Lv Ling^1,#, Minying Lu^2,#, Ling Ye³, Yuanhang Chen², Sheng Lin², Jun Yang², Yu Rong^2,*, Guixiong Wu^4,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069889 - 30 December 2025

Abstract Background: A significant proportion of patients still cannot benefit from existing targeted therapies and immunotherapies, making the search for new treatment strategies extremely urgent. In this study, we combined integrate public data analysis with experimental validation to identify novel prognostic biomarkers and therapeutic targets for lung adenocarcinoma (LUAD). Methods: We analyzed RNA and protein databases to assess the expression levels of cytochrome C oxidase 5B (COX5B) in LUAD. Several computational algorithms were employed to investigate the relationship between COX5B and immune infiltration in LUAD. To further elucidate the role of COX5B in LUAD, we utilized… More > Graphic Abstract

Yuliang Zhang^1,2,*, Zezhou Yang¹, Lianghuai Tong^3,*, Yanjuan Zhao⁴, Xiaoqi Jia⁵, Anda Han⁶

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.4, pp. 891-938, 2025, DOI:10.32604/fdmp.2024.059903 - 06 May 2025

Abstract This paper investigates the start-up and shutdown phases of a five-bladed closed-impeller centrifugal pump through experimental analysis, capturing the temporal evolution of its hydraulic performances. The study also predicts the transient characteristics of the pump under non-rated operating conditions to assess the accuracy of various machine learning methods in forecasting its instantaneous performance. Results indicate that the pump’s transient behavior in power-frequency mode markedly differs from that in frequency-conversion mode. Specifically, the power-frequency mode achieves steady-state values faster and exhibits smaller fluctuations before stabilization compared to the other mode. During the start-up phase, as… More >

Djordje Spasojević^1,*, Sanja Janićević², Svetislav Mijatović¹, Bosiljka Tadić^3,4

CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.2, pp. 1021-1107, 2025, DOI:10.32604/cmes.2024.057884 - 27 January 2025

Abstract Disordered ferromagnets with a domain structure that exhibit a hysteresis loop when driven by the external magnetic field are essential materials for modern technological applications. Therefore, the understanding and potential for controlling the hysteresis phenomenon in these materials, especially concerning the disorder-induced critical behavior on the hysteresis loop, have attracted significant experimental, theoretical, and numerical research efforts. We review the challenges of the numerical modeling of physical phenomena behind the hysteresis loop critical behavior in disordered ferromagnetic systems related to the non-equilibrium stochastic dynamics of domain walls driven by external fields. Specifically, using the extended… More >

Yi Xuan Chew, Siti Fatimah Abdul Razak^*, Sumendra Yogarayan, Sharifah Noor Masidayu Sayed Ismail

CMC-Computers, Materials & Continua, Vol.81, No.3, pp. 4397-4417, 2024, DOI:10.32604/cmc.2024.056367 - 19 December 2024

Abstract In the modern world, the increasing prevalence of driving poses a risk to road safety and necessitates the development and implementation of effective monitoring systems. This study aims to enhance road safety by proposing a dual-modal solution for detecting driver drowsiness, which combines heart rate monitoring and face recognition technologies. The research objectives include developing a non-contact method for detecting driver drowsiness, training and assessing the proposed system using pre-trained machine learning models, and implementing a real-time alert feature to trigger warnings when drowsiness is detected. Deep learning models based on convolutional neural networks (CNNs),… More >

Zhenyu Zhu¹, Ping Zhou¹, Xingbang Wan¹, Zhuo Chen^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.29, No.2, pp. 1-4, 2024, DOI:10.32604/icces.2024.011777

Abstract 1 General introduction
The flash smelting is one of the dominant technologies for copper matte production. To meet the increasing demand, the production capability of flash smelting furnace has been increased several times. However, under current conditions, the segregation of concentrate particles becomes an escalating issue, impacting production efficiency and safety [1]. The DEM modelling is a powerful tool for investigating particle behaviors such as contact and collision, but the lack of accurate microscopic properties of copper concentrate particles makes it challenging to conduct reliable DEM simulations [2]. To address this gap, this study employs both… More >

