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  • Open Access

    ARTICLE

    Cost–Utility Analysis of Pembrolizumab Versus Chemotherapy as First-Line Treatment for Metastatic Non-Small Cell Lung Cancer With Different PD-L1 Expression Levels

    Xiuhua Weng*1, Shaohong Luo*1, Shen Lin*, Lixian Zhong, Meiyue Li*, Rao Xin*, Pinfang Huang*, Xiongwei Xu*

    Oncology Research, Vol.28, No.2, pp. 117-125, 2020, DOI:10.3727/096504019X15707883083132

    Abstract To evaluate the cost–utility of pembrolizumab versus chemotherapy as the first-line setting for metastatic nonsmall cell lung cancer (NSCLC) from the US health care system perspective, a Markov model was developed to compare the lifetime cost and effectiveness of pembrolizumab versus chemotherapy for untreated metastatic NSCLC, based on the clinical data derived from phase III randomized controlled trial (KEYNOTE- 042; ClinicalTrials.gov; NCT02220894). Weibull distribution was fitted to simulate the parametric survival functions. Drug costs were collected from official websites, and utility values were obtained from published literature. Total costs, quality-adjusted life years (QALYs), and incremental… More >

  • Open Access

    ARTICLE

    Application of Low Cost Integrated Navigation System in Precision Agriculture

    Qi Wang1,2,3,*, Changsong Yang2,3,5, Yuxiang Wang1,2,3, Shao-en Wu4

    Intelligent Automation & Soft Computing, Vol.26, No.6, pp. 1433-1442, 2020, DOI:10.32604/iasc.2020.012759 - 24 December 2020

    Abstract To improve the positioning accuracy of farming vehicle in precision agriculture, an integrated positioning system is proposed based on Global Navigation Satellite System (GNSS)/Strapdown Inertial Navigation System (SINS)/Wireless Sensor Networks (WSN) with low cost and high reliability. The principles of commonly used localization technologies in vehicle positioning are compared and the Received Signal Strength Indication (RSSI) based measurement method is chosen as the integrated positioning system for information fusion considering the complexity of the algorithm, positioning accuracy and hardware requirements in the application scenario. The research of wireless signal propagation loss model of farmland environment More >

  • Open Access

    ARTICLE

    A Genetic Algorithm Optimization for Multi-Objective Multicast Routing

    Ahmed Y. Hamed1, Monagi H. Alkinani2, M. R. Hassan3,*

    Intelligent Automation & Soft Computing, Vol.26, No.6, pp. 1201-1216, 2020, DOI:10.32604/iasc.2020.012663 - 24 December 2020

    Abstract Many applications require to send information from a source node to multiple destinations nodes. To support these applications, the paper presents a multi-objective based genetic algorithm, which is used in the construction of the multicast tree for data transmission in a computer network. The proposed algorithm simultaneously optimizes total weights (cost, delay, and hop) of the multicast tree. Experimental results prove that the proposed algorithm outperforms a recently published Multi-objective Multicast Algorithm specially designed for solving the multicast routing problem. Also, the proposed approach has been applied to ten-node and twenty-node network to illustrate its More >

  • Open Access

    ARTICLE

    Cost Optimized Non-Contacting Experimental Modal Analysis Using a Smartphone

    Jaafar Hallal1,2,3,*, Mohammad Hammoud2,3, Mahmoud Fakih2,3,4, Ali Hallal2,3

    Sound & Vibration, Vol.54, No.4, pp. 225-236, 2020, DOI:10.32604/sv.2020.011513 - 25 November 2020

    Abstract The vibrations behavior analysis is an essential step in the mechanical design process. Several methods such as analytical modelling, numerical analysis and experimental measurements can be used for this purpose. However, the numerical or analytical models should be validated through experimental measurements, usually expensive. This paper introduces an inexpensive smartphone as an accurate, non-intrusive vibrations’ behavior measurement device. An experimental measurement procedure based on the video processing method is presented. This procedure allows the measurement of the natural frequencies and the mode shapes of a vibrating structure, simply by using a smartphone built-in camera. The… More >

  • Open Access

    ARTICLE

    Long-Term Healthcare Utilization, Medical Cost, and Societal Cost in Adult Congenital Heart Disease

    Ruben Willems1,*, Fouke Ombelet2, Eva Goossens2,3,4, Katya De Groote5, Werner Budts6,7, Stéphane Moniotte8, Michèle de Hosson9, Liesbet Van Bulck2,4, Arianne Marelli10, Philip Moons2,11,12, Julie De Backer4,9,#, Lieven Annemans1,#

    Congenital Heart Disease, Vol.15, No.6, pp. 399-429, 2020, DOI:10.32604/CHD.2020.011709 - 02 November 2020

