JIECHUAN QIU¹, TIANMIN YANG¹, YANNING SUN², KAI SUN², YINGKUN XU³, QINGHUA XIA^1,*

Oncology Research, Vol.32, No.3, pp. 545-561, 2024, DOI:10.32604/or.2023.030462

Abstract This research aims to identify the key fatty acid beta-oxidation (FAO) genes that are altered in kidney renal clear cell carcinoma (KIRC) and to analyze the role of these genes in KIRC. The Gene Expression Omnibus (GEO) and FAO datasets were used to identify these key genes. Wilcoxon rank sum test was used to assess the levels of acyl-CoA dehydrogenase medium chain (ACADM) between KIRC and non-cancer samples. The logistic regression and Wilcoxon rank sum test were used to explore the association between ACADM and clinical features. The diagnostic performance of ACADM for KIRC was assessed using a diagnostic receiver… More >

HENG ZHANG^1,#, WENJING CHENG^2,#, HAIBO ZHAO², WEIDONG CHEN², QIUJIE ZHANG^2,*, QING-QING YU^2,*

Oncology Research, Vol.32, No.2, pp. 297-308, 2024, DOI:10.32604/or.2023.043138

Abstract Background: Colorectal cancer (CRC) belongs to the class of significantly malignant tumors found in humans. Recently, dysregulated fatty acid metabolism (FAM) has been a topic of attention due to its modulation in cancer, specifically CRC. However, the regulatory FAM pathways in CRC require comprehensive elucidation. Methods: The clinical and gene expression data of 175 fatty acid metabolic genes (FAMGs) linked with colon adenocarcinoma (COAD) and normal cornerstone genes were gathered through The Cancer Genome Atlas (TCGA)-COAD corroborating with the Molecular Signature Database v7.2 (MSigDB). Initially, crucial prognostic genes were selected by uni- and multi-variate Cox proportional regression analyses; then, depending… More >

PAVITHRA SUBRAMANI^1,2, RAUNAK KUMAR DAS^1,*

BIOCELL, Vol.47, No.10, pp. 2195-2205, 2023, DOI:10.32604/biocell.2023.030383

Abstract Solar ultraviolet B (UVB) radiation is a major skin cancer-causing agent. Initiation, promotion, and progression are the diverse phases of UVB-induced carcinogenesis. Exposure to UVB causes abnormalities in a series of biochemical and molecular pathways: thymine dimer formation, DNA damage, oxidative stress, inflammatory responses, and altered cell signaling, eventually resulting in tumor formation. The increased skin cancer rates urge researchers to develop more efficient drugs, but synthetic chemotherapeutic drugs have more contrary effects and drug resistance issues, which have been reported recently. The current review focuses on the relationship between microbes and cancer. Human skin acts as a barrier against… More > Graphic Abstract

SHENGJIE SONG, ZHIZHOU SHI^*

BIOCELL, Vol.47, No.10, pp. 2207-2215, 2023, DOI:10.32604/biocell.2023.027677

Abstract Metabolic reprogramming frequently occurs in the majority of cancers, wherein fatty acid oxidation (FAO) is usually induced and serves as a compensatory mechanism to improve energy consumption. Carnitine palmitoyltransferase 1A (CPT1A) is the rate-limiting enzyme for FAO and is widely involved in tumor growth, metastasis, and chemo-/radio-resistance. This review summarizes the most recent advances in understanding the oncogenic roles and mechanisms of CPT1A in tumorigenesis, including in proliferation and tumor growth, invasion and metastasis, and the tumor microenvironment. Importantly, CPT1A has been shown to be a biomarker for diagnosis and prognosis prediction and proved to be a candidate therapeutic target,… More > Graphic Abstract

Elham Azadeh¹, Ummi Hani Abdullah^2,3, Christine Gerardin^1,*, Antonio Pizzi^1,*, Philippe Gerardin¹, Cesar Segovia⁴

Journal of Renewable Materials, Vol.11, No.10, pp. 3625-3645, 2023, DOI:10.32604/jrm.2023.030373

Abstract Water repellant, flexible biofoams using tannin esterified with various fatty acid chains, namely lauric, palmitic and oleic acids, by reaction with lauryl chloride, palmitoyl chloride, and oleyl chloride were developed and their characteristics compared with the equivalently esterified rigid biofoams. Glycerol, while initially added to control the reaction temperature, was used as a plasticizer yielding flexible biofoams presenting the same water repellant character that the equivalent rigid foams. Acetaldehyde was used as the cross-linking agent instead of formaldehyde, as it showed a better performance with the esterified tannin. The compression results showed a significant decrease of the Modulus of Elasticity… More >

Xiao Han, Songnan Yang, Xueying Li, Qiulin Wu, Yongyi Xing, Jun Zhang^*, Fenglou Ling^*

Phyton-International Journal of Experimental Botany, Vol.92, No.9, pp. 2577-2589, 2023, DOI:10.32604/phyton.2023.029440

