Yin Liang^1,*, Gaoxu Xu¹, Sadaqat ur Rehman²

CMC-Computers, Materials & Continua, Vol.72, No.3, pp. 4645-4661, 2022, DOI:10.32604/cmc.2022.026999

Abstract Whole brain functional connectivity (FC) patterns obtained from resting-state functional magnetic resonance imaging (rs-fMRI) have been widely used in the diagnosis of brain disorders such as autism spectrum disorder (ASD). Recently, an increasing number of studies have focused on employing deep learning techniques to analyze FC patterns for brain disease classification. However, the high dimensionality of the FC features and the interpretation of deep learning results are issues that need to be addressed in the FC-based brain disease classification. In this paper, we proposed a multi-scale attention-based deep neural network (MSA-DNN) model to classify FC patterns for the ASD diagnosis.… More >

Yuhao Chen¹, Jiajun Liu¹, Yaxi Peng¹, Ziyi Liu², Zhipeng Yang^1,*

Intelligent Automation & Soft Computing, Vol.33, No.3, pp. 1501-1516, 2022, DOI:10.32604/iasc.2022.026346

Abstract As a neural fingerprint, functional connectivity networks (FCNs) have been used to identify subjects from group. However, a number of studies have only paid attention to cerebral cortex when constructing the brain FCN. Other areas of the brain also play important roles in brain activities. It is widely accepted that the human brain is composed of many highly complex functional networks of cortex. Moreover, recent studies have confirmed correlations between signals of cortex and white matter (WM) bundles. Therefore, it is difficult to reflect the functional characteristics of the brain through a single-layer FCN. In this paper, a multilayer FCN… More >

Lan Yang¹, Shun Qi^2,3,#, Chen Qiao^1,*, Yanmei Kang¹

CMES-Computer Modeling in Engineering & Sciences, Vol.125, No.1, pp. 215-237, 2020, DOI:10.32604/cmes.2020.010796

Abstract Schizophrenia (SZ) is one of the most common mental diseases. Its main characteristics are abnormal social behavior and inability to correctly understand real things. In recent years, the magnetic resonance imaging (MRI) technique has been popularly utilized to study SZ. However, it is still a great challenge to reveal the essential information contained in the MRI data. In this paper, we proposed a biomarker selection approach based on the multiple hypothesis testing techniques to explore the difference between SZ and healthy controls by using both functional and structural MRI data, in which biomarkers represent both abnormal brain functional connectivity and… More >

Zhuqing Jiao^{1, *}, Yixin Ji¹, Tingxuan Jiao¹, Shuihua Wang^{2, *}

CMES-Computer Modeling in Engineering & Sciences, Vol.123, No.2, pp. 845-871, 2020, DOI:10.32604/cmes.2020.08999

Abstract Currently, functional connectomes constructed from neuroimaging data have emerged as a powerful tool in identifying brain disorders. If one brain disease just manifests as some cognitive dysfunction, it means that the disease may affect some local connectivity in the brain functional network. That is, there are functional abnormalities in the sub-network. Therefore, it is crucial to accurately identify them in pathological diagnosis. To solve these problems, we proposed a sub-network extraction method based on graph regularization nonnegative matrix factorization (GNMF). The dynamic functional networks of normal subjects and early mild cognitive impairment (eMCI) subjects were vectorized and the functional connection… More >