Cristiane Dos Santos VERGILIO, Edésio José Tenório De MELO^*

BIOCELL, Vol.37, No.2, pp. 45-54, 2013, DOI:10.32604/biocell.2013.37.045

Abstract Cadmium (Cd) induces several effects in different tissues, but our knowledge of the toxic effects on organelles is insufficient. To observe the progression of Cd effects on organelle structure and function, HuH-7 cells (human hepatic carcinoma cell line) were exposed to CdCl2 in increasing concentrations (1 μM – 20 μM) and exposure times (2 h – 24 h). During Cd treatment, the cells exhibited a progressive decrease in viability that was both time- and dose-dependent. Cd treated cells displayed progressive morphological changes that included cytoplasm retraction and nuclear condensation preceding a total loss of cell adhesion. Treatment with 10 μM… More >

B.C. Heng*, K.J. Vinoth*, K. Lu*, X. Deng*, Z. Ge*, B.H. Bay**, T. Cao*

BIOCELL, Vol.31, No.3, pp. 405-410, 2007, DOI:10.32604/biocell.2007.31.405

Abstract We investigated the effects of prolonged heat shock treatment on human embryonic stem cell (hESC) viability. The hESC viability steadily declined with longer exposure to heat shock treatment (43ºC). After 4 h of exposure to heat shock at 43ºC, only 56.2 ± 1.5% of cells were viable. Viability subsequently declined to 37.0 ± 3.3% and 3.5 ± 0.7% after 8 h and 16 h, respectively of heat shock treatment at 43ºC. Transmission electron micrographs showed that the morphology of the dead/dying cells after heat shock treatment was characteristic of cellular necrosis with an uncondensed chromatin and a non-intact plasma membrane.… More >

Yufan Huang¹, Pei Niu², Li Li², Yunlong Huo^3,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 47-47, 2019, DOI:10.32604/mcb.2019.05726

Abstract We aimed to illustrate the association between short-term exposure PM0.1 and heart failure in myocardial infarction (MI) mice. Six-week-old ICR mice were divided into three groups randomly: sham group, MI group and MI exposure group, 12 mice in each group. LAD ligation operation was performed in MI group and MI exposure group. After postoperative two weeks MI exposure mice were put into ventilation chamber which filled with 500 ug/m³ PM_0.1 for 6 hours per day, while MI group mice and sham group mice were cultivated in normal environment. After exposure 8 weeks, we use Vevo 2100 machine to acquire heart… More >

Jimena P. CABILLA, Sonia A. RONCHETTI, Beatriz H. DUVILANSKI^*

BIOCELL, Vol.40, No.1, pp. 15-18, 2016, DOI:10.32604/biocell.2016.40.015

Abstract Environmental contamination with some metalloids and heavy metals (M/HM) raises concern due to well known adverse effects on health. Among these pollutants, chromium VI (Cr VI), cadmium (Cd) and arsenic (As) are frequently present as a result of natural sources or due to industrial activities. They are able to easily enter the organism and negatively affect many organs and systems. In vivo (exposure to Cr VI, Cd or As through drinking water) and in vitro experiments (primary pituitary cell cultures) were performed in male Wistar rats to address their actions on hypothalamus-pituitary axis. All the M/HM accumulated in hypothalamus and… More >

Ramesa Shafi BHAT¹, Amina El GEZEERY², Abir Ben BACHAN¹, Mona Awad ALONAZI¹, Leena Saleh ALSUHAIBANI¹, Afaf El-ANSARY^3,4

BIOCELL, Vol.43, No.2, pp. 65-71, 2019, DOI:10.32604/biocell.2019.07012

Abstract Fluoride is a key ingredient of many psychiatric drugs like fluoxetine (Prozac^®, Fluoxetine^®). Pregnant women frequently use this drug as they suffer from depression and anxiety disorders during this period. Fluoxetine is able to reach the fetus through the placenta and passes to the newborn through milk. In the present study, female Wistar rats were treated with 5, 10, and 20 mg/L fluoxetine (containing 94% fluorides) from pregnancy day 10 to day 20. After delivery, the levels of the enzymatic antioxidants in the brain of their offspring at postnatal day 2 were measured. The results showed that, in all fluoxetine… More >

A. P. S. Selvadurai¹, Q. Yu²

CMES-Computer Modeling in Engineering & Sciences, Vol.9, No.1, pp. 85-110, 2005, DOI:10.3970/cmes.2005.009.085

Abstract A characteristic feature of a polymeric material such as PVC is its hyperelasticity or the ability to experience large strains prior to failure. The exposure of PVC to chemicals such as acetone and ethanol results in embrittlement or the loss of the hyperelasticity property. In this paper, we examine the mechanical behaviour of a PVC membrane that has been exposed to ethanol. Due to leaching of the plasticizer, the constitutive response of the PVC changes from a hyperelastic material to a hardened material that displays dominant yield behaviour and particularly one that is capable of experiencing post-yield large strains and… More >

G. Geethanjali^∗, C. Sujatha^†

Molecular & Cellular Biomechanics, Vol.10, No.4, pp. 303-317, 2013, DOI:10.3970/mcb.2013.010.303

Abstract This paper reports a study on the biomechanical response of a human hand-arm model to random vibrations of the steering wheel of a tractor. An anatomically accurate bone-only hand-arm model from TurboSquidTM was used to obtain a finite element (FE) model to understand the Hand-arm vibration syndrome (HAVS), which is a neurological and vascular disorder caused by exposure of the human hand-arm to prolonged vibrations. Modal analysis has been done to find out the first few natural frequencies and mode shapes of the system. Coupling of degrees of freedom (DOF) had to be done in the FE idealization to do… More >

Hana Chang^*, Melissa L. Knothe Tate^∗,†,‡

Molecular & Cellular Biomechanics, Vol.8, No.4, pp. 297-318, 2011, DOI:10.3970/mcb.2011.008.297

Abstract In the preceding study (Part A), we showed that prescribed seeding conditions as well as seeding density can be used to subject multipotent stem cells (MSCs) to volume changing stresses and that changes in volume of the cell are associated with changes in shape, but not volume, of the cell nucleus. In the current study, we aim to control the mechanical milieu of live cells using these prescribed seeding conditions concomitant to delivery of shape changing stresses via fluid flow, while observing adaptation of the cytoskeleton, a major cellular transducer that modulates cell shape, stiffness and remodeling. We hypothesize that… More >

S. Freire¹, D. Ehrlich¹, S. Ferri¹

CMES-Computer Modeling in Engineering & Sciences, Vol.109-110, No.2, pp. 159-182, 2015, DOI:10.3970/cmes.2015.109.159

Abstract Media and specialized scientific literature are often addressing the “increasing impact and ensuing damages due to natural hazards”. It is frequently argued that a rising frequency and intensity of hazards is responsible for the increase in losses. The role of increasing population exposure due to phenomenal population growth, or urbanization as a driver of risk is still insufficiently addressed. We investigate spatio-temporal changes in population exposure to seismic hazard and their role on impacts from earthquakes in the XX century. Spatial analysis is used to study historical population distributions in relation to seismic intensity, at the global and continental levels.… More >