Yuanyuan Yang^1,2,#, Peipei Zhao^1,2,#, Hepu Chen^1,3, Yixuan Tu⁴, Yujia Zhou², Xu Liu³, Lyly Sreang³, Zhigang Zhou^3,5,*, Jian Tu^1,2,*

Oncology Research, Vol.33, No.11, pp. 3247-3268, 2025, DOI:10.32604/or.2025.066440 - 22 October 2025

Abstract Hepatocellular carcinoma (HCC) is characterized by its highly invasive and metastatic potential, as well as a propensity for recurrence, contributing to treatment failure and increased mortality. Under physiological conditions, the liver maintains a balance in lipid biosynthesis, degradation, storage, and transport. HCC exhibits dysregulated lipid metabolism, driving tumor progression and therapeutic resistance. This review aims to elucidate the roles of fatty acid, sphingolipid, and cholesterol metabolism in HCC pathogenesis and explore emerging therapeutic strategies targeting these pathways. Key findings demonstrate that upregulated enzymes like fatty acid synthase (FASN), acetyl-CoA carboxylase (ACC), enhance de novo lipogenesis and… More >

Juan Francisco Zamora Natera^1,*, Mario Felipe González González¹, Javier Vioque², Julio Girón-Calle², Manuel Alaiz²

Phyton-International Journal of Experimental Botany, Vol.94, No.5, pp. 1533-1544, 2025, DOI:10.32604/phyton.2025.064966 - 29 May 2025

Abstract Jarilla caudata Standl. (Caricaceae) is a wild herbaceous plant native to Mexico recognized for its edible fruits. It is considered to be the closest taxonomically species to Carica papaya L. (Caricaceae), whose seeds have good nutritional and functional properties. This study analyzes and compares the seed chemical compositions of J. caudata and C. papaya to study the nutritional and functional potential of J. caudata seeds. The analysis of the proximate composition was based on standard methods. High-performance liquid chromatography was used to determine the free amino acid profile, gas chromatography to quantify the fatty acid content, and inductively coupled plasma–optical… More > Graphic Abstract

Prabu Satria Sejati^1,2, Adrien Magne¹, Luke Froment¹, Jennifer Afrim¹, Alexandre Maenhaut³, Julie Maillet³, Firmin Obounou Akong^1,*, Frédéric Fradet³, Philippe Gérardin^1,*

Journal of Renewable Materials, Vol.13, No.3, pp. 539-552, 2025, DOI:10.32604/jrm.2024.056813 - 20 March 2025

Abstract Bio-based thermoplastic film from flax fiber and fatty acid (FA) was obtained using trifluoroacetic anhydride (TFAA) as an impelling agent. Different quantities of TFAA/FA, size of flax fiber, and fatty acids were applied to investigate chemical structure in relation to the mechanical properties. Decreasing the quantity of TFAA/FA by almost half from 1:4 to 1:2.5 (flax to TFAA/FA) only reduces by 22% the weight percent gain (WPG) and ester content and reducing flax fiber size slightly increases the WPG and ester content. All the treatments showed significant chemical structure modification, observed by FTIR and… More > Graphic Abstract

Aiga Ivdre^*, Ralfs Pomilovskis, Arnis Abolins

Journal of Renewable Materials, Vol.13, No.2, pp. 349-361, 2025, DOI:10.32604/jrm.2024.056820 - 20 February 2025

Abstract Studies on the use of renewable materials for various applications, including polymers, have gained momentum due to global climate change and the push towards a circular economy. In this study, polymer resins were developed through Michael 1,4-addition. The precursors were synthesized from tall oil-based acetoacetates derived from epoxidized tall oil fatty acids or their methyl esters. Two different epoxidation methods were employed: enzymatic epoxidation of tall oil fatty acids and ion-exchange resin epoxidation of tall oil fatty acid methyl esters. Following oxirane opening and transesterification with trimethylolpropane, further esterification or transesterification was carried out to… More >

Dongxue Su¹, Jiarui Zheng¹, Yuwei Yi¹, Shuyuan Zhang¹, Luxin Feng¹, Danzeng Quzhen², De Qiong³, Weiwei Zhang¹, Qijian Wang¹, Feng Xu^1,*

Phyton-International Journal of Experimental Botany, Vol.93, No.9, pp. 2317-2337, 2024, DOI:10.32604/phyton.2024.055350 - 30 September 2024

Abstract The multifaceted roles of MYB transcriptional regulators are pivotal in orchestrating the complex processes of secondary metabolism, stress tolerance mechanisms, and life cycle progression and development. This study extensively examined the JrMYB genes using whole genome and transcriptomic data, focusing on identifying putative MYB genes associated with fatty acid metabolism. 126 MYB genes were identified within the walnut genome, characterized by hydrophilic proteins spanning lengths ranging from 78 to 1890 base pairs. Analysis of cis-acting elements within the promoter regions of MYB genes revealed many elements linked to cell development, environmental stress, and phytohormones. Transcriptomic data was utilized… More > Graphic Abstract

