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  • Open Access

    ARTICLE

    DNA Methylation Variation Is Identified in Monozygotic Twins Discordant for Congenital Heart Diseases

    Shuliang Xia1,2,3,#, Huikang Tao2,#, Shixin Su4, Xinxin Chen2, Li Ma2, Jianru Li5, Bei Gao6, Xumei Liu5, Lei Pi7, Jinqing Feng4, Fengxiang Li2, Jia Li4,*, Zhiwei Zhang1,3,*

    Congenital Heart Disease, Vol.19, No.2, pp. 247-256, 2024, DOI:10.32604/chd.2024.052583

    Abstract Aims: Multiple genes and environmental factors are known to be involved in congenital heart disease (CHD), but epigenetic variation has received little attention. Monozygotic (MZ) twins with CHD provide a unique model for exploring this phenomenon. In order to investigate the potential role of Deoxyribonucleic Acid (DNA) methylation in CHD pathogenesis, the present study examined DNA methylation variation in MZ twins discordant for CHD, especially ventricular septal defect (VSD). Methods and Results: Using genome-wide DNA methylation profiles, we identified 4004 differentially methylated regions (DMRs) in 18 MZ twin pairs discordant for CHD, and 2826 genes were identified. Gene Ontology (GO)… More > Graphic Abstract

    DNA Methylation Variation Is Identified in Monozygotic Twins Discordant for Congenital Heart Diseases

  • Open Access

    CASE REPORT

    Bicuspidization Using the Open-Sleeve Technique for Congenital Aortic Stenosis during Infancy

    Toshi Maeda*, Hiroki Ito, Keiichi Hirose, Kisaburo Sakamoto

    Congenital Heart Disease, Vol.19, No.2, pp. 177-183, 2024, DOI:10.32604/chd.2024.050945

    Abstract Congenital aortic stenosis (cAS) frequently requires intervention during the neonatal or infantile period. However, surgical repair is challenging because of the narrow surgical space. We performed bicuspidization using the open-sleeve technique for cAS with a unicuspid aortic valve in two patients. Postoperatively, the patients were doing well without reintervention for the aortic valve for 8 and 6 years, respectively. Their aortic annular diameter increased along with somatic growth. Bicuspidization for neonates or infancy can be performed safely using the open-sleeve technique as its midterm results have been satisfactory. More > Graphic Abstract

    Bicuspidization Using the Open-Sleeve Technique for Congenital Aortic Stenosis during Infancy

  • Open Access

    EDITORIAL

    Health Systems Strengthening to Tackle the Global Burden of Pediatric and Congenital Heart Disease: A Diagonal Approach

    Dominique Vervoort1,2,3,*, Amy Verstappen3, Sreehari Madhavankutty Nair4, Chong Chin Eu5, Bistra Zheleva3,6

    Congenital Heart Disease, Vol.19, No.2, pp. 131-138, 2024, DOI:10.32604/chd.2024.049814

    Abstract This article has no abstract. More >

  • Open Access

    CASE REPORT

    Stubborn Hypoxia in Neonates with D-Transposition of the Great Arteries after Arterial Switch Operation: Central Sleep Apnea as the Cause and Potential Indicator of Brain Immaturity

    Camden L. Hebson1,*, Kyle Bliton2, Amr Y. Hammouda1, Kaitlyn Barr3, W. Hampton Gray4, Mohini Gunnett2, Waldemar F. Carlo1

    Congenital Heart Disease, Vol.19, No.2, pp. 185-195, 2024, DOI:10.32604/chd.2024.048871

    Abstract D-transposition of the great arteries (d-TGA) is surgically repaired with the arterial switch operation (ASO) with excellent results, however short and long-term morbidities still develop including neurocognitive delay. Clinically significant central sleep apnea is uncommon in non-premature infants, but when present indicates immature autonomic control of respiration likely due to a neurologic disorder. We report the unanticipated finding of central sleep apnea in four-term neonates with d-TGA after uncomplicated ASO, with the short-term complication of delayed hospital discharge and long-term concerns regarding this early marker of brain immaturity and its hindrance to normal development. Within this report, we will review… More >

  • Open Access

    REVIEW

    Machine Learning-Based Intelligent Auscultation Techniques in Congenital Heart Disease: Application and Development

    Yang Wang#, Xun Yang#, Mingtang Ye, Yuhang Zhao, Runsen Chen, Min Da, Zhiqi Wang, Xuming Mo, Jirong Qi*

    Congenital Heart Disease, Vol.19, No.2, pp. 219-231, 2024, DOI:10.32604/chd.2024.048314

    Abstract Congenital heart disease (CHD), the most prevalent congenital ailment, has seen advancements in the “dual indicator” screening program. This facilitates the early-stage diagnosis and treatment of children with CHD, subsequently enhancing their survival rates. While cardiac auscultation offers an objective reflection of cardiac abnormalities and function, its evaluation is significantly influenced by personal experience and external factors, rendering it susceptible to misdiagnosis and omission. In recent years, continuous progress in artificial intelligence (AI) has enabled the digital acquisition, storage, and analysis of heart sound signals, paving the way for intelligent CHD auscultation-assisted diagnostic technology. Although there has been a surge… More > Graphic Abstract

    Machine Learning-Based Intelligent Auscultation Techniques in Congenital Heart Disease: Application and Development

  • Open Access

    ARTICLE

    Failure to Rescue as a Quality Metric in Congenital Heart Surgeries in a High-Complexity Service Provider Institution Located in a Middle-Income Country

