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  • Open Access


    A Review on Sources, Extractions and Analysis Methods of a Sustainable Biomaterial: Tannins

    Antonio Pizzi1,*, Marie-Pierre Laborie2,3, Zeki Candan4

    Journal of Renewable Materials, Vol.12, No.3, pp. 397-425, 2024, DOI:10.32604/jrm.2023.046074

    Abstract Condensed and hydrolysable tannins are non-toxic natural polyphenols that are a commercial commodity industrialized for tanning hides to obtain leather and for a growing number of other industrial applications mainly to substitute petroleum-based products. They are a definite class of sustainable materials of the forestry industry. They have been in operation for hundreds of years to manufacture leather and now for a growing number of applications in a variety of other industries, such as wood adhesives, metal coating, pharmaceutical/medical applications and several others. This review presents the main sources, either already or potentially commercial of this forestry by-materials, their industrial… More > Graphic Abstract

    A Review on Sources, Extractions and Analysis Methods of a Sustainable Biomaterial: Tannins

  • Open Access


    Drought-Mediated Modulation in Metabolomic Profiling of Leaf, Growth, Ecophysiology and Antioxidants

    Khalid Rehman Hakeem1,2,3,*, Hesham F. Alharby1, M. Irfan Qureshi4

    Phyton-International Journal of Experimental Botany, Vol.92, No.12, pp. 3323-3344, 2023, DOI:10.32604/phyton.2023.030212


    Abiotic stresses, including drought, have been found to affect the growth and medicinal quality of numerous herbs. The proposed study aims to study the effects of different drought regimes on the metabolic profile, growth, ecophysiology, cellular antioxidants, and antioxidant potential of Nigella sativa (Black cumin) leaf. Forty-day-old seedlings of N. sativa were exposed to three regimes of drought (control, moderate and high) for a week. UPLC-MS/MS metabolic profile of the leaf reveals the presence of more than a hundred metabolites belonging to anthocyanins, chalcones, dihydro flavonoids, flavonoids, flavanols, flavones, flavonoid carbonoside, isoflavones, etc. Drought was found to alter the contents… More >

  • Open Access


    Comparison of Apigenin, Quercetin and Kaempferol Accumulation and Total Flavonoid Content in Leaves, Embryogenic Cultures and Cell Suspension Cultures of Parsley (Petroselinum crispum)

    Laura Isabel Arias-Rodríguez1, Martha Alicia Rodríguez-Mendiola2,*, Carlos Arias-Castro2,*, Federico Antonio Gutiérrez Miceli1, Diana Reséndez Pérez3, María Celina Luján Hidalgo1, Juan José Villalobos Maldonado1, Norma Alejandra Mancilla Margalli2

    Phyton-International Journal of Experimental Botany, Vol.92, No.10, pp. 2807-2823, 2023, DOI:10.32604/phyton.2023.030396

    Abstract In recent years, there has been a growing interest in exploring alternative treatments for bone defects. Bone tissue engineering has turned its attention to plant extracts containing osteogenic flavonoids as potential promoters of bone regeneration. In our study, we specifically investigated the extract of Petroselinum crispum, a plant known for its abundance of osteogenic flavonoids such as apigenin, quercetin, and kaempferol. Our objective was to compare the total flavonoid content (TFC) and their accumulation in different sources. We obtained hydrolyzed aqueous extracts from the leaves of parsley plants (grown for 12 weeks in the field), weekly embryogenic cultures, and suspension… More >

  • Open Access


    Flavonoids in safflower extract reduce cisplatin-induced damage to human follicle dermal papilla cells by inhibiting DNA damage and Rad17/Chk1/Cdc25C signaling


    BIOCELL, Vol.47, No.8, pp. 1793-1802, 2023, DOI:10.32604/biocell.2023.030093

    Abstract Background: Cisplatin is a chemotherapeutic agent commonly used clinically for the treatment of various human cancers. Patients often reduce the use of cisplatin due to its side effects, which in turn affects its treatment. This study explored the mechanism of action of safflower extract as an adjuvant traditional Chinese medicine for chemotherapy. Methods: Primary human follicle dermal papilla cells (HFDPCs) were used as target cells for cisplatin-induced damage to hair cells. Western blotting was used to investigate the molecular targets of cisplatin and safflower extract in causing HFDPCs damage. Cell survival and cell cycle were analyzed by mitochondrial staining reagent… More >

  • Open Access


    Extraction, Antioxidant Activity and Identification of Flavonoids from Root Tubers of Kosteletzkya virginica

    Yu Zai*, Shaohua Liu

    Phyton-International Journal of Experimental Botany, Vol.92, No.1, pp. 225-236, 2023, DOI:10.32604/phyton.2022.022576

    Abstract Kosteletzkya virginica (K. virginica) is used for revegetation of salt-affected coastal tidal flats and as a raw material of biodiesel. K. virginica root tuber, a biowaste with low economic value, is rich in bioactive compounds. This study aimed to extract and identify flavonoids from K. virginica root tubers. The optimal extraction conditions were 1/25 (w/v) solid/liquid ratio, 40% ethanol concentration at 40°C for 60 min. Under these conditions, 65.2 ± 3.7 mg/g total flavonoid content was extracted from the roots, which were collected from salinized soil in late autumn of the third year. Antioxidant activity was evaluated through 1,1-diphenyl-2-picrylhydrazyl, hydroxyl… More >

