Lv Ling^1,#, Minying Lu^2,#, Ling Ye³, Yuanhang Chen², Sheng Lin², Jun Yang², Yu Rong^2,*, Guixiong Wu^4,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069889 - 30 December 2025

Abstract Background: A significant proportion of patients still cannot benefit from existing targeted therapies and immunotherapies, making the search for new treatment strategies extremely urgent. In this study, we combined integrate public data analysis with experimental validation to identify novel prognostic biomarkers and therapeutic targets for lung adenocarcinoma (LUAD). Methods: We analyzed RNA and protein databases to assess the expression levels of cytochrome C oxidase 5B (COX5B) in LUAD. Several computational algorithms were employed to investigate the relationship between COX5B and immune infiltration in LUAD. To further elucidate the role of COX5B in LUAD, we utilized… More > Graphic Abstract

Xu Guo¹, Yanan Yu², Xiaolin Ma³, Yuanjie Cai^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069274 - 30 December 2025

Abstract Background: Long non-coding RNAs (lncRNAs) act as epigenetic regulators for tumor hallmarks. This investigation sought to probe the carcinogenic trait of PAN3-AS1 across pan-cancer comprehensively. Methods: We studied the diagnostic and prognostic features and the immune landscape of PAN3-AS1 across pan-cancer by bioinformatics approaches. The hierarchical regulatory networks governing PAN3-AS1 expression in colon cancer were explored via chromatin immunoprecipitation, luciferase activity assays, and RNA immunoprecipitation, etc. We screened drugs sensitive to WAP four-disulfide core domain 13 (WFDC13) by virtual screening and molecular docking. Results: Single-cell transcriptomics demonstrated that a variety of immune populations abnormally expressed PAN3-AS1… More >

M. N. Abd-Al Ameer, Iman S. Kareem, Ali A. Ismaeel^*

Energy Engineering, Vol.123, No.1, 2026, DOI:10.32604/ee.2025.073437 - 27 December 2025

Abstract Electrical and electronic devices face significant challenges in heat management due to their compact size and high heat flux, which negatively impact performance and reliability. Conventional cooling methods, such as forced air cooling, often struggle to transfer heat efficiently. In contrast, thermoelectric coolers (TECs) provide an innovative active cooling solution to meet growing thermal management demands. In this research, a refrigerant based on mono ethylene glycol and distilled water was used instead of using gases, in addition to using thermoelectric cooling units instead of using a compressor in traditional refrigeration systems. This study evaluates the… More > Graphic Abstract

Bo Zhu^1,#, Enzhi Dong^1,#, Zhonghua Cheng^1,*, Xianbiao Zhan², Kexin Jiang¹, Rongcai Wang ³

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-26, 2026, DOI:10.32604/cmc.2025.069194 - 10 November 2025

Abstract With the increasing complexity of industrial automation, planetary gearboxes play a vital role in large-scale equipment transmission systems, directly impacting operational efficiency and safety. Traditional maintenance strategies often struggle to accurately predict the degradation process of equipment, leading to excessive maintenance costs or potential failure risks. However, existing prediction methods based on statistical models are difficult to adapt to nonlinear degradation processes. To address these challenges, this study proposes a novel condition-based maintenance framework for planetary gearboxes. A comprehensive full-lifecycle degradation experiment was conducted to collect raw vibration signals, which were then processed using a… More >

Tianen Liu^1,2, Kun Dai^1,2, Shiju Ren^1,2, Chuanxiang Zhang^1,2, Xiaoling Tang^3,*, Jinghong Hu^3,*, Yidong Cai³, Jun Lu³

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.12, pp. 2981-2995, 2025, DOI:10.32604/fdmp.2025.073859 - 31 December 2025

Abstract Many mature onshore oilfields have entered a high-water-cut stage, with reservoir recovery approaching economic limits. Converting these depleted or nearly depleted reservoirs into underground gas storage (UGS) facilities offers an efficient way to leverage their substantial storage potential. During cyclic gas injection and withdrawal, however, the reservoir experiences complex three-phase flow and repeated stress fluctuations, which can induce rock fatigue, inelastic deformation, and ultimately sand production. This study uses controlled physical experiments to simulate sand production in reservoir rocks subjected to alternating gas injection and production under three-phase conditions. After preparing oil-water-saturated cores through waterflooding,… More >

