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  • Open Access


    The DMRTA1-SOX2 positive feedback loop promotes progression and chemotherapy resistance of esophageal squamous cell carcinoma


    Oncology Research, Vol.31, No.6, pp. 887-897, 2023, DOI:10.32604/or.2023.030184

    Abstract Esophageal squamous cell carcinoma (ESCC) is among the most prevalent causes of cancer-related death in patients worldwide. Resistance to immunotherapy and chemotherapy results in worse survival outcomes in ESCC. It is urgent to explore the underlying molecular mechanism of immune evasion and chemoresistance in ESCC. Here, we conducted RNA-sequencing analysis in ten ESCC tissues from cisplatin-based neoadjuvant chemotherapy patients. We found that DMRTA1 was extremely upregulated in the non-pathologic complete response (non-pCR) group. The proliferation rate of esophageal squamous carcinoma cells was markedly decreased after knockdown of DMRTA1 expression, which could increase cisplatin sensitivity in ESCC. Additionally, suppression of DMRTA1… More >

  • Open Access


    Scaffold proteins of cancer signaling networks: The paradigm of FK506 binding protein 51 (FKBP51) supporting tumor intrinsic properties and immune escape


    Oncology Research, Vol.31, No.4, pp. 423-436, 2023, DOI:10.32604/or.2023.028392

    Abstract Scaffold proteins are crucial regulators of signaling networks, and their abnormal expression may favor the development of tumors. Among the scaffold proteins, immunophilin covers a unique role as ‘protein-philin’ (Greek ‘philin’ = friend) that interacts with proteins to guide their proper assembly. The growing list of human syndromes associated with the immunophilin defect underscores the biological relevance of these proteins that are largely opportunistically exploited by cancer cells to support and enable the tumor’s intrinsic properties. Among the members of the immunophilin family, the FKBP5 gene was the only one identified to have a splicing variant. Cancer cells impose unique… More > Graphic Abstract

    Scaffold proteins of cancer signaling networks: The paradigm of FK506 binding protein 51 (FKBP51) supporting tumor intrinsic properties and immune escape

  • Open Access


    Randomized MILP framework for Securing Virtual Machines from Malware Attacks

    R. Mangalagowri1,*, Revathi Venkataraman2

    Intelligent Automation & Soft Computing, Vol.35, No.2, pp. 1565-1580, 2023, DOI:10.32604/iasc.2023.026360

    Abstract Cloud computing involves remote server deployments with public network infrastructures that allow clients to access computational resources. Virtual Machines (VMs) are supplied on requests and launched without interactions from service providers. Intruders can target these servers and establish malicious connections on VMs for carrying out attacks on other clustered VMs. The existing system has issues with execution time and false-positive rates. Hence, the overall system performance is degraded considerably. The proposed approach is designed to eliminate Cross-VM side attacks and VM escape and hide the server’s position so that the opponent cannot track the target server beyond a certain point.… More >

  • Open Access


    A Fire Escape Simulation System Based on the Dijkstra Algorithm

    Haolong Yang1, Chunqiang Hu1, Guwei Li2,*, Jingchun Fan3

    Computer Systems Science and Engineering, Vol.39, No.3, pp. 365-372, 2021, DOI:10.32604/csse.2021.016377

    Abstract Despite the support of all kinds of fire prevention measures and high-tech fire prevention equipment, fires still occur frequently because of both anthropogenic factors and natural disasters. This issue has drawn the attention of schools, all levels of government, and other organizations. Many types of organizations carry out fire drills throughout the year. Because this kind of drill cannot anticipate the specific circumstances of each fire, which are generally far more complicated than drills, most people cannot correctly choose the optimal escape route from real fires. Thus, a fire-scene virtual simulation system based on the Dijkstra algorithm is here proposed… More >

  • Open Access


    Mechanisms adopted by cancer cells to escape apoptosis–A review


    BIOCELL, Vol.45, No.4, pp. 863-884, 2021, DOI:10.32604/biocell.2021.013993

    Abstract Inactivation of apoptosis is the prime phenomenon in cancer development and cancer treatments. Mutations in the apoptotic pathway not only exert resistance to apoptosis and provide a survival advantage to cancer cells but also confer resistance to cancer therapies. Escaping apoptosis is the “hallmark” of cancer cells. Cancer cells can withstand many apoptotic stimuli, such as DNA damage, unfavorable environments, and cytotoxic therapies. Substantial research has been carried out and is in good progress on the various mechanisms adopted by cancer cells to evade apoptosis. This article reviews the apoptosis escape mechanisms by cancer cells, viz. apoptotic gene alterations (in… More >

  • Open Access


    Fundamentals of Digestive Cancers Immunology, Especially Gastric and Hepatocellular Carcinomas
    Fondamentaux de l’immunologie des Cancers Digestifs (Gastriques et Hépatocellulaires)

    Pierre-Guillaume Poureau1,2,*, Jean-Philippe Metges2

    Oncologie, Vol.23, No.1, pp. 47-59, 2021, DOI:10.32604/Oncologie.2021.15525

    Abstract Immunotherapy for digestive cancers is booming and for the first time an immune checkpoint inhibitor has been granted marketing authorization for the treatment of digestive cancer. In order to better understand the mecanism of action of these treatments, their adverse events and the escape mecansim, it is necessary to know the fundamentals of cancer immunology. The innate and adaptive immune system allows the elimination of cancer cells by direct non-specific cytotoxicity (Natural Killer cells), by the development of an adaptive cell-mediated response (dendritic cells becoming antigen presenting cells, allowing the differentiation of lymphocytes naive in CD4 and CD8 T lymphocytes)… More >

  • Open Access


    Numerical Simulation of Fire-Smoke Diffusion Caused by Vehicles in a Tunnel

    Li Lei*, Wukai Chen, Huiling Li, Shuai Shi

    FDMP-Fluid Dynamics & Materials Processing, Vol.16, No.5, pp. 837-856, 2020, DOI:10.32604/fdmp.2020.09631

    Abstract Urban tunnels are generally narrow and fire smoke can hardly diffuse. In the present study, numerical simulation is used to analyze the diffusion of high temperature smoke produced by fire inside a specific tunnel (the Kaiyuan tunnel). The results are compared with similar data relating to other tests to determine the validity of the numerical method. Moreover, the critical velocity obtained by numerical simulation of 5 MW, 20 MW, and 50 MW fires in curved and linear sections of the considered tunnel is compared with the values obtained using empirical formulas. The results show that, for the tunnel ventilation design,… More >

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