Abstract Peanut, with high oil content, has been a major oil and food crop globally. The compositions of the fatty acids are the common factors in determining the oil quality. In the present study, an F2 segregated population with 140 individuals derived from the cross of Weihua8 (a cultivar) and 12L49 (a line with high oleic acid concentration) was used to construct a genetic map and conduct QTL mapping analysis. A total of 103 polymorphic SSR primers were utilized for genotyping the RILs and finally generating the SSR loci. Within the 103 SSR loci, a genetic linkage map, covering a total… More >

MIZUNA YANO¹, KOTA HIROI¹, TETSUYA YUASA¹, KENJI INOUE¹, OSAMU YAMAMOTO¹, TAKAO NAKAMURA², DAISUKE SATO¹, ZHONGGANG FENG^1,*

BIOCELL, Vol.47, No.5, pp. 1095-1106, 2023, DOI:10.32604/biocell.2023.028186

Abstract Background: Human heart changes its energetic substrates from lactate and glucose to fatty acids during the neonatal period. Noticing the lack of fatty acids in media for the culture of cardiomyocytes derived from human pluripotent stem cells (hiPS-CM), researchers have supplemented mixtures of fatty acids to hiPS-CM and reported the enhancement in the maturation of hiPS-CM. In our previous studies, we separately supplemented two polyunsaturated fatty acids (PUFAs), docosahexaenoic acid (DHA) or arachidonic acid (AA), to rat fetal cardiomyocytes and found that the supplementations upregulated the expressions of mRNAs for cardiomyocyte differentiation, fatty acid metabolism, and cellular adhesion. The enhancement… More >

Ziyang Feng^1,#, Xinqi Cheng^2,#, Tianwen Wang³, Yongchao Han¹, Haihong Chen¹, Xinyu Zhang¹, Jie Sun¹, Wei Zhang^1,*, Feng Liu^1,*

Phyton-International Journal of Experimental Botany, Vol.92, No.5, pp. 1633-1647, 2023, DOI:10.32604/phyton.2023.027542

Abstract Fatty Acyl-ACP thioesterase (FAT) is a key enzyme controlling oil biosynthesis in plant seeds. FATs can be divided into two subfamilies, FATA and FATB according to their amino acid sequences and substrate specificity. The Upland cotton genome contains 20 GhFAT genes, amongst which 6 genes were of the GhFATA subfamily and 14 of the GhFATB subfamily. The 20 GhFAT genes are unevenly distributed on 14 chromosomes. The GhFATA genes have 5 or 7 exons and the GhFATB genes have 6 or 7 exons. All GhFAT proteins have the conserved Acyl-ACP_TE domain and PLN02370 super family, the typical characteristics of plant… More >

Ruyu Yan^1,2,3,4, Jian Fang^1,*, Xiaohua Yang^2,3,4,5,6, Na Yao^2,3,4,5,6, Mei Li^2,3,4,5,6, Yuan Nie^2,3,4,5,6, Tianxiang Deng^2,3,4,5,6, Haiyang Ding^2,3,4,5,6, Lina Xu^2,3,4,5,6, Shouhai Li^2,3,4,5,6,*

Journal of Renewable Materials, Vol.11, No.4, pp. 1937-1950, 2023, DOI:10.32604/jrm.2023.025126

Abstract Ethyl cellulose (EC), an important biomass-based material, has excellent film-forming properties. Nevertheless, the high interchain hydrogen bond interaction leads to a high glass transition temperature of EC, which makes it too brittle to be used widely. The hydroxyl group on EC can form a supramolecular system in the form of a non-covalent bond with an effective plasticizer. In this study, an important vegetable-oil-based derivative named dimer fatty acid was used to prepare a novel special plasticizer for EC. Dimer-fatty-acid-based thioether polyol (DATP) was synthesized and used to modify ethyl cellulose films. The supramolecular composite films of DATP and ethyl cellulose… More > Graphic Abstract

Qian Liu¹, Sayikal Duyxanale¹, Yongqian Tang², Xinyu Shen¹, Yuanlai Zhao¹, Xinru Ma¹, Shuai Shao¹, Chenfei Liang^1,*

Phyton-International Journal of Experimental Botany, Vol.92, No.3, pp. 943-954, 2023, DOI:10.32604/phyton.2022.023225

Abstract Chinese hickory (Carya cathayensis Sarg.) is an important economic forest in Southeastern China. A large amount of hickory husk waste is generated every year but with a low proportion of returning. Meanwhile, intensive management has resulted in soil degradation of Chinese hickory plantations. This study aims to investigate the effects of three Chinese hickory husk returning modes on soil amendment, including soil acidity, soil nutrition, and microbial community. The field experiment carried out four treatments: control (CK), hickory husk mulching (HM), hickory husk biochar (BC), and hickory husk organic fertilizer (OF). The phospholipid fatty acid (PLFA) biomarker method was employed… More >