YUANYUAN LIAO^1,2,3, XINSI LI^2,3, QIAN LI^2,3, YIZHONG WANG⁴, XIUJUN TAN^1,2,3, TING GONG^2,3,5,*

BIOCELL, Vol.48, No.6, pp. 873-887, 2024, DOI:10.32604/biocell.2024.050324 - 10 June 2024

Abstract As we are facing an aging society, anti-aging strategies have been pursued to reduce the negative impacts of aging and increase the health span of human beings. Gut microbiota has become a key factor in the anti-aging process. Modulation of gut microbiota by fecal microbiota transplantation (FMT) to prevent frailty and unhealthy aging has been a hot topic of research. This narrative review summarizes the benefits of FMT for health span and lifespan, brains, eyes, productive systems, bones, and others. The mechanisms of FMT in improving healthy aging are discussed. The increased beneficial bacteria and More >

JIECHUAN QIU¹, TIANMIN YANG¹, YANNING SUN², KAI SUN², YINGKUN XU³, QINGHUA XIA^1,*

Oncology Research, Vol.32, No.3, pp. 545-561, 2024, DOI:10.32604/or.2023.030462 - 06 February 2024

Abstract This research aims to identify the key fatty acid beta-oxidation (FAO) genes that are altered in kidney renal clear cell carcinoma (KIRC) and to analyze the role of these genes in KIRC. The Gene Expression Omnibus (GEO) and FAO datasets were used to identify these key genes. Wilcoxon rank sum test was used to assess the levels of acyl-CoA dehydrogenase medium chain (ACADM) between KIRC and non-cancer samples. The logistic regression and Wilcoxon rank sum test were used to explore the association between ACADM and clinical features. The diagnostic performance of ACADM for KIRC was… More >

HENG ZHANG^1,#, WENJING CHENG^2,#, HAIBO ZHAO², WEIDONG CHEN², QIUJIE ZHANG^2,*, QING-QING YU^2,*

Oncology Research, Vol.32, No.2, pp. 297-308, 2024, DOI:10.32604/or.2023.043138 - 28 December 2023

Abstract Background: Colorectal cancer (CRC) belongs to the class of significantly malignant tumors found in humans. Recently, dysregulated fatty acid metabolism (FAM) has been a topic of attention due to its modulation in cancer, specifically CRC. However, the regulatory FAM pathways in CRC require comprehensive elucidation. Methods: The clinical and gene expression data of 175 fatty acid metabolic genes (FAMGs) linked with colon adenocarcinoma (COAD) and normal cornerstone genes were gathered through The Cancer Genome Atlas (TCGA)-COAD corroborating with the Molecular Signature Database v7.2 (MSigDB). Initially, crucial prognostic genes were selected by uni- and multi-variate Cox… More >

PAVITHRA SUBRAMANI^1,2, RAUNAK KUMAR DAS^1,*

BIOCELL, Vol.47, No.10, pp. 2195-2205, 2023, DOI:10.32604/biocell.2023.030383 - 08 November 2023

Abstract Solar ultraviolet B (UVB) radiation is a major skin cancer-causing agent. Initiation, promotion, and progression are the diverse phases of UVB-induced carcinogenesis. Exposure to UVB causes abnormalities in a series of biochemical and molecular pathways: thymine dimer formation, DNA damage, oxidative stress, inflammatory responses, and altered cell signaling, eventually resulting in tumor formation. The increased skin cancer rates urge researchers to develop more efficient drugs, but synthetic chemotherapeutic drugs have more contrary effects and drug resistance issues, which have been reported recently. The current review focuses on the relationship between microbes and cancer. Human skin… More > Graphic Abstract

SHENGJIE SONG, ZHIZHOU SHI^*

BIOCELL, Vol.47, No.10, pp. 2207-2215, 2023, DOI:10.32604/biocell.2023.027677 - 08 November 2023

Abstract Metabolic reprogramming frequently occurs in the majority of cancers, wherein fatty acid oxidation (FAO) is usually induced and serves as a compensatory mechanism to improve energy consumption. Carnitine palmitoyltransferase 1A (CPT1A) is the rate-limiting enzyme for FAO and is widely involved in tumor growth, metastasis, and chemo-/radio-resistance. This review summarizes the most recent advances in understanding the oncogenic roles and mechanisms of CPT1A in tumorigenesis, including in proliferation and tumor growth, invasion and metastasis, and the tumor microenvironment. Importantly, CPT1A has been shown to be a biomarker for diagnosis and prognosis prediction and proved to More > Graphic Abstract