Wei Chen^*, Yuanteng Zhao, Yue Liang

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.12, pp. 3033-3053, 2025, DOI:10.32604/fdmp.2025.073778 - 31 December 2025

Abstract In deep underground engineering, geological disposal of nuclear waste, and geothermal development, the granite–mortar interface represents a critical weak zone that strongly influences sealing performance under high-temperature conditions. While previous studies have primarily focused on single materials, the dynamic evolution of interface permeability under thermal loading remains insufficiently understood. In this study, time-resolved gas permeability measurements under thermal cycling (20°C → 150°C → 20°C) were conducted, complemented by multi-scale microstructural characterization, to investigate the nonlinear evolution of permeability. Experimental results indicate that interface permeability at room temperature is approximately one order of magnitude higher than… More >

Zhengqiang Peng^1,*, Rendong Feng¹, Fang Han¹, Jing Guo¹, Shen Chi¹, Wenao Huang¹, Jie Luo²

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.12, pp. 2945-2961, 2025, DOI:10.32604/fdmp.2025.073281 - 31 December 2025

Abstract Jet pumps often suffer from efficiency losses due to the intense mixing of power and suction fluids, which leads to significant kinetic energy dissipation. Enhancing the efficiency of such pumps requires careful optimization of their structural parameters. In this study, a computational fluid dynamics (CFD) model of a hydraulic jet sand-flushing pump is developed to investigate the effects of throat-to-nozzle distance, area ratio, and throat length on the pump’s sand-carrying performance. An orthogonal experimental design is employed to optimize the structural parameters, while the influence of sand characteristics on pumping performance is systematically evaluated. Complementary… More >

Mengjie Wang¹, Jingfa Li^2,*, Bo Yu², Nianrong Wang³, Xiaofeng Wang³, Tao Hu⁴

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.12, pp. 3055-3072, 2025, DOI:10.32604/fdmp.2025.071675 - 31 December 2025

Abstract The adaptation of existing natural gas pipelines for hydrogen transportation has attracted increasing attention in recent years. Yet, whether hydrogen and natural gas stratify under static conditions remains a subject of debate, and experimental evidence is still limited. This study presents an experimental investigation of the concentration distribution of hydrogen–natural gas mixtures under static conditions. Hydrogen concentration was measured using a KTL-2000M-H hydrogen analyzer, with a measurement range of 0–30% (by volume), an accuracy of 1% full scale (FS), and a resolution of 0.01%. Experiments were conducted in a 300 cm riser, filled with uniformly… More >

Shuo Wang^1,2,*, Huiming Wang^1,2, Ying Zhang^1,2, Zhiqiang Zhang^1,3, Li Jia^1,2

Frontiers in Heat and Mass Transfer, Vol.23, No.6, pp. 1721-1740, 2025, DOI:10.32604/fhmt.2025.073226 - 31 December 2025

Abstract This experimental investigation was conducted on the flow boiling performance of refrigerant R134a in two types of parallel microchannels: sintered porous microchannels (PP-MCs) and smooth parallel microchannels (SP-MCs). The tests were performed under controlled conditions including an inlet subcooling of 5 ± 0.2°C, saturation temperature of 33°C, mass fluxes of 346 and 485 kg/m²·s, and a range of heat fluxes. Key findings reveal that the sintered porous microstructure significantly enhances bubble nucleation, reducing the wall superheat required for the onset of nucleate boiling (ONB) to only 0.13°C compared to 2.2°C in smooth channels. The porous structure… More >

Md Salah Uddin^*

Journal of Polymer Materials, Vol.42, No.4, pp. 1051-1073, 2025, DOI:10.32604/jpm.2025.070688 - 26 December 2025

Abstract Carbon fiber-reinforced composites (CFRCs) have a wide range of applications in the aerospace, automotive, and energy sectors. A higher specific strength-to-weight ratio is desired in high-performance applications. The failure mechanism of CFRCs involves multiscale phenomena, such as failure that can occur at the matrix, fibers, interface, layers, lamina, and laminates. When an impactor hits the CFRCs, the design involves analyzing each of these stages to prevent failure and optimize the properties of CFRCs under various loading conditions. A numerical model was employed to predict the fracture toughness of CFRCs with varying weight fractions and orientations.… More >