Alexander Blagov1,*, Michael Bukrinsky2, Aleksandra Utkina3, Gulalek Babayeva4, Vasily Sukhorukov1, Alexander Orekhov5
BIOCELL, Vol.49, No.7, pp. 1125-1140, 2025, DOI:10.32604/biocell.2025.062821
- 25 July 2025
Abstract Eosinophils are multifunctional granulocytes that contribute to the initiation and modulation of inflammation. Accumulating evidence suggests that eosinophils are adaptable leukocytes that orchestrate the resolution of inflammatory responses. The most prevalent chronic inflammatory illness, rheumatoid arthritis (RA), is typified by persistent synovitis that makes it hard for the disease to go away on its own. Interestingly, a unique subset of eosinophils known as regulatory eosinophils has been found in RA patients’ synovium, especially while the disease is in remission. Pro-resolving signatures of regulatory eosinophils in the synovium are distinct from those of their lung counterparts. More >