    Abstract Objective: Cost-of-illness studies in Adult Congenital Heart Disease (ACHD) have mainly been limited to hospitalizations. This is the first paper to provide a comprehensive overview from a societal perspective including inpatient and outpatient medical costs, and absenteeism- and unemployment-related societal costs. Methods: A retrospective longitudinal (2006–2015) database analysis was performed in Belgium combining administrative and clinical databases (n = 10,572). Trends in resource use and costs per patient year were standardized to assess the impact of changes in the patient population composition. Generalized Linear Mixed Models assessed the impact of age, sex, lesion complexity, and time.… More >

  • Open Access

    ARTICLE

    Research on Distribution Network Full Cost-Benefit Optimization Considering Different Renewable Energy Penetration

    Tanzhong Fu1,2,3, Yu Xue1,*, Tancai Xia1, Wang Jing1, De Gejirifu1

    Energy Engineering, Vol.117, No.6, pp. 397-411, 2020, DOI:10.32604/EE.2020.011633 - 16 October 2020

    Abstract To further study the impact of renewable energy penetration on the technical transformation of distribution networks. Based on the output power characteristics of wind power and photovoltaics, a renewable energy grid-connected capacity model and a distribution network full cost-benefit model were constructed. Based on this, to maximize the comprehensive income of the distribution network and the renewable energy penetration rate, to establish the technical reform optimization model and search for the optimal solution through the improved NSGA-II algorithm. Finally, the effectiveness of the proposed model was verified by setting up three scenarios of simultaneous wind More >

  • Open Access

    ARTICLE

    Research on the Development of Project Cost Informatization in the Era of Big Data

    Huiyu Long1, Yan Ma1, Xiang Mao1, Xinyuerong Sun2,*

    Journal on Big Data, Vol.2, No.2, pp. 63-70, 2020, DOI:10.32604/jbd.2020.011214 - 18 September 2020

    Abstract Under the background of big data, Informatization plays an important role in the development of the engineering cost industry. The rapid development of the industry and the increasing complexity of construction projects require higher standards of informatization. The current information processing methods and models have been difficultly to meet new requirements. Based on this, this study deeply analyzes the key factors that impede the informatization of engineering cost development, and tries to find corresponding solutions through theoretical analysis and empirical research to break these constraints. This will play a guiding role in the development of More >

  • Open Access

    ARTICLE

    Cost Effective Smart System for Water Pollution Control with Underwater Wireless Sensor Networks: A Simulation Study

    Muhammed Enes Bayrakdar

    Computer Systems Science and Engineering, Vol.35, No.4, pp. 283-292, 2020, DOI:10.32604/csse.2020.35.283

    Abstract The underwater sensor network is a rapidly developing area of research with a wide range of applications such as data collection in the ocean, pollution monitoring, and ocean sampling. One of the most researched areas is the coverage of underwater sensor networks, which are the basis of many applications. The coverage is usually related to how effectively a network is monitored by the sensor. There are major problems in the ocean or marine region, especially in water pollution. Underwater pollution generally causes acidification, plastic residues, and toxins. Today, the determination of this pollution is carried More >

  • Open Access

    ARTICLE

    Research on the Product Logistics Cost Control Strategy Based on the Multi-Source Supply Chain Theory

    Chun Di*

    Intelligent Automation & Soft Computing, Vol.26, No.3, pp. 557-567, 2020, DOI:10.32604/iasc.2020.013934

    Abstract In response to the rapidly changing market environment and adapting to many impacts such as political, economic and technological conditions, supply chain managers are increasingly demanding a high-speed and efficient way to adjust the design to optimize the supply chain structure. In order to facilitate the participating companies in the supply chain to quickly and effectively implement the supply chain design optimization strategy, improve the competitiveness of enterprises and the ability of the entire supply chain to resist risks. Enterprises have gradually reduced the space for enhancing the competitive advantage by reducing raw material consumption,… More >

  • Open Access

    ARTICLE

    Performance and Cost Analysis of Energy Production from Offshore Wind Turbines

    Haytham Ayoub, Ehab Hussein Bani-Hani*

    Energy Engineering, Vol.117, No.1, pp. 41-47, 2020, DOI:10.32604/EE.2020.010412 - 28 February 2020

    Abstract Offshore wind turbine is analyzed theoretically and experimentally for improving wind energy harvesting. The energy produced is calculated at different wind speeds. The wind speed curve is generated by measuring the wind speed on daily base for one year. Curves that show the power extraction for experimental study and from the theoretical calculations are generated. The energy production investigation is expanded over a period of 15 years after comparing the annual energy production in theory and practice. The study shows the cost of electricity over the same time period assuming different interest rates. Three time… More >

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