Rui Jiang^1,3,*, Kaisheng Lai², Jianping Xu¹, Xiang Feng¹, Shaoye Wang¹, Xiaojian Wang³, Zhe Liu²

Congenital Heart Disease, Vol.17, No.6, pp. 675-686, 2022, DOI:10.32604/chd.2022.021626

Abstract Background: The etiology of pulmonary arterial hypertension associated with congenital heart disease (PAHCHD) is complicated and the phenotype is heterogeneous. Genetic defects of NOTCH3 were associated with cerebral disease and pulmonary hypertension. However, the relationship between NOTCH3 mutations and the clinical phenotype has not been reported in CHD-PAH. Methods: We eventually enrolled 142 PAH-CHD patients from Fuwai Hospital. Whole exome sequencing (WES) was performed to screen the rare deleterious variants of NOTCH3 gene. Results: This PAH-CHD cohort included 43 (30.3%) men and 99 (69.7%) women with the mean age 29.8 ± 10.9 years old. The pathogenic or likely pathogenic mutations… More >

Jun Sung Park¹, Go Hun Seo², Yunha Choi¹, Soojin Hwang¹, Minji Kang³, Hyo-Sang Do³, Young-Hwue Kim⁴, Jeong Jin Yu⁴, Ellen Ai-Rhan Kim⁵, Euiseok Jung⁵, Byong Sop Lee⁵, Jae Suk Baek⁴, Beom Hee Lee^1,6,*

Congenital Heart Disease, Vol.17, No.6, pp. 653-673, 2022, DOI:10.32604/chd.2022.021580

Abstract Background: Over 400 genes contribute to the development of congenital heart disease (CHD). Additionally, multisystemic manifestations accompanying syndromic CHD pose a higher risk of genetic diseases. This study investigated the diagnostic yield of whole-exome sequencing (WES) in patients with sporadic syndromic CHD and the phenotypic factors affecting the genetic diagnostic rate. Methods: Sixty-four patients with sporadic syndromic CHD aged <18 years underwent WES between May 2018 and December 2020 in a single tertiary center, and the association between genetic testing data and extracardiac phenotypes was analyzed. Results: Extracardiac phenotypes were measured as 3.66 ± 3.05 (standard deviation, interquartile range: 2–5)… More > Graphic Abstract

Shuting Chang^1,2, Guanzhao Zhang^2,3, Nengjun Sun², Xinpeng Yuan⁴, Qingting Wang⁵, Lin Zhu⁶, Feiyue Zhang⁷, Yu Xiu⁴, Yang Dong⁸, Yonghong Chen⁹, Zhanpeng Zhao¹⁰, Xiao Liu⁴, Qiang Shao¹¹, Xiaofeng Xu¹², Anshun Wang¹³, Mengjiao Li¹⁴, Bo Li^2,*

Congenital Heart Disease, Vol.17, No.6, pp. 709-716, 2022, DOI:10.32604/chd.2022.018657

Abstract Background: This study aimed to illustrate the prevalence of CHD by screening children in extremely high-altitude areas (over 4000 m to even 5000 m above sea level) and explore an aid model for early diagnosis and treatment for the Tibetan population. Methods: A total of 2242 students from different schools in Ngamring County, Xigaze city, Tibet from September 2019 to September 2020 were selected for screening. The students were examined through the inquiry of their current medical history and family history, cardiac auscultation and a physical examination, in order to screen out the suspected cases of CHD, and then the… More >

Jodi L. Feinberg¹, Peter Sheng², Stephanie Pena², Adam J. Small¹, Susanna Wendelboe¹, Katlyn Nemani³, Vikram Agrawal⁴, Dan G. Halpern^1,*

Congenital Heart Disease, Vol.17, No.5, pp. 519-531, 2022, DOI:10.32604/chd.2022.024174

Abstract Background: Adults with congenital heart disease (ACHD) have increased prevalence of mood and anxiety disorders. There are limited data regarding the influence of the COVID-19 pandemic on the mental health and health behaviors of these patients. Objective: The purpose is to evaluate the perceptions, emotions, and health behaviors of ACHD patients during the COVID-19 pandemic. Methods: In this cross-sectional study of ACHD patients, we administered surveys evaluating self-reported emotions, perceptions and health behaviors. Logistic regressions were performed to determine the adjusted odds of displaying each perception, emotion and health behavior based on predictor variables. Results: Ninety-seven patients (mean age 38.3… More > Graphic Abstract

Ying Yang^1,#, Tingting Lv^2,#, Siyuan Li¹, Ping Zhang^1,2,*

Congenital Heart Disease, Vol.17, No.5, pp. 557-567, 2022, DOI:10.32604/CHD.2021.017292

Abstract Background: T-wave alternans (TWA) is a risk factor of ventricular arrhythmias or sudden cardiac death (SCD) in patients with ischemic cardiomyopathy. Nevertheless, the relationship between TWA and adverse cardiac events (ACE) in patients with congenital long QT syndrome (LQT) remains controversial. Methods: A systematic electronic search of PubMed, Embase and the Cochrane Library was conducted from database inception dates to 28 April 2021 and assessed the relationship between TWA and ACE in patients with LQTS. Sub-group analysis evaluated the association between microvolt TWA (MTWA) and ACE in different monitoring models and ECGlead numbers. Results: A pooled analysis of seven studies… More >

Jae Hee Seol^1,4,#, Se Yong Jung^1,#, Jae Young Choi¹, Han Ki Park², Young Hwan Park², Nam Kyun Kim^1,3,*