  • Open Access


    Transcriptome Profiling of Flower Development Reveals Key Genes Mediating Yellow Formation in Tree Peony

    Yanzhao Zhang*, Chenyang Yu, Xi Lu, Yanwei Cheng

    Phyton-International Journal of Experimental Botany, Vol.91, No.11, pp. 2505-2518, 2022, DOI:10.32604/phyton.2022.021455

    Abstract Tree peony cultivars with yellow flowers are rare and valuable, but the molecular mechanism of pigment accumulation is not clear. In this study, the petal transcriptome of three developmental stages were sequenced to determine the differentially expressed genes (DEGs) regulating yellow flowers color. The results showed that 10,842 and 12,022 DEGs were screened in stage 1 vs. stage 2 and in stage 2 vs. stage 3, respectively. Through analysis of flavonoid structural genes (FSGs), we found that the transcription level of DFR was very low in the three developmental stages. In a small group of cultivars, the DFR transcription level… More >

  • Open Access


    The Potential Toxic Side Effects of Flavonoids


    BIOCELL, Vol.46, No.2, pp. 357-366, 2022, DOI:10.32604/biocell.2022.015958

    Abstract Flavonoids are a class of phytochemical molecules abundant in many plants, fruits, vegetables, and leaves. Flavonoids possess a series of significant biological activities, including anticancer, antioxidant, antiviral, and antiinflammatory properties. They become an important source of dietary supplements and natural health products. Though many studies confirmed the safety of flavonoids, the potential toxicity of flavonoids is still a remarkable field of research to be explored. The enthusiasm for flavonoids expressed by the public has sometimes overlooked their toxicity and also consumed the flavonoids exceeding the body requirements. The current review focused on the potential toxicity of flavonoids to make the… More >

  • Open Access


    Differential metabolome landscape of Kadsura coccinea fruit tissues and potential valorization of the peel and seed tissues


    BIOCELL, Vol.46, No.1, pp. 285-296, 2022, DOI:10.32604/biocell.2021.016253

    Abstract Kadsura coccinea (Lem.) is a woody wine plant with a peculiar fruit enriched in important health-promoting compounds. The non-editable part of the fruit, i.e., the seed and peel, represents more than 60% of the fruit and is considered a biowaste. This significantly restricts the development of the K. coccinea fruit industry. Clarifying the metabolic components of the different fruit parts can help to improve the utilization rate and valorization of K. coccinea. Herein, we evaluated K. coccinea fruit peel, pulp, and seed using widely-targeted metabolomics and quantified a set of 736 bioactive compounds from 11 major metabolite classes. The most… More >

  • Open Access


    Phytochemical Analysis and Antioxidant Activity of Crocus speciosus Leaves

    Olha Mykhailenko1,*, Ivan Bezruk1, Victoriia Volochai2, Volodymyr Mishchenko3, Liudas Ivanauskas4, Victoriya Georgiyants1

    Phyton-International Journal of Experimental Botany, Vol.91, No.1, pp. 207-221, 2022, DOI:10.32604/phyton.2022.016458

    Abstract The numerous studies indicate leaves of plants are a rich source of bioactive compounds that can be a valuable source of compounds used in the pharmaceutical and cosmetic industries. Aim of this study was to investigate the chemical composition and the antioxidant property of Crocus speciosus leaves. Primary phytochemical screening of C. speciosus leaves revealed the presence of some following compound categories such as phenolic compounds, aminoacids, saponins, proteins, tannins, triterpenoids, glycosides, polysaccharides. The total flavonoids and phenolic compounds content were determined spectrophotometrically and by HPLC-DAD and HPLC-MS. Antiradical activity was determined by ABTS radical-cation scavenging method, spectrophotometrically. The total… More >

  • Open Access


    Chemical Constituents of Pedicularis longiflora var. tubiformis (Orobanchaceae), a Common Hemiparasitic Medicinal Herb from the Qinghai Lake Basin, China

    Feng Liu1,2,3, Zilan Ma1,2,3, Marcos A. Caraballo-Ortiz4, Hui Zhang5, Xu Su1,2,3, Yuping Liu1,2,3,*

    Phyton-International Journal of Experimental Botany, Vol.89, No.4, pp. 1083-1090, 2020, DOI:10.32604/phyton.2020.011239

    Abstract Pedicularis longiflora var. tubiformis (Orobanchaceae) is an abundant parasitic herb mainly found in the Xiaopohu wetland of the Qinghai Lake Basin in Northwestern China. The species has an important local medicinal value, and in this study, we evaluated the chemical profile of its stems, leaves and seeds using mass spectrometry. Dried samples of stems, leaves and seeds were grinded, weighted, and used for a series of extractions with an ultrasonic device at room temperature. The chemical profiles for each tissue were determined using Gas Chromatography-Mass Spectrometry (GC-MS) and Liquid ChromatographyMass Spectrometry (LC-MS). Twenty-seven amino acids and organic acids were identified… More >

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