Chuncheng Liu1, Xiaohan Liu1, Ziqi Li1, Yanruoxue Wei1, Bangdong Liu2, Peng Zhu2, Yukun Liu1,2,*, Ran Zhao1,2,*
Oncology Research, Vol.33, No.8, pp. 2085-2105, 2025, DOI:10.32604/or.2025.065739
- 18 July 2025
Abstract Background: VPS37A (VPS37A subunit of ESCRT-I), a component of the ESCRT-I (endosomal sorting complex required for transport I) complex, mediates vesicular trafficking through sorting endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Although accumulating evidence indicates that VPS37A deficiency occurs in numerous malignancies and exerts tumor-suppressive effects during cancer progression, its functional significance in colorectal cancer (CRC) pathogenesis remains poorly characterized. Therefore, this study aims to further investigate the functional and molecular mechanisms by which VPS37A downregulation contributes to malignant biological phenotypes in CRC, with a specific focus on how its dysregulation affects cell death pathways.… More >
Graphic Abstract