Manisha Choudhari¹, Shantanu Damle², Rajat Vashist¹, Ranendra Narayan Saha³, Sunil Kumar Dubey⁴, Gautam Singhvi^1,*

Journal of Polymer Materials, Vol.42, No.4, pp. 1199-1229, 2025, DOI:10.32604/jpm.2025.072987 - 26 December 2025

Abstract Abiraterone acetate (ABTA) was approved by the USFDA in 2011 for treating metastatic castration-resistant prostate cancer (mCRPC). ABTA exhibits poor aqueous solubility, inadequate dissolution, low oral bioavailability (<10%), and significant positive food effects. To overcome these limitations, in the present work, ABTA solid dispersions (SDs) were developed by using hot melt extrusion technology (HME) with various grades of hydroxypropyl methylcellulose HME (HPMC HME 15LV and 100LV) at different extrusion temperatures. HPMC HME demonstrated the ability to prevent drug precipitation for up to 120 min compared to the free drug (10 min), sustaining the supersaturation state… More > Graphic Abstract

Kangjie Li, Wenjing Ye^*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.2, pp. 1665-1688, 2025, DOI:10.32604/cmes.2025.072447 - 26 November 2025

Abstract Recent progress in topology optimization (TO) has seen a growing integration of machine learning to accelerate computation. Among these, online learning stands out as a promising strategy for large-scale TO tasks, as it eliminates the need for pre-collected training datasets by updating surrogate models dynamically using intermediate optimization data. Stress-constrained lightweight design is an important class of problem with broad engineering relevance. Most existing frameworks use pixel or voxel-based representations and employ the finite element method (FEM) for analysis. The limited continuity across finite elements often compromises the accuracy of stress evaluation. To overcome this… More >

Tao Liu¹, Yang Liu², Jianbin Du^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.4, pp. 1-2, 2025, DOI:10.32604/icces.2025.011595

Abstract Currently, the application of the Boundary Penalty (BP) method in acoustic-structural coupled multiphysics optimization problems remains unexplored. Within the theoretical framework of BP developed previously, we address acoustic-structural coupled topology optimization problems by proposing a BP-based acoustic-structural coupled topology optimization model. A systematic solution strategy is developed to tackle the challenges encountered during model solving.
The proposed model employs a mixed u/p formulation for finite element analysis and the adjoint method for sensitivity analysis to minimize the acoustic pressure within a specified region (Fig.1 A). During optimization iterations, issues such as topological discretization and iteration oscillations… More >

Salvatore Brischetto^*, Domenico Cesare, Tommaso Mondino

CMC-Computers, Materials & Continua, Vol.85, No.3, pp. 4491-4518, 2025, DOI:10.32604/cmc.2025.068518 - 23 October 2025

Abstract A three-dimensional (3D) analytical formulation is proposed to put together magnetic, electric and elastic fields to analyze the vibration modes of simply-supported layered piezo-electro-magnetic plates. The present 3D model allows analyses for layered smart plates in both open-circuit and closed-circuit configurations. The second-order differential equations written in the mixed curvilinear reference system govern the magneto-electro-elastic free vibration problem for multilayered plates. This set consists of the 3D equations of motion and the 3D divergence equations for the magnetic induction and electric displacement. Navier harmonic forms in the planar directions and the exponential matrix method in… More >

Suppakit Eiadtrong^1,2,#, Tan N. Nguyen^3,#,*, Mohamed-Ouejdi Belarbi⁴, Nuttawit Wattanasakulpong^1,2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.3, pp. 2819-2848, 2025, DOI:10.32604/cmes.2025.069481 - 30 September 2025

Abstract An improved meshfree moving-Kriging (MK) formulation for free vibration analysis of functionally graded material-functionally graded carbon nanotube-reinforced composite (FGM-FGCNTRC) sandwich shells is first proposed in this article. The proposed sandwich structure consists of skins of FGM layers and an FGCNTRC core. This structure possesses all the advantages of FGM and FGCNTRC, including high electrical or thermal insulating properties, high fatigue resistance, good corrosion resistance, high stiffness, low density, high strength, and high aspect ratios. Such sandwich structures can be used to replace conventional FGM structures. The present formulation has been established by using an improved More >

