Ravita Chahar, Ashutosh Kumar Dubey^*

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-65, 2026, DOI:10.32604/cmc.2025.066990 - 10 November 2025

Abstract Objective: The increasing global prevalence of mental health disorders highlights the urgent need for the development of innovative diagnostic methods. Conditions such as anxiety, depression, stress, bipolar disorder (BD), and autism spectrum disorder (ASD) frequently arise from the complex interplay of demographic, biological, and socioeconomic factors, resulting in aggravated symptoms. This review investigates machine intelligence approaches for the early detection and prediction of mental health conditions. Methods: The preferred reporting items for systematic reviews and meta-analyses (PRISMA) framework was employed to conduct a systematic review and analysis covering the period 2018 to 2025. The potential… More >

Siti Rahayu Nadhiroh^1,*, Ira Nurmala², Iqbal Pramukti³, Kamolthip Ruckwongpatr⁴, Laila Wahyuning Tyas², Afina Puspita Zari², Warda Eka Islamiah¹, Yan-Li Siaw⁵, Marc N. Potenza^{6,7,8,9,10,11}, Chung-Ying Lin^{12,13,14,15,*}

International Journal of Mental Health Promotion, Vol.27, No.12, pp. 1847-1865, 2025, DOI:10.32604/ijmhp.2025.072115 - 31 December 2025

Abstract Objectives: Problematic use of the internet (PUI) has been increasingly associated with various mental health issues, highlighting the need for accurate assessment tools. The Assessment of Criteria for Specific Internet-use Disorder (ACSID-11) is a validated psychometric instrument designed to measure distinct forms of PUI across multiple online activities. However, its applicability and validity have not yet been established within the Indonesian context. Therefore, this study aimed to translate and validate the ACSID-11 for use among Indonesian populations. Methods: The translation procedure of the ACSID-11 involved forward translation, back translation, and expert panel discussions. This research involved… More >

Carmen Rubio^1,#, Norma Serrano-GarcíA^1,#, Elisa Taddei¹, Eduardo CastañEda², HéCtor Romo^1,3, MoiséS Rubio-Osornio^4,*

BIOCELL, Vol.49, No.8, pp. 1391-1412, 2025, DOI:10.32604/biocell.2025.066320 - 29 August 2025

Abstract Rotenone is a lipophilic herbicide extensively utilized in experimental neurodegenerative models because of its capacity to disrupt complex I of the mitochondrial electron transport chain. This inhibition results in reduced ATP synthesis, elevated reactive oxygen species (ROS) formation, and mitochondrial malfunction, which instigates oxidative stress and cellular damage, critical elements in neurodegenerative disorders like Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and Alzheimer’s disease (AD). In addition to causing direct neuronal injury, rotenone significantly contributes to the activation of glial cells, specifically microglia and astrocytes. Activated microglia assumes a proinflammatory (M1) phenotype, distinguished by the… More >

Kumudesh Mishra^1,2,*, Or Kakhlon^1,2

BIOCELL, Vol.49, No.7, pp. 1101-1123, 2025, DOI:10.32604/biocell.2025.061725 - 25 July 2025

Abstract Mitochondria are central organelles in cellular metabolism, orchestrating energy production, biosynthetic pathways, and signaling networks. Nicotinamide adenine dinucleotide (NAD⁺) and its reduced form (NADH) are essential for mitochondrial metabolism, functioning both as redox coenzymes and as signaling agents that help regulate cellular balance. Thus, while its major role is in energy production, NAD⁺ is widely recognized as a metabolic cofactor and also serves as a substrate for various enzymes involved in cellular signaling, like sirtuins (SIRTs), poly (ADP-ribosyl) polymerases (PARPs), mono (ADP-ribosyl) transferases, and CD38. Sirtuins, a family of NAD⁺-dependent deacetylases, are critical in this regulatory network.… More >

Wiktoria Staśkiewicz-Bartecka^1,*, Samet Aktaş², Grzegorz Zydek³, Marek Kardas¹, Oskar Kowalski⁴

International Journal of Mental Health Promotion, Vol.27, No.5, pp. 649-665, 2025, DOI:10.32604/ijmhp.2025.064543 - 05 June 2025

Abstract Background: In light of growing concern over eating disorders among young athletes amid cultural and social pressures, this study aimed to assess the prevalence of orthorexia nervosa (ON) risk and evaluate body image perception and its predictive factors among young football players from Poland and Türkiye. Methods: The study involved 171 players aged 15–18 years, recruited from football academies in Poland and Türkiye. The Polish and Turkish versions of the Body-Esteem Scale for Adolescents and Adults (BESAA) were administered to assess body image perception, while the Düsseldorf Orthorexia Scale (DOS) was used to measure ON… More >

