Home / Advanced Search

  • Title/Keywords

  • Author/Affliations

  • Journal

  • Article Type

  • Start Year

  • End Year

Update SearchingClear
  • Articles
  • Online
Search Results (7)
  • Open Access


    Toward Improved Accuracy in Quasi-Static Elastography Using Deep Learning

    Yue Mei1,2,3, Jianwei Deng1,2, Dongmei Zhao1,2, Changjiang Xiao1,2, Tianhang Wang4, Li Dong5, Xuefeng Zhu1,6,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.1, pp. 911-935, 2024, DOI:10.32604/cmes.2023.043810

    Abstract Elastography is a non-invasive medical imaging technique to map the spatial variation of elastic properties of soft tissues. The quality of reconstruction results in elastography is highly sensitive to the noise induced by imaging measurements and processing. To address this issue, we propose a deep learning (DL) model based on conditional Generative Adversarial Networks (cGANs) to improve the quality of nonhomogeneous shear modulus reconstruction. To train this model, we generated a synthetic displacement field with finite element simulation under known nonhomogeneous shear modulus distribution. Both the simulated and experimental displacement fields are used to validate More >

  • Open Access


    Study on the Value of Ultrasound Elastography Combined with Plasma miRNA Expression in the Early Detection of Breast Cancer

    Qian Zhang1,2,#, Yuanyuan Cao2,#, Mingming Fang3, Qin Yang2, Pingyang Zhang1,*

    Oncologie, Vol.24, No.4, pp. 717-727, 2022, DOI:10.32604/oncologie.2022.026998

    Abstract Background: Breast cancer (BC) is the most common malignant tumor in women, and its morbidity and mortality are increasing each year, due to the lack of specific clinical symptoms in the early stage of BC, and the lack of diagnostic methods for early breast cancer. Therefore, identifying an effective diagnostic method for early BC has become urgent. Materials and Methods: Breast lesions with a histological diagnosis that were examined by ultrasonic elastography (UE) in our department from June 2020 to December 2021 were reviewed. qRT-PCR was performed to measure the expression levels of miR-144-5p and miR-26b-5p in… More >

  • Open Access


    Evaluation of Fontan liver disease: Correlation of transjugular liver biopsy with magnetic resonance and hemodynamics

    Jose A. Silva‐Sepulveda1, Yudy Fonseca2, Irine Vodkin3, Gabrielle Vaughn1, Robert Newbury4, Vera Vavinskaya5, Jerry Dwek6, James C. Perry1, Preeti Reshamwala7, Cynthia Baehling8, James Lyon9, Christopher Davis1, Jesse W. Lee1, Hannah El‐Sabrout10, Doaa Shahbah11, Laith Alshawabkeh12, John W Moore1, Howaida El‐Said1

    Congenital Heart Disease, Vol.14, No.4, pp. 600-608, 2019, DOI:10.1111/chd.12770

    Abstract Introduction: Liver fibrosis and cirrhosis are late complications in Fontan palliation. Liver biopsy is the gold standard. The goal of this study is to correlate transjugular liver biopsy (TJLB) in the setting of Fontan palliation with noninvasive testing and hemodynamics.
    Methods: Between August 2014 and July 2017, 49 Fontan patients underwent TJLB. All the patients had hemodynamic evaluation, 28 patients had MRE (magnetic reso‐ nance elastography) and 40 patients had cardiopulmonary exercise test. Histologic liver fibrosis was quantitated using traditional histologic scoring systems and a modi‐ fied Ishak congestive hepatic fibrosis score.
    Results: Median age 17.8 years, median… More >

  • Open Access


    FibroSURE and elastography poorly predict the severity of liver fibrosis in Fontan-associated liver disease

    Jessica L. Schachter1, Manisha Patel2, Samuel R. Horton3, A. Mike Devane4, Alex Ewing5, Gary A. Abrams6