    Gustavo Cruz1,*, Santiago Pedroza2, Juan F. Vélez3, Jessica Largo2, Juan F. Tejada4, Jorge H. Mejía-Mantilla5

    Congenital Heart Disease, Vol.19, No.2, pp. 207-218, 2024, DOI:10.32604/chd.2024.044244

    Abstract Background: Failure to rescue has been an effective quality metric in congenital heart surgery. Conversely, morbidity and mortality depend greatly on non-modifiable individual factors and have a weak correlation with better-quality performance. We aim to measure the complications, mortality, and risk factors in pediatric patients undergoing congenital heart surgery in a high-complexity institution located in a middle-income country and compare it with other institutions that have conducted a similar study. Methods: A retrospective observational study was conducted in a high-complexity service provider institution, in Cali, Colombia. All pediatric patients undergoing any congenital heart surgery between 2019 and 2022 were included.… More >

  • Open Access

    ARTICLE

    Impact of Atrial Septal Defect Closure on Mortality in Older Patients

    Sipawath Khamplod1,2, Yodying Kaolawanich1,2, Khemajira Karaketklang3, Nithima Ratanasit1,2,*

    Congenital Heart Disease, Vol.19, No.1, pp. 93-105, 2024, DOI:10.32604/chd.2024.048631

    Abstract Background: Atrial septal defect (ASD) is a common form of adult congenital heart disease that can lead to long-term adverse outcomes if left untreated. Early closure of ASD has been associated with excellent outcomes and lower complication rates. However, there is limited evidence regarding the prognosis of ASD closure in older adults. This study aims to evaluate the mortality rates in older ASD patients with and without closure. Methods: A retrospective cohort study was conducted on patients aged 40 years or older with ASD between 2001 and 2017. Patients were followed up to assess all-cause mortality. Univariable and multivariable analyses… More > Graphic Abstract

    Impact of Atrial Septal Defect Closure on Mortality in Older Patients

  • Open Access

    CASE REPORT

    Prenatal Diagnosis of an Apically Located Congenital Left Ventricular Aneurysm: A Rare Case

    Yücel Kaya1,*, And Yavuz1, Hasan Berkan Sayal1, Büşra Tsakir1, Gökalp Kabacaoğlu1, Kadriye Nilay Özcan2

    Congenital Heart Disease, Vol.19, No.1, pp. 123-129, 2024, DOI:10.32604/chd.2024.048145

    Abstract Congenital ventricular aneurysm is a very rare cardiac anomaly. A diagnosis can be made during the prenatal period using fetal echocardiography. This study presents a very rare apically located left ventricular aneurysm case, and the relevant literature was reviewed and discussed. In this case, a 35-year-old, gravida 2, parity 1 pregnant woman at 24 weeks of gestation, displayed a wide aneurysmal image in the left ventricular apical wall on fetal echocardiography. There was a 1.79 mm muscular ventricular septal defect at the apical region of the interventricular septum. In the course of the color Doppler ultrasonography examination, an aberrant fibrous… More >

  • Open Access

    EDITORIAL

    Femoral Access with Ultrasound-Guided Puncture and Z-Stitch Hemostasis for Adults with Congenital Heart Diseases Undergoing Electrophysiological Procedures

    Fu Guan1,*, Matthias Gass2, Florian Berger2, Heiko Schneider1, Firat Duru1,3, Thomas Wolber1,3,*

    Congenital Heart Disease, Vol.19, No.1, pp. 85-92, 2024, DOI:10.32604/chd.2024.047266

    Abstract Aims: Although the application of ultrasound-guided vascular puncture and Z-stitch hemostasis to manage femoral access has been widely utilized, there is limited data on this combined application in adult congenital heart disease (ACHD) patients undergoing electrophysiological (EP) procedures. We sought to evaluate the safety and efficacy of ultrasound-guided puncture and postprocedural Z-stitch hemostasis for ACHD patients undergoing EP procedures. Methods and Results: The population of ACHD patients undergoing transfemoral EP procedures at the University of Zurich Heart Center between January 2019 and December 2022 was observed and analyzed. During the study period, femoral access (left/right, arterial/venous) was performed under real-time… More >

  • Open Access

    ARTICLE

    Impact of Social Determinants of Health on Self-Perceived Resilience: An Exploratory Study of Two Cohorts of Adults with Congenital Heart Disease

    Albert Osom1, Krysta S. Barton2, Katie Sexton3,4, Lyndia Brumback1, Joyce P. Yi-Frazier4, Abby R. Rosenberg5,6, Ruth Engelberg7, Jill M. Steiner8,*

    Congenital Heart Disease, Vol.19, No.1, pp. 33-48, 2024, DOI:10.32604/chd.2024.046656

    Abstract Social determinants of health (SDOH) affect quality of life. We investigated SDOH impacts on self-perceived resilience among people with adult congenital heart disease (ACHD). Secondary analysis of data from two complementary studies: a survey study conducted May 2021–June 2022 and a qualitative study conducted June 2020–August 2021. Resilience was assessed through CD-RISC10 score (range 0–40, higher scores reflect greater self-perceived resilience) and interview responses. Sociodemographic and SDOH (education, employment, living situation, monetary stability, financial dependency, area deprivation index) data were collected by healthcare record review and self-report. We used linear regression with robust standard errors to analyze survey data and… More > Graphic Abstract

    Impact of Social Determinants of Health on Self-Perceived Resilience: An Exploratory Study of Two Cohorts of Adults with Congenital Heart Disease

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