Wenjie Dong^1,2,#, Zhibin Hong^1,#, Aqian Wang², Kaiyu Jiang², Hai Zhu², Fu zhang², Zhaoxia Guo², Hongling Su^2,*, Yunshan Cao^3,*

Congenital Heart Disease, Vol.19, No.3, pp. 325-339, 2024, DOI:10.32604/chd.2024.052267

Abstract Background: Current guidelines for managing pulmonary arterial hypertension (PAH) recommend a risk stratification approach. However, the applicability and accuracy of these strategies for PAH associated with congenital heart disease (PAH-CHD) require further validation. This study aims to validate the reliability and predictive accuracy of a simplified stratification strategy for PAH-CHD patients over a three-year follow-up. Additionally, new prognostic variables are identified and novel risk stratification methods are developed for assessing and managing PAH-CHD patients. Methods: This retrospective study included 126 PAH-CHD patients. Clinical and biochemical variables across risk groups were assessed using Kruskal-Wallis and Fisher’s… More > Graphic Abstract

Jiawang Xiao, Jianming Wang, Zhongchao Wang, Lili Meng, Ming Zhao, Qiguang Wang^*

Congenital Heart Disease, Vol.19, No.3, pp. 293-303, 2024, DOI:10.32604/chd.2024.051427

Abstract Background: Transcatheter closure (TCC) has emerged as the preferred treatment for selected congenital heart disease (CHD). While TCC offers benefits for patients with postoperative residual shunts, understanding its mid- and long-term efficacy and safety remains crucial. Objective: This study aims to assess the mid- and long-term safety and efficacy of TCC for patients with residual atrial or ventricular septal shunts following CHD correction. Methods: In this consecutive retrospective study, we enrolled 35 patients with residual shunt who underwent TCC or surgical repair of CHD between June 2011 to October 2022. TCC candidacy was determined based on… More >

Shuliang Xia^1,2,3,#, Huikang Tao^2,#, Shixin Su⁴, Xinxin Chen², Li Ma², Jianru Li⁵, Bei Gao⁶, Xumei Liu⁵, Lei Pi⁷, Jinqing Feng⁴, Fengxiang Li², Jia Li^4,*, Zhiwei Zhang^1,3,*

Congenital Heart Disease, Vol.19, No.2, pp. 247-256, 2024, DOI:10.32604/chd.2024.052583

Abstract Aims: Multiple genes and environmental factors are known to be involved in congenital heart disease (CHD), but epigenetic variation has received little attention. Monozygotic (MZ) twins with CHD provide a unique model for exploring this phenomenon. In order to investigate the potential role of Deoxyribonucleic Acid (DNA) methylation in CHD pathogenesis, the present study examined DNA methylation variation in MZ twins discordant for CHD, especially ventricular septal defect (VSD). Methods and Results: Using genome-wide DNA methylation profiles, we identified 4004 differentially methylated regions (DMRs) in 18 MZ twin pairs discordant for CHD, and 2826 genes were… More > Graphic Abstract

Toshi Maeda^*, Hiroki Ito, Keiichi Hirose, Kisaburo Sakamoto

Congenital Heart Disease, Vol.19, No.2, pp. 177-183, 2024, DOI:10.32604/chd.2024.050945

Abstract Congenital aortic stenosis (cAS) frequently requires intervention during the neonatal or infantile period. However, surgical repair is challenging because of the narrow surgical space. We performed bicuspidization using the open-sleeve technique for cAS with a unicuspid aortic valve in two patients. Postoperatively, the patients were doing well without reintervention for the aortic valve for 8 and 6 years, respectively. Their aortic annular diameter increased along with somatic growth. Bicuspidization for neonates or infancy can be performed safely using the open-sleeve technique as its midterm results have been satisfactory. More > Graphic Abstract

Dominique Vervoort^1,2,3,*, Amy Verstappen³, Sreehari Madhavankutty Nair⁴, Chong Chin Eu⁵, Bistra Zheleva^3,6

Congenital Heart Disease, Vol.19, No.2, pp. 131-138, 2024, DOI:10.32604/chd.2024.049814

Abstract This article has no abstract. More >

Camden L. Hebson^1,*, Kyle Bliton², Amr Y. Hammouda¹, Kaitlyn Barr³, W. Hampton Gray⁴, Mohini Gunnett², Waldemar F. Carlo¹