    Congenital Heart Disease, Vol.13, No.5, pp. 764-770, 2018, DOI:10.1111/chd.12650

    Abstract Objective: As the population of patients with Fontan circulation surviving into adult‐ hood increases, hepatic cirrhosis has grown to be a significant cause of morbidity and mortality. Early detection of advanced hepatic fibrosis is imperative for proper inter‐ vention and consideration for heart or combined heart/liver transplantation. Noninvasive biomarkers and elastography have been evaluated for their diagnostic utility with variable results in the Fontan population.
    Design: The cohort included 14 patients age 26.4 SD 7.5 who underwent Fontan surgery. All patients were evaluated with FibroSURE, shear wave elastography (SWE), hepatic duplex sonography, and liver biopsy. Liver fibrosis… More >

  • Open Access


    Acoustic radiation force impulse of the liver after Fontan operation: Correlation with cardiopulmonary exercise test

    Michael V. Di Maria1, Lindsey Silverman2, Adel K. Younoszai1, Mariana L. Meyers3, Kelley E. Capocelli4, Michael R. Narkewicz5

    Congenital Heart Disease, Vol.13, No.3, pp. 444-449, 2018, DOI:10.1111/chd.12594

    Abstract Background: The current management paradigm for children with single ventricle heart disease involves a series of palliative surgeries, culminating in the Fontan operation. This physiology results in a high central venous pressure, and in the setting of single ventricle heart disease, results in hepatic injury and fibrosis over time. Fontan-associated liver disease (FALD) is universally present in this cohort, and the current gold standard for diagnosis remains biopsy. Noninvasive assessments of liver fibrosis, such as ultrasound with elastography or acoustic radiation force impulse (ARFI), has been utilized in this cohort. The effect of poor cardiovascular efficiency,… More >

  • Open Access


    A composite noninvasive index correlates with liver fibrosis scores in post-Fontan patients: Preliminary findings

    William N. Evans1,2, Ruben J. Acherman1,2, Michael L. Ciccolo1,3, Sergio A. Carrillo1,2, Alvaro Galindo1,2, Abraham Rothman1,2, Gary A. Mayman1,2, Elizabeth A. Adams1,2, Leigh C. Reardon1,4, Brody J. Winn5, Noel S. Yumiaco5, Lesley Shimuizu1, Yoko Inanaga1, Rowena J. Deleon1, Humberto Restrepo1,2

    Congenital Heart Disease, Vol.13, No.1, pp. 38-45, 2018, DOI:10.1111/chd.12558

    Abstract Objective: We hypothesized that clinic-based, hepatic-ultrasound, elastography measurements, either alone or in combination with other noninvasive variables, might correlate with liver-biopsy fibrosis scores in patients post-Fontan.
    Methods: Between March 2012 and February 2017, we identified patients post-Fontan that underwent elective cardiac catheterization and simultaneous transvenous hepatic biopsy. From this group, we selected patients that met inclusion criteria for liver-ultrasound, shear-wave elastography. Utilizing the results of elastography, laboratory testing, and time post-Fontan, we constructed a composite Fontan hepatic index as a sum of elastography measurements in kilopascals, model for end-stage liver disease excluding INR scores, and the square… More >

  • Open Access


    Mechanics Based Tomography Using Camera Images

    Sevan Goenezen1,*, Ping Luo1, Baik Jin Kim1, Maulik Kotecha1, Yue Mei2,3

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 46-48, 2019, DOI:10.32604/mcb.2019.07348

    Abstract It is well known that the mechanical properties of tissues may vary spatially due to changing tissue types or due to inherent tissue disease. For example, the biomechanical properties are known to vary throughout blood vessels [1]. Diseases such as cancers may also lead to locally altered mechanical properties, thus allow a preliminary diagnosis via finger palpation. Quantifying the mechanical property distribution of tissues for a given constitutive equation will allow to characterize the biomechanical response of tissues. This may help to 1) predict disease progression, 2) diagnose diseases that alter the biomechanics of the… More >

Displaying 1-10 on page 1 of 7. Per Page