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  • Open Access

    ARTICLE

    Transcriptome-Wide Identification and Functional Analysis of PgSQE08-01 Gene in Ginsenoside Biosynthesis in Panax ginseng C. A. Mey.

    Lei Zhu1,#, Lihe Hou1,3,#, Yu Zhang1, Yang Jiang1, Yi Wang1,2, Meiping Zhang1,2, Mingzhu Zhao1,2,*, Kangyu Wang1,2,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.2, pp. 313-327, 2024, DOI:10.32604/phyton.2024.047938

    Abstract Panax ginseng C. A. Mey. is an important plant species used in traditional Chinese medicine, whose primary active ingredient is a ginsenoside. Ginsenoside biosynthesis is not only regulated by transcription factors but also controlled by a variety of structural genes. Nonetheless, the molecular mechanism underlying ginsenoside biosynthesis has always been a topic in the discussion of ginseng secondary metabolites. Squalene epoxidase (SQE) is a key enzyme in the mevalonic acid pathway, which affects the biosynthesis of secondary metabolites such as terpenoid. Using ginseng transcriptome, expression, and ginsenoside content databases, this study employed bioinformatic methods to systematically analyze the genes encoding… More >

  • Open Access

    ARTICLE

    Flavonoids in safflower extract reduce cisplatin-induced damage to human follicle dermal papilla cells by inhibiting DNA damage and Rad17/Chk1/Cdc25C signaling

    FU-MING TSAI1, PING-HSUN LU2,3, LU-KAI WANG4, CHAN-YEN KUO1, MAO-LIANG CHEN1, CHUN-HUA WANG5,6,*

    BIOCELL, Vol.47, No.8, pp. 1793-1802, 2023, DOI:10.32604/biocell.2023.030093

    Abstract Background: Cisplatin is a chemotherapeutic agent commonly used clinically for the treatment of various human cancers. Patients often reduce the use of cisplatin due to its side effects, which in turn affects its treatment. This study explored the mechanism of action of safflower extract as an adjuvant traditional Chinese medicine for chemotherapy. Methods: Primary human follicle dermal papilla cells (HFDPCs) were used as target cells for cisplatin-induced damage to hair cells. Western blotting was used to investigate the molecular targets of cisplatin and safflower extract in causing HFDPCs damage. Cell survival and cell cycle were analyzed by mitochondrial staining reagent… More >

  • Open Access

    ARTICLE

    A New Hybrid Model for Segmentation of the Skin Lesion Based on Residual Attention U-Net

    Saleh Naif Almuayqil1, Reham Arnous2,*, Noha Sakr3, Magdy M. Fadel3

    CMC-Computers, Materials & Continua, Vol.75, No.3, pp. 5177-5192, 2023, DOI:10.32604/cmc.2023.038625

    Abstract Skin segmentation participates significantly in various biomedical applications, such as skin cancer identification and skin lesion detection. This paper presents a novel framework for segmenting the skin. The framework contains two main stages: The first stage is for removing different types of noises from the dermoscopic images, such as hair, speckle, and impulse noise, and the second stage is for segmentation of the dermoscopic images using an attention residual U-shaped Network (U-Net). The framework uses variational Autoencoders (VAEs) for removing the hair noises, the Generative Adversarial Denoising Network (DGAN-Net), the Denoising U-shaped U-Net (D-U-NET), and Batch Renormalization U-Net (Br-U-NET) for… More >

  • Open Access

    ARTICLE

    Compact 5G Vivaldi Tapered Slot Filtering Antenna with Enhanced Bandwidth

    Sahar Saleh1,2, Mohd Haizal Jamaluddin1,*, Bader Alali3,4, Ayman A. Althuwayb4

    CMC-Computers, Materials & Continua, Vol.74, No.3, pp. 5983-5999, 2023, DOI:10.32604/cmc.2023.035585

    Abstract Compact fifth-generation (5G) low-frequency band filtering antennas (filtennas) with stable directive radiation patterns, improved bandwidth (BW), and gain are designed, fabricated, and tested in this research. The proposed filtennas are achieved by combining the predesigned compact 5G (5.975 – 7.125 GHz) third-order uniform and non-uniform transmission line hairpin bandpass filters (UTL and NTL HPBFs) with the compact ultrawide band Vivaldi tapered slot antenna (UWB VTSA) in one module. The objective of this integration is to enhance the performance of 5.975 – 7.125 GHz filtennas which will be suitable for modern mobile communication applications by exploiting the benefits of UWB VTSA. Based on… More >

  • Open Access

    ARTICLE

    Efficient Body-Transfer Wheelchair for Assisting Functionally Impaired People

    Chyi-Yeu Lin1,2,3, Bahrudin1, Salman Masroor1,*

    CMC-Computers, Materials & Continua, Vol.74, No.3, pp. 4881-4900, 2023, DOI:10.32604/cmc.2023.032837

    Abstract Functionally impaired people always have difficulty accomplishing activities of daily living. In this regard, tasks including toileting and bathing have a higher prevalence rate of injuries and greater risk of falling. In this study, a body-transfer wheelchair was developed to assist people in transferring from bed to wheelchair for bathing, and toileting. The body-transfer wheelchair is a semi-automatic wheelchair that has features such as a controlled leg and backrest, linkage commode slot, and height adjustment. The wheelchair consists of a seat and a main frame that can be detached to enable bathtub transfer. This mechanism lets the user stay on… More >

