Zoran S. Ilić^1,*, Ljiljana Stanojević², Lidija Milenković¹, Ljubomir Šunić¹, Dragana Lalević¹, Aleksandra Milenković², Žarko Kevrešan³

Phyton-International Journal of Experimental Botany, Vol.94, No.8, pp. 2515-2527, 2025, DOI:10.32604/phyton.2025.069082 - 29 August 2025

Abstract This study aims to determine the phytochemical composition and antioxidant activity (AA) of different plant parts (bulbs, stalk, leaves and flowers) of wild rosy garlic (Allium roseum) from Montenegro. The flower exhibited the highest concentration of total phenols (55.7 GAE/g d.e.), followed by the leaf (25.6 mg GAE/g d.e.). The leaf displayed the highest concentration of total flavonoids (41.48 mg RE/g d.e.), followed by the flower (36.26 mg RE/g d.e.) and top part of the stalk (26.80 mg RE/g d.e.). The AA of different parts of A. roseum after 60 min of incubation decreased in the following… More >

Menghan Li^1,2,#, Yuhui He^1,#, Changning Chen², Li Liu², Jia Xu², Jiahao Cao^1,2, Xiaotong Guo^1,*, Linlin Dong^1,2,*

Phyton-International Journal of Experimental Botany, Vol.94, No.8, pp. 2575-2591, 2025, DOI:10.32604/phyton.2025.064518 - 29 August 2025

Abstract Codonopsis pilosula is a major Qi-tonifying medicinal herb, and its active composition is analyzed systematically. However, the relationship between its production origins and commodity specification grades with the active composition of C. pilosula lacks systematic research. This study integrates the HPLC and UV-Vis methodologies to evaluate the quality of C. pilosula from commodity specification grades and different origins, and it explores the correlation between ecological factors and production origins with active components. Here, network pharmacology is used to determine that lobetyolin, syringin, and tangshenoside I have potential efficacy in treating pulmonary fibrosis and oxidative stress. The HPLC and… More >

Lesya Voytenko^1,*, Mykola Shcherbatiuk¹, Valentyna Vasyuk¹, Kateryna Romanenko¹, Lidiya Babenko¹, Oleksandr Smirnov^2,3, Iryna Kosakivska¹

Phyton-International Journal of Experimental Botany, Vol.94, No.7, pp. 2195-2214, 2025, DOI:10.32604/phyton.2025.067772 - 31 July 2025

Abstract Prolonged lack of rain and high-temperature lead to soil water deficits, inhibiting cereal crop growth in early ontogenesis and reducing grain quality and yield. Rye (Secale cereale L.) is a key grain crop, particularly in regions where wheat cultivation is challenging or unfeasible. To clarify its drought adaptation mechanisms, we analyzed the effects of moderate soil drought on growth, hormonal homeostasis, and the dynamics and distribution of free amino acids and phenolic compounds in rye at early vegetative stages and post-recovery. Drought triggered both general and organ-specific changes in endogenous phytohormones. A nonspecific response involved the… More >

Bismillah Mubeen^1,2,#, Ammarah Hasnain^2,3,#,*, Syed Atif Hasan Naqvi⁴, Fahad Hakim⁵, Syed Sheharyar Hassan Naqvi⁶, Muhammad Zeeshan Hassan⁴, Muhammad Umer Iqbal⁷, Mahmoud Moustafa⁸, Mohammed O. Alshaharni⁸, Mingzheng Duan^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.7, pp. 1941-1971, 2025, DOI:10.32604/phyton.2025.064056 - 31 July 2025

Abstract Plants have long served as a cornerstone for drug discovery, offering a vast repertoire of bioactive compounds with proven efficacy in combating oxidative stress, a pivotal driver of chronic diseases such as cancer, diabetes, cardiovascular disorders, and neurodegenerative conditions. This review synthesizes current knowledge on plant-derived antioxidants, emphasizing their mechanisms, therapeutic potential, and quantitative efficacy validated through standardized assays. Key phytochemicals, including polyphenols, carotenoids, flavonoids, and terpenoids, neutralize reactive oxygen species (ROS) through radical scavenging, enzyme modulation, and gene regulation. For instance, lutein, a carotenoid found in leafy greens, demonstrates potent antioxidant activity with IC₅₀ values… More >

Claude Y. Hamany Djande, Paul A. Steenkamp, Ian A. Dubery^*

Phyton-International Journal of Experimental Botany, Vol.94, No.4, pp. 1269-1286, 2025, DOI:10.32604/phyton.2025.062392 - 30 April 2025

Abstract Centella asiatica L., a medicinal herb, has attracted substantial interest in research as well as commercial domains due to its bioactive compounds which include the pentacyclic triterpenoid centellosides, and in addition, hydroxy. In addition, hydroxycinnamic acid conjugates as well as flavonoids. The latter is the major class of secondary plant metabolites and comprises various subclasses, including anthocyanidins. Anthocyanins are rarely reported in extracts from C. asiatica and differ structurally due to a flavylium (2-phenylchromenylium) ion that carries a positive charge at the oxygen atom of the C-ring of the basic flavonoid structure. Callus of C. asiatica was initiated… More >

