSO regression analyses were used to analyze the factors influencing CRT in children after congenital heart More >

Biagio Castaldi^1,*, Francesco Prati¹, Alice Pozza^1,2, Irene Cattapan^1,2, Jennifer Fumanelli^1,2, Domenico Sirico¹, Giovanni Di Salvo¹

Congenital Heart Disease, Vol.19, No.5, pp. 513-533, 2024, DOI:10.32604/chd.2025.058053 - 31 December 2024

Abstract Congenital heart disease (CHD) affects about 1% of live births. Among them, about 20% will undergo one or more surgical or percutaneous maneuvers on the right ventricle outflow tract or pulmonary valve. Transcatheter pulmonary valve implantation is a recently available less invasive alternative to surgery for treatment of right ventricular outflow tract dysfunction. Thus, residual dysfunction can be treated early and with a lower risk profile. This narrative review aimed to describe the state of the art of percutaneous pulmonary valve implantation. More >