MOHAMED AGHYAD AL KABBANI^1,2, GILBERT WUNDERLICH^3,4, CHRISTOPH KöHLER⁵, HANS ZEMPEL^1,2,*

BIOCELL, Vol.46, No.4, pp. 847-853, 2022, DOI:10.32604/biocell.2022.018144

Abstract Tauopathies comprise a spectrum of genetic and sporadic neurodegenerative diseases mainly characterized by the presence of hyperphosphorylated TAU protein aggregations in neurons or glia. Gene therapy, in particular adeno-associated virus (AAV)-based, is an effective medical approach for difficult-to-treat genetic diseases for which there are no convincing traditional therapies, such as tauopathies. Employing AAV-based gene therapy to treat, in particular, genetic tauopathies has many potential therapeutic benefits, but also drawbacks which need to be addressed in order to successfully and efficiently adapt this still unconventional therapy for the various types of tauopathies. In this Viewpoint, we briefly introduce some potentially treatable… More >

Jaswinder Kaur¹, Manish Vyas², Joginder Singh¹, Ram Prasad^3,*, Jeena Gupta^1,*

Phyton-International Journal of Experimental Botany, Vol.89, No.4, pp. 795-803, 2020, DOI:10.32604/phyton.2020.09420

Abstract In recent years, there has been an increase in epidemiological studies to highlight the health benefits of plant secondary metabolites. Flavonoids (polyphenolic plant secondary metabolites) are recently emerging as an important source for the discovery of new drugs increasing their pharmaceuticals, nutraceutical and medicinal applications. Naringenin is a flavanone, enriched in citrus fruits, tomatoes, bergamot, etc. which has been evaluated extensively for managing diabetes. However, in addition to this, naringenin had been ascribed to various important biological activities like antioxidant, antiviral, anticancer, anti-inflammatory, antiestrogenic, etc. This article aims at highlighting the therapeutic value of naringenin in managing disorders other than… More >

Haoliang Zhang^1,*, Xiaowei Xing², Yang Liu¹, Shuangli Li¹, Weiyuan Li³

Oncologie, Vol.22, No.2, pp. 107-116, 2020, DOI:10.32604/oncologie.2020.012494

Abstract Lung cancer is the leading cause of death in cancer patients. Based on a modular and comprehensive analysis method, it is intended to identify their common pathogenesis. We downloaded data and analyzed differences in lung adenocarcinoma samples, lung squamous cell carcinoma samples, and normal samples. Co-expression analysis, enrichment analysis, and hypergeometric testing were used to predict transcription factors, ncRNAs, and retrospective target genes. We get 4596 differentially expressed genes in common differences in high multiples and clustered into 14 modules dysfunction. The 14 genes (including DOK2, COL5A1, and TSPAN8) have the highest connectivity in the dysfunction module and are identified… More >

Sebastian Udholm¹, Camilla Nyboe¹, Thomas Meinertz Dantoft², Torben Jørgensen^2,3,4, Charlotte U. Rask⁵, Vibeke E. Hjortdal¹

Congenital Heart Disease, Vol.14, No.5, pp. 803-810, 2019, DOI:10.1111/chd.12808

Abstract Objective: For the first time, we wish to assess the psychiatric burden in adult patients living with small, unrepaired atrial septal defects (ASD) using register‐based data, com‐ bined with self‐reported measures on levels emotional distress and educational status.
Design: A descriptive study using both the unique Danish registries and validated psychiatric questionnaires and scales, including: The Symptom Checklist, Whiteley‐7, and Brief Illness Perception Questionnaire.
Patients: Adult patients with small, unrepairedASD, diagnosed between 1953 and 2011.
Outcome Measures: Number of register‐based psychiatric diagnoses. Additionally, symptoms of anxiety, depression, somatization, health anxiety, illness perception, and levels of educational attainment compared to age‐… More >

Batool Mousavi^1,*, Marziye Asgari², Mohammadreza Soroush², Reza Amini³, Ali Montazeri⁴

International Journal of Mental Health Promotion, Vol.22, No.1, pp. 11-17, 2020, DOI:10.32604/IJMHP.2020.010901

Abstract Mental disorders tend to be highly prevalent in war survivors. This paper examined the long-term impact of psychiatric disorders of war survivors on the level of health vulnerability among their female spouses. Interviews were conducted with a nationally representative sample of 653 of the partners of male war survivors with disabilities. The war survivors’ database information used to determine the presence of psychiatric disorders. Then the partners of survivors with (N = 333) and without (N = 320) psychological disorders were assessed via the health-related quality of life (HRQOL-SF36) questionnaire. The frequency of depression and PTSD in war survivors suffer… More >

Kailyn Anderson¹, James Cnota^2,3, Jeanne James^4,5, Erin M. Miller^2,3, Ashley Parrott³, Valentina Pilipenko^1,2, Kathryn Nicole Weaver^1,2, Amy Shikany³

Congenital Heart Disease, Vol.14, No.2, pp. 264-273, 2019, DOI:10.1111/chd.12721

Abstract Objective: To evaluate the prevalence of Noonan spectrum disorders (NSD) in a pediatric population with valvar pulmonary stenosis (vPS) and identify the clinical characteristics that differentiate those with NSD from those without NSD.
Design: A retrospective chart review of 204 patients diagnosed with vPS between 9/1/2012 and 12/1/2016 at a pediatric medical center was performed. The quantitative features of vPS, genetic diagnosis information, and phenotypic characteristics of Noonan syndrome were collected. Chi‐square test, Fisher’s exact test, t test, Wilcoxon rank‐sum test, and ANOVA were used for comparisons among the groups. Logistic regression was used to test for the association between… More >