Shun Maki^1,*, Satoshi Nakano¹, Taiki Haga², Takehiro Niitsu¹, Ikuya Ueta¹

Congenital Heart Disease, Vol.20, No.5, pp. 547-558, 2025, DOI:10.32604/chd.2025.072277 - 30 November 2025

Abstract Background: Considering the limited evidence for acute postoperative nutritional therapy for congenital heart disease (CHD), this study evaluated the effects of achieving enteral nutrition (EN) targets in the acute postoperative phase on clinical outcomes in infants after congenital heart surgery. Methods: This retrospective cohort study, conducted in a multivalent pediatric intensive care unit (PICU), enrolled infants aged ≤6 months following congenital heart surgery between April 2021 and March 2023. Based on the American Society for Parenteral and Enteral Nutrition guidelines, the EN target was defined as two-thirds of the resting energy expenditure with a protein intake… More >

Guozhen Wang^1,2, Yong An^1,2,*

Congenital Heart Disease, Vol.20, No.3, pp. 347-355, 2025, DOI:10.32604/chd.2025.065354 - 11 July 2025

Abstract Background: Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital anomalous coronary artery origin disorder. Objective: We sought to summarize the clinical experience and prognostic characteristics of surgical treatment of ALCAPA. Methods: We retrospectively analyzed clinical information on patients who had ALCAPA and underwent surgery at our center from February 2016 to October 2023. Results: This comparative study of 23 ALCAPA patients (9 infants <1 year; 14 children >1 year) demonstrated significant age-dependent outcomes. Infant patients exhibited markedly prolonged mechanical ventilation (183 ± 105.6 vs. 48.5 ± 62.2 min, p =… More >

Xu Liu, Yanjun Sun, Xiafeng Yu, Yiwei Liu, Hao Zhang^*

Congenital Heart Disease, Vol.20, No.1, pp. 103-113, 2025, DOI:10.32604/chd.2025.063108 - 18 March 2025

Abstract Aorta–right atrial tunnel (ARAT) is an extremely rare congenital heart malformation with an average age of diagnosis of approximately 20 years. Its clinical symptoms are varied and often atypical. ARAT usually originates from the left or right sinus of Valsalva. In this case report, we aim to share a rare case of ARAT originating from the noncoronary sinus in an infant. The patient presented with a cardiac murmur, a dilated right heart, and a tortuous tunnel originating from the dilated noncoronary sinus and terminating at the right atrium in echocardiogram and computed tomography angiography. The More >

Poria Moradi¹, Zahra Naghibifar^2,3, Armin Naghipour^1,*

Congenital Heart Disease, Vol.20, No.1, pp. 77-87, 2025, DOI:10.32604/chd.2025.061784 - 18 March 2025

Abstract Introduction: The occurrence of congenital anomalies is one of the serious challenges in the world. Therefore, identifying related factors to reduce it is of particular importance. This study aimed to determine the incidence and factors related to congenital anomalies. Methods: An epidemiology study was conducted on 1567 infants and their parents in Kermanshah, Iran. The required information was extracted from the files of mothers in health centers. The data collection tool was a researcher-made checklist of 39 questions. The data was statistically analyzed with the STATA version 14 software. Result: The incidence of congenital anomalies was 2.9%… More >

Sameh M. Said^1,2,*, Kristin C. Greathouse³, Christina McCarthy³, Megan Khan³, Molly Hagen⁴, Nicholas Brown⁵, Sacha Kumar⁵, Mahmoud I. Salem⁶, James Flaherty⁷, Yasin Essa¹

Congenital Heart Disease, Vol.19, No.6, pp. 563-575, 2024, DOI:10.32604/chd.2025.061819 - 27 January 2025

Abstract Objective: Vertical right thoracotomy (VRAT) has become an alternative to sternotomy for the repair of non-complex congenital heart defects in our infants and children. Summary Background Data: Limited data exists on the comparison of the two approaches. Methods: The present study consisted of two groups; Group I: (sternotomy; 33 patients) and Group II: (VRAT; 35 patients). We compared the two groups on operative data, hours of invasive lines, narcotics used, length of stay, and total variable cost of stay. Results: The most frequent procedures were atrial and ventricular septal defect closure (25 patients, 75.8% in Group I)… More >

Xiaofeng Wang^#, Chenyu Li^#, Xia Li, Zhongyuan Lu, Xu Wang^*

Congenital Heart Disease, Vol.19, No.6, pp. 617-626, 2024, DOI:10.32604/chd.2025.058712 - 27 January 2025

Abstract Objectives: Fluid overload is common after congenital cardiac surgeries. This requires early application of peritoneal dialysis (PD) in infants to improve surgical outcomes. The objective of this study is to ascertain the factors correlated with the necessity for PD in infants, thereby informing the prophylactic placement of PD catheters intraoperatively. Methods: This was a single-center retrospective study. Infants aged three months or younger who underwent congenital cardiac procedures at the Fuwai Hospital between 2021 and 2022 were included. Patients with chronic renal failure or without RACHS-1 categories were excluded. Based on whether postoperative PD treatment… More >

Jiajun Xu^1,#, Zhuo Shi^2,#, Shanshan Shi^1,*, Xiangming Fan^2,*

Congenital Heart Disease, Vol.19, No.5, pp. 535-540, 2024, DOI:10.32604/chd.2024.057558 - 31 December 2024

Abstract Interrupted Aortic Arch (IAA) combined with aortic stenosis (AS) is a rare and complex congenital cardiac anomaly that presents significant challenges in clinical management. In this letter, we aim to share our experience in performing hybrid procedures on an infant diagnosed with IAA combined with bicuspid AS. This child exhibited significant recovery during follow-up. More >

Sameh M. Said^1,2,*, Yasin Essa¹

Congenital Heart Disease, Vol.19, No.4, pp. 407-417, 2024, DOI:10.32604/chd.2024.055636 - 31 October 2024

Abstract Minimally invasive approaches for cardiac surgery in children have been lagging in comparison to the adult world. A wide range of the most common congenital heart defects in infants and children can be repaired successfully through a variety of non-sternotomy incisions. This has been shown to be associated with superior cosmetic results, shorter hospital stays, and rapid return to full activity compared to sternotomy. These approaches have been around for decades, but they have not been widely adopted for a variety of reasons. Right axillary thoracotomy is one of