Lili Liu¹, Can Hu⁴, Huilin Cheng¹, Chuangju Ma¹, Jiancheng Sun¹, Yunyi Chen², Manxi Wu², Han Yang², Cui Sun^2,3, Jinping Cao^2,3, Dengliang Wang^1,*, Yue Wang^2,*, Chongde Sun^2,3

Phyton-International Journal of Experimental Botany, Vol.93, No.9, pp. 2499-2518, 2024, DOI:10.32604/phyton.2024.054449 - 30 September 2024

Abstract Oral ulcers, a common mucosal affliction, severely diminish patients’ quality of life due to pain and discomfort. Despite existing treatments, the frequent recurrence of oral ulcers underscores the need for more effective therapeutic options. This study aimed to investigate the inhibitory effects of Ponkan (Citrus reticulata ‘Ponkan’) extracts and their flavonoid components on oral ulcers, exploring their potential as a natural therapy. Twenty different Ponkan cultivars were selected for flavonoid extraction and analysis. Ultra-performance liquid chromatography (UPLC) and high-resolution mass spectrometry (HRMS) were utilized for substance identification, leading to the discovery of 16 flavonoid compounds. Using… More > Graphic Abstract

Fenglan Zhao^1,2,#, Shuwen Wu^1,#, Xue Meng¹, Jianping Xue^1,2, Yongbo Duan^1,2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.7, pp. 1705-1716, 2024, DOI:10.32604/phyton.2024.052287 - 30 July 2024

Abstract Dōng líng căo, the dried aboveground parts of Isodon rubescens (Hemls.) Hara., is commonly consumed as a medicinal decoction or tea beverage. Natural beverages can be an important source of human dietary selenium (Se). However, how I. rubescens plants respond to exogenous Se remains unknown. In this study, a pot cultivation experiment was employed to investigate the phenotypic and physiological responses of I. rubescens plants exposed to Se. Fifteen days after applying different concentrations of sodium selenate to the soil, the Se enrichment capacity, growth indices, antioxidant capacities, and the content of flavonoids and diterpenoids were measured in… More >

Antonio Pizzi^1,*, Marie-Pierre Laborie^2,3, Zeki Candan⁴

Journal of Renewable Materials, Vol.12, No.3, pp. 397-425, 2024, DOI:10.32604/jrm.2023.046074 - 11 April 2024

Abstract Condensed and hydrolysable tannins are non-toxic natural polyphenols that are a commercial commodity industrialized for tanning hides to obtain leather and for a growing number of other industrial applications mainly to substitute petroleum-based products. They are a definite class of sustainable materials of the forestry industry. They have been in operation for hundreds of years to manufacture leather and now for a growing number of applications in a variety of other industries, such as wood adhesives, metal coating, pharmaceutical/medical applications and several others. This review presents the main sources, either already or potentially commercial of More > Graphic Abstract

Khalid Rehman Hakeem^1,2,3,*, Hesham F. Alharby¹, M. Irfan Qureshi⁴

Phyton-International Journal of Experimental Botany, Vol.92, No.12, pp. 3323-3344, 2023, DOI:10.32604/phyton.2023.030212 - 28 December 2023

Abstract

Abiotic stresses, including drought, have been found to affect the growth and medicinal quality of numerous herbs. The proposed study aims to study the effects of different drought regimes on the metabolic profile, growth, ecophysiology, cellular antioxidants, and antioxidant potential of Nigella sativa (Black cumin) leaf. Forty-day-old seedlings of N. sativa were exposed to three regimes of drought (control, moderate and high) for a week. UPLC-MS/MS metabolic profile of the leaf reveals the presence of more than a hundred metabolites belonging to anthocyanins, chalcones, dihydro flavonoids, flavonoids, flavanols, flavones, flavonoid carbonoside, isoflavones, etc. Drought was found to

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Laura Isabel Arias-Rodríguez¹, Martha Alicia Rodríguez-Mendiola^2,*, Carlos Arias-Castro^2,*, Federico Antonio Gutiérrez Miceli¹, Diana Reséndez Pérez³, María Celina Luján Hidalgo¹, Juan José Villalobos Maldonado¹, Norma Alejandra Mancilla Margalli²

Phyton-International Journal of Experimental Botany, Vol.92, No.10, pp. 2807-2823, 2023, DOI:10.32604/phyton.2023.030396 - 15 September 2023

Abstract In recent years, there has been a growing interest in exploring alternative treatments for bone defects. Bone tissue engineering has turned its attention to plant extracts containing osteogenic flavonoids as potential promoters of bone regeneration. In our study, we specifically investigated the extract of Petroselinum crispum, a plant known for its abundance of osteogenic flavonoids such as apigenin, quercetin, and kaempferol. Our objective was to compare the total flavonoid content (TFC) and their accumulation in different sources. We obtained hydrolyzed aqueous extracts from the leaves of parsley plants (grown for 12 weeks in the field), weekly… More >