  • Open Access

    ARTICLE

    In Vitro and in Silico Insights on the Biological Activities, Phenolic Compounds Composition of Hypericum perforatum L. Hairy Root Cultures

    Oliver Tusevski1,*, Marija Todorovska1, Jasmina Petreska Stanoeva2, Marina Stefova2, Sonja Gadzovska Simic1

    Phyton-International Journal of Experimental Botany, Vol.92, No.3, pp. 921-941, 2023, DOI:10.32604/phyton.2023.024995

    Abstract Three Hypericum perforatum hairy root lines (HR B, HR F and HR H) along with non-transformed roots were analyzed for phenolic compounds composition and in vitro enzyme inhibitory properties. In silico molecular modeling was performed to predict the interactions of the most representative phenolic compounds in HR clones with enzymes related to depression, neurodegeneration and diabetes. Chromatographic analyses revealed that HR clones represent an efficient source of quinic acid and hydroxybenzoic acids, epicatechin and procyanidin derivatives, quercetin and kaempferol glycosides, as well numerous xanthones. In vitro antidepressant activity of HR extracts through monoamine oxidase A (MAO-A) inhibition was attributed to… More >

  • Open Access

    ARTICLE

    Development of Voice Control Algorithm for Robotic Wheelchair Using NIN and LSTM Models

    Mohsen Bakouri1,2,*

    CMC-Computers, Materials & Continua, Vol.73, No.2, pp. 2441-2456, 2022, DOI:10.32604/cmc.2022.025106

    Abstract In this work, we developed and implemented a voice control algorithm to steer smart robotic wheelchairs (SRW) using the neural network technique. This technique used a network in network (NIN) and long short-term memory (LSTM) structure integrated with a built-in voice recognition algorithm. An Android Smartphone application was designed and configured with the proposed method. A Wi-Fi hotspot was used to connect the software and hardware components of the system in an offline mode. To operate and guide SRW, the design technique proposed employing five voice commands (yes, no, left, right, no, and stop) via the Raspberry Pi and DC… More >

  • Open Access

    REVIEW IN FRENCH

    Hairy Cell Leukemia and HCL-Like Disorders: Diagnosis and Treatment
    Leucémie à Tricholeucocytes et Autres Proliférations à Cellules Chevelues: Diagnostic et Traitement

    Elsa Maitre, Xavier Troussard*

    Oncologie, Vol.24, No.1, pp. 3-24, 2022, DOI:10.32604/oncologie.2022.021490

    Abstract Hairy cell leukemia (LT) accounts for 2% of all leukemias. The diagnosis is based on the presence in the blood and/ or the marrow of hairy cells expressing CD103, CD123, CD11c and CD25. The BRAFV600E mutation, a molecular marker of the disease, is present in more than 80% of cases. LT should be distinguished from other chronic B-cell lymphoproliferative disorders, including the variant form of hairy cell leukemia (HCL-V) and diffuse splenic red pulp lymphoma (DSRPL). Progress has recently been made in the management of patients. The purine analogues (PNAs) in monotherapy, deoxycoformycin (DCF) or 2-chloro-deoxyadenosine (CDA), remain the first-line… More >

  • Open Access

    ARTICLE

    A Compact Size 5G Hairpin Bandpass Filter with Multilayer Coupled Line

    Qazwan Abdullah1,2,*, Ömer Aydoĝdu2, Adeeb Salh3, Nabil Farah4, Md Hairul Nizam Talib4, Taha Sadeq5, Mohammed A. A. Al-Mekhalfi3, Abdu Saif6

    CMC-Computers, Materials & Continua, Vol.69, No.3, pp. 4025-4042, 2021, DOI:10.32604/cmc.2021.018798

    Abstract The multilayer structure is a promising technique used to minimize the size of planar microstrip filters. In the flexible design and incorporation of other microwave components, multilayer band-pass filter results in better and enhanced dimensions. This paper introduces a microstrip fifth-generation (5G) low-frequency band of 2.52–2.65 GHz using a parallel-coupled line (PCL) Bandpass filter and multilayer (ML) hairpin Bandpass filter. The targeted four-pole resonator has a center frequency of 2.585 GHz with a bandwidth of 130 MHz. The filters are designed with a 0.1 dB passband ripple with a Chebyshev response. The hairpin-line offers compact filter design structures. Theoretically, they… More >

  • Open Access

    ARTICLE

    Research and Development of a Brain-Controlled Wheelchair for Paralyzed Patients

    Mohammad Monirujjaman Khan1,*, Shamsun Nahar Safa1, Minhazul Hoque Ashik1, Mehedi Masud2, Mohammed A. AlZain3

    Intelligent Automation & Soft Computing, Vol.30, No.1, pp. 49-64, 2021, DOI:10.32604/iasc.2021.016077

    Abstract Smart wheelchairs play a significant role in supporting disabled people. Individuals with motor function impairments due to some disorders such as strokes or multiple sclerosis face frequent moving difficulties. Hence, they need constant support from an assistant. This paper presents a brain-controlled wheelchair model to assist disabled and paralyzed patients. The wheelchair is controlled by interpreting Electroencephalogram (EEG) signals, also known as brain waves. In the EEG technique, an electrode cap is positioned on the user’s scalp to receive EEG signals, which are detected and transformed by the Arduino microcontroller into motion commands, which drive the wheelchair. The proposed wheelchair… More >

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