Congenital Heart Disease, Vol.19, No.2, pp. 185-195, 2024, DOI:10.32604/chd.2024.048871

Abstract D-transposition of the great arteries (d-TGA) is surgically repaired with the arterial switch operation (ASO) with excellent results, however short and long-term morbidities still develop including neurocognitive delay. Clinically significant central sleep apnea is uncommon in non-premature infants, but when present indicates immature autonomic control of respiration likely due to a neurologic disorder. We report the unanticipated finding of central sleep apnea in four-term neonates with d-TGA after uncomplicated ASO, with the short-term complication of delayed hospital discharge and long-term concerns regarding this early marker of brain immaturity and its hindrance to normal development. Within More >

Yang Wang^#, Xun Yang^#, Mingtang Ye, Yuhang Zhao, Runsen Chen, Min Da, Zhiqi Wang, Xuming Mo, Jirong Qi^*

Congenital Heart Disease, Vol.19, No.2, pp. 219-231, 2024, DOI:10.32604/chd.2024.048314

Abstract Congenital heart disease (CHD), the most prevalent congenital ailment, has seen advancements in the “dual indicator” screening program. This facilitates the early-stage diagnosis and treatment of children with CHD, subsequently enhancing their survival rates. While cardiac auscultation offers an objective reflection of cardiac abnormalities and function, its evaluation is significantly influenced by personal experience and external factors, rendering it susceptible to misdiagnosis and omission. In recent years, continuous progress in artificial intelligence (AI) has enabled the digital acquisition, storage, and analysis of heart sound signals, paving the way for intelligent CHD auscultation-assisted diagnostic technology. Although More > Graphic Abstract

Gustavo Cruz^1,*, Santiago Pedroza², Juan F. Vélez³, Jessica Largo², Juan F. Tejada⁴, Jorge H. Mejía-Mantilla⁵

Congenital Heart Disease, Vol.19, No.2, pp. 207-218, 2024, DOI:10.32604/chd.2024.044244

Abstract Background: Failure to rescue has been an effective quality metric in congenital heart surgery. Conversely, morbidity and mortality depend greatly on non-modifiable individual factors and have a weak correlation with better-quality performance. We aim to measure the complications, mortality, and risk factors in pediatric patients undergoing congenital heart surgery in a high-complexity institution located in a middle-income country and compare it with other institutions that have conducted a similar study. Methods: A retrospective observational study was conducted in a high-complexity service provider institution, in Cali, Colombia. All pediatric patients undergoing any congenital heart surgery between… More >

Sipawath Khamplod^1,2, Yodying Kaolawanich^1,2, Khemajira Karaketklang³, Nithima Ratanasit^1,2,*

Congenital Heart Disease, Vol.19, No.1, pp. 93-105, 2024, DOI:10.32604/chd.2024.048631

Abstract Background: Atrial septal defect (ASD) is a common form of adult congenital heart disease that can lead to long-term adverse outcomes if left untreated. Early closure of ASD has been associated with excellent outcomes and lower complication rates. However, there is limited evidence regarding the prognosis of ASD closure in older adults. This study aims to evaluate the mortality rates in older ASD patients with and without closure. Methods: A retrospective cohort study was conducted on patients aged 40 years or older with ASD between 2001 and 2017. Patients were followed up to assess all-cause… More > Graphic Abstract

Yücel Kaya^1,*, And Yavuz¹, Hasan Berkan Sayal¹, Büşra Tsakir¹, Gökalp Kabacaoğlu¹, Kadriye Nilay Özcan²

Congenital Heart Disease, Vol.19, No.1, pp. 123-129, 2024, DOI:10.32604/chd.2024.048145

Abstract Congenital ventricular aneurysm is a very rare cardiac anomaly. A diagnosis can be made during the prenatal period using fetal echocardiography. This study presents a very rare apically located left ventricular aneurysm case, and the relevant literature was reviewed and discussed. In this case, a 35-year-old, gravida 2, parity 1 pregnant woman at 24 weeks of gestation, displayed a wide aneurysmal image in the left ventricular apical wall on fetal echocardiography. There was a 1.79 mm muscular ventricular septal defect at the apical region of the interventricular septum. In the course of the color Doppler More >