Xiao Sun¹, Huifan Huang¹, Yuliang Zhang², Lianghuai Tong^3,*, Xiaowei Xu², Xiaoqi Jia⁴, Litao Ou⁵

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.10, pp. 2251-2264, 2024, DOI:10.32604/fdmp.2024.050997 - 23 September 2024

Abstract In order to obtain the transient characteristics of a low-speed centrifugal pump during the start-up and shutdown stages, dedicated experimental tests were conducted with eight different valve opening conditions. The Pearson correlation coefficient was used to reveal the linear correlation between variables. According to the results, the stable rotational speed decreases with increasing valve opening (rotational speed decreases from approximately 1472 to 1453 r/min), while the stable shaft power exhibits an increasing trend (shaft power increases from approximately 0.242 to 0.390 kW). The stable time and zeroing time of each parameter during start-up and shutdown More >

Pirapat Arunyanart, Nithitorn Kongkaew, Supattarachai Sudsawat^*

CMC-Computers, Materials & Continua, Vol.80, No.2, pp. 3379-3403, 2024, DOI:10.32604/cmc.2024.054337 - 15 August 2024

Abstract This research introduces a novel approach to enhancing bucket elevator design and operation through the integration of discrete element method (DEM) simulation, design of experiments (DOE), and metaheuristic optimization algorithms. Specifically, the study employs the firefly algorithm (FA), a metaheuristic optimization technique, to optimize bucket elevator parameters for maximizing transport mass and mass flow rate discharge of granular materials under specified working conditions. The experimental methodology involves several key steps: screening experiments to identify significant factors affecting bucket elevator operation, central composite design (CCD) experiments to further explore these factors, and response surface methodology (RSM)… More >

Kenta Hashimoto¹, Guohui Sun¹, Yasushi Koito^2,*

Frontiers in Heat and Mass Transfer, Vol.22, No.3, pp. 687-702, 2024, DOI:10.32604/fhmt.2024.052928 - 11 July 2024

Abstract Centered or striped wick structures have been used to develop ultrathin heat pipes. Differing from traditional heat pipes, the centered or striped wick structures leave noncontact container surfaces with the wick structure. In this study, experiments and numerical analyses were conducted to investigate the influence of these noncontact surfaces. In the experiments, a strip-shaped wick structure was placed vertically, the top was sandwiched between wider rods and the bottom was immersed in a working fluid. The rod width was greater than the wick width; thus, noncontact surfaces were left between the rod and the wick… More >

Shi Dai¹, Yanping Lian^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.25, No.3, pp. 1-1, 2023, DOI:10.32604/icces.2023.010175

Abstract In recent years, metal additive manufacturing (AM) has gained increasing attention from various industries. However, there are few studies on the thermal deformation behavior of additively manufactured metallic components, which is vital to pushing its applications’ boundary. In this work, we first experimentally investigate the mechanical behavior of AlSi10Mg produced by laser powder bed fusion under different temperatures and strain rates. A crystal plasticity finite element model is adopted to provide insights into the intrinsic deformation mechanisms. The model is validated by comparing it with the flow behaviors and dislocation evolutions observed in experiments at More >

Xuelian Zhang¹, Junjie Liu^1,*, Jian Li², Zhihong Liang¹, Han Jiang¹, Guozheng Kang¹, Qianhua Kan^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.25, No.3, pp. 1-1, 2023, DOI:10.32604/icces.2023.010142

Abstract The last decades have witnessed the real and huge potential applications of hydrogels in various areas, including biomedicine, soft robotics, and flexible electronics. The fatigue of hydrogels challenges their reliability and longevity in service, but the related works are not sufficient. In this work, stress-controlled cyclic fatigue tests of a double-network tough hydrogel, consisting of polyacrylamide and alginate polymer networks, under pure shear deformation are investigated. The effects of peak stress, loading rate, peak stress holding time, and environmental relative humidity on the fatigue of the double-network tough hydrogel are considered. The results show that… More >