Daniel Lesiba Letsoalo^1,*, Mahlatsi Venolia Semenya², Anastasia Julia Ngobe¹, Joy Katlego Hlokwe¹

Journal of Psychology in Africa, Vol.35, No.1, pp. 159-165, 2025, DOI:10.32604/jpa.2025.065764 - 30 April 2025

Abstract There has been an increase in mental health problems in Sub-Saharan Africa. Considering this, it is critical to track the region’s level of mental health literacy (MHL) to identify key mental health priorities and to direct the most effective interventions. The purpose of this study was to review the existing literature on MHL in sub-Saharan Africa. EBSCOhost (inclusive of Academic Search Ultimate, MEDLINE, APA PsycINFO, APA Psych Articles, and Global Health), CINAHL with full text, Wiley Online Library, Taylor and Francis Online Journals and Google Scholar databases were searched to retrieve relevant articles. The study… More >

José Antonio Climent-Rodríguez¹, Inmaculada González-Lepe², Juan Gómez-Salgado^3,4,*, Yolanda Navarro-Abal¹

International Journal of Mental Health Promotion, Vol.27, No.4, pp. 507-515, 2025, DOI:10.32604/ijmhp.2025.063497 - 30 April 2025

Abstract Background: Employment can support the recovery of individuals with Severe Mental Disorders by promoting autonomy, reducing hospital admissions and associated costs, fostering social connections, and providing structure to their daily lives. The objective of this pilot study was to analyse job satisfaction and perceived social support in people with severe mental disorders who are users of an Employment Guidance and Support Service in southern Spain. Methods: A descriptive cross-sectional pilot study was carried out with a sample of 39 workers with mental disorders from the province of Huelva (southern Spain) who were users of the… More >

YONG RAO^1,3,4, XIAO CHEN^5,6, KAIYU LI^1,3,4, MINHAI NIE^1,3,4, XUQIAN LIU^2,3,4,*

Oncology Research, Vol.33, No.3, pp. 577-590, 2025, DOI:10.32604/or.2024.053119 - 28 February 2025

Abstract Decorin (DCN) is primarily found in the connective tissues of various parts of the body, including the lungs, kidneys, bone tissue, aorta, and tendons. It is an important component of the extracellular matrix (ECM) and belongs to the class I small leucine-rich proteoglycans family. DCN is increasingly attracting attention due to its significant role in tumors, fibrotic diseases, and the regulation of vascular formation. Moreover, its anti-tumor properties have positioned it as a promising biomarker in the fight against cancer. Numerous studies have confirmed that DCN can exert inhibitory effects in various solid tumors, particularly… More >

RENATA DA SILVA CARNEIRO¹, MATEUS HENRIQUE DE ALMEIDA DA COSTA¹, JOSé ZILTON LIMA VERDE SANTOS¹, VALDILéIA TEIXEIRA UCHôA², LUCIANO DA SILVA LOPES³, ANDERSON NOGUEIRA MENDES^1,*

BIOCELL, Vol.49, No.1, pp. 109-125, 2025, DOI:10.32604/biocell.2024.058405 - 24 January 2025

Abstract Neurodegenerative diseases are a major public health challenge, mainly affecting the elderly population and compromising their cognitive, sensory, and motor functions. Currently, available therapies focus on alleviating symptoms and slowing the progression of these conditions, but they do not yet offer a definitive cure. In this scenario, terpenes emerge as promising natural alternatives due to their neuroprotective properties. These compounds can reduce the formation of protein aggregates, neutralize free radicals, and inhibit pro-inflammatory enzymes, which are crucial factors in the development of neurodegenerative diseases. In addition, terpenes also play an important role in the… More >

SHUOCHEN PANG¹, TAO JIA^1,*, ZIFENG YANG^2,*

BIOCELL, Vol.48, No.12, pp. 1721-1734, 2024, DOI:10.32604/biocell.2024.055753 - 30 December 2024

Abstract The Receptor for Advanced Glycation End Products (RAGE) is a multiligand receptor of the immunoglobulin superfamily, notably highly expressed in the lungs. Its interaction with a variety of ligands, including advanced glycation end products (AGEs), S100 proteins, and high mobility group box 1 (HMGB1), activates multiple signaling pathways that are pivotal in the pathogenesis of numerous pulmonary diseases and comorbidities. However, comprehensive reviews on the role of ligands-RAGE signaling in specific lung diseases are rare. This review aims to elucidate the mechanisms by which RAGE-mediated signaling pathways either provide protective or pathogenic effects in pulmonary More >