Congenital Heart Disease, Vol.17, No.5, pp. 569-578, 2022, DOI:10.32604/chd.2022.018436

Abstract Objective: Junctional ectopic tachycardia is common after cardiac surgery for congenital heart disease. However, its incidence and related risk factors in infants after cardiac surgery are not well known. The objective of this study was to determine the overall incidence and related risk factors for junctional ectopic tachycardia in neonates and infants. Methods: We enrolled a total of 271 patients aged <1 year who underwent open cardiac surgery at Severance Cardiovascular Hospital from January 2018 to December 2020. Exclusion criteria were immediate postoperative mortality, other arrhythmias detected in the perioperative period, and prematurity. Result: The overall incidence of junctional ectopic… More >

Bingzheng Wu¹, Peizhong Liu¹, Huiling Wu², Shunlan Liu², Shaozheng He², Guorong Lv^2,3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.134, No.2, pp. 1069-1089, 2023, DOI:10.32604/cmes.2022.020870

Abstract Congenital heart defect, accounting for about 30% of congenital defects, is the most common one. Data shows that congenital heart defects have seriously affected the birth rate of healthy newborns. In Fetal and Neonatal Cardiology, medical imaging technology (2D ultrasonic, MRI) has been proved to be helpful to detect congenital defects of the fetal heart and assists sonographers in prenatal diagnosis. It is a highly complex task to recognize 2D fetal heart ultrasonic standard plane (FHUSP) manually. Compared with manual identification, automatic identification through artificial intelligence can save a lot of time, ensure the efficiency of diagnosis, and improve the… More >

Eszter Vojcek^1,2,*, V. Anna Gyarmathy^3,4, Rozsa Graf⁵, Anna M. Laszlo⁶, Laszlo Ablonczy⁷, Zsolt Prodan⁷, Istvan Seri^1,8

Congenital Heart Disease, Vol.17, No.4, pp. 447-461, 2022, DOI:10.32604/chd.2022.022274

Abstract Objective: Neonates with congenital heart disease (CHD) and perinatal stroke have high mortality and survivors are at risk for poor long-term neurodevelopmental outcome. The aim of this study was to assess the risk factors and outcome of neonates with both CHD and MRI-confirmed perinatal stroke (Study Group) and compare those to the risk factors and outcome of infants matched for CHD without stroke (Control-1) and of infants matched for MRI-confirmed stroke without CHD (Control-2). Methods: We conducted a population-based case-control study enrolling 28 term neonates with CHD and MRI-confirmed acute perinatal stroke born between 2007–2017 in the Central-Hungarian Region. Each… More > Graphic Abstract

Pornrawee Plearntummakun¹, Chodchanok Vijarnsorn^1,*, Kritvikrom Durongpisitkul¹, Prakul Chanthong¹, Paweena Chungsomprasong¹, Supaluck Kanjanauthai¹, Thita Pacharapakornpong¹, Jarupim Soongswang¹, Thaworn Subtaweesin²

Congenital Heart Disease, Vol.17, No.4, pp. 463-478, 2022, DOI:10.32604/chd.2022.021545

Abstract Background: Congenital coronary artery fistula (CCAF) is a rare anomaly. Treatment strategies tend to close the defect with a symptomatic and significant shunt, primarily based on expert consensus and case series. Results for long-term follow-up in children are limited Methods: We conducted a retrospective study to assess clinical and imaging outcomes of children with CCAF at Siriraj Hospital, Thailand during 2000–2020. Patients with single ventricle were excluded. Treatment strategies [surgical closure (SC), and percutaneous closure (PC)] were classified and the clinical outcomes at the follow-up in 2021, including coronary thrombosis, myocardial ischemia, and the results of cardiovascular imaging were reviewed.… More > Graphic Abstract

Alberto Cipriani^1,#, Pietro Bernardo Dall’Aglio^1,#, Laura Mazzotta¹, Domenico Sirico², George Sarris³, Mark Hazekamp⁴, Thierry Carrel⁵, Alessandro Frigiola⁶, Vladimir Sojak⁴, Mauro Lo Rito⁶, Jurgen Horer⁷, Regine Roussin⁷, Julie Cleuziou⁸, Bart Meyns⁹, Jose Fragata¹⁰, Helena Telles¹⁰, Anastasios C. Polimenakos¹¹, Katrien Francois¹², Altin Veshti¹³, Jukka Salminen¹⁴, Alvaro Gonzalez Rocafort¹⁵, Matej Nosal¹⁶, Eleftherios Protopapas³, Roberto Tumbarello¹⁷, Patrizio Sarto¹⁸, Cinzia Pegoraro¹⁸, Raffaella Motta¹⁹, Giovanni Di Salvo², Domenico Corrado¹, Vladimiro L. Vida¹, Massimo A. Padalino^1,2,*

Congenital Heart Disease, Vol.17, No.4, pp. 375-385, 2022, DOI:10.32604/chd.2022.019385

Abstract Background: Anomalous aortic origin of a coronary artery (AAOCA) is a congenital heart disease with a 0.3%−0.5% prevalence. Diagnosis is challenging due to nonspecific clinical presentation. Risk stratification and treatment are currently based on expert consensus and single-center case series. Methods: Demographical and clinical data of AAOCA patients from 17 tertiary-care centers were analyzed. Diagnostic imaging studies (Bidimensional echocardiography, coronary computed tomography angiography [CCTA] were collected. Clinical correlations with anomalous coronary course and origin were evaluated. Results: Data from 239 patients (42% males, mean age 15 y) affected by AAOCA were collected; 154 had AAOCA involving the right coronary artery… More > Graphic Abstract