Boudjema Bendaho¹, Abdelhak Mesbah¹, Zakaria Belabed^1,2,*

CMC-Computers, Materials & Continua, Vol.85, No.2, pp. 2781-2805, 2025, DOI:10.32604/cmc.2025.069709 - 23 September 2025

Abstract A new quadrilateral finite element IQ4 is developed for the free vibration of carbon nanotube-reinforced composite (CNTRC) perforated plates with a central cutout. By enriching the membrane part and incorporating a projected shear technique, the IQ4 element is proposed to address the known limitations of the standard Q4 element, such as shear locking and limited consistency in the coupling of membrane-bending components. The proposed element is formulated within the FSDT-based framework and assessed through benchmark tests to verify its convergence and accuracy. The governing equations are obtained via the weak form of Hamilton’s principle. Particular… More >

Jinping Xu^1,2, Zhiyun Wang¹, Mo Yang^1,*

Frontiers in Heat and Mass Transfer, Vol.23, No.4, pp. 1151-1163, 2025, DOI:10.32604/fhmt.2025.067925 - 29 August 2025

Abstract In concentric annular pipes, the difference in curvature between the inner and outer wall surfaces creates significant variations in the heat transfer characteristics of the two surfaces. The simplifications of the Dittus-Boelter equation for circular pipes make it unsuitable for the complex flow induced by the geometry and heat transfer coupling effects in annular pipes. This prevents it from accurately predicting the turbulent heat transfer in concentric annular pipes. This paper used realizable κ–ε and low Reynolds number models to conduct numerical simulations of turbulent convective heat transfer in concentric annular pipes and circular pipes.… More >

Sirawit Makaew, Yupaporn Areepong^*, Saowanit Sukparungsee

CMES-Computer Modeling in Engineering & Sciences, Vol.143, No.2, pp. 1617-1634, 2025, DOI:10.32604/cmes.2025.063459 - 30 May 2025

Abstract This study aims to examine the explicit solution for calculating the Average Run Length (ARL) on the triple exponentially weighted moving average (TEWMA) control chart applied to autoregressive model (AR(p)), where AR(p) is an autoregressive model of order p, representing a time series with dependencies on its p previous values. Additionally, the study evaluates the accuracy of both explicit and numerical integral equation (NIE) solutions for AR(p) using the TEWMA control chart, focusing on the absolute percentage relative error. The results indicate that the explicit and approximate solutions are in close agreement. Furthermore, the study More >

Ömer Ekim Genel^*, Hilal Koç, Ekrem Tüfekci

CMC-Computers, Materials & Continua, Vol.82, No.2, pp. 2043-2059, 2025, DOI:10.32604/cmc.2025.060111 - 17 February 2025

Abstract Due to their superior properties, the interest in nanostructures is increasing today in engineering. This study presents a new two-noded curved finite element for analyzing the in-plane static behaviors of curved nanobeams. Opposite to traditional curved finite elements developed by using approximate interpolation functions, the proposed curved finite element is developed by using exact analytical solutions. Although this approach was first introduced for analyzing the mechanical behaviors of macro-scale curved beams by adopting the local theory of elasticity, the exact analytical expressions used in this study were obtained from the solutions of governing equations that… More >

Francesco Tornabene^*, Matteo Viscoti, Rossana Dimitri

CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.2, pp. 1767-1838, 2025, DOI:10.32604/cmes.2024.058842 - 27 January 2025

Abstract Recent engineering applications increasingly adopt smart materials, whose mechanical responses are sensitive to magnetic and electric fields. In this context, new and computationally efficient modeling strategies are essential to predict the multiphysic behavior of advanced structures accurately. Therefore, the manuscript presents a higher-order formulation for the static analysis of laminated anisotropic magneto-electro-elastic doubly-curved shell structures. The fundamental relations account for the full coupling between the electric field, magnetic field, and mechanical elasticity. The configuration variables are expanded along the thickness direction using a generalized formulation based on the Equivalent Layer-Wise approach. Higher-order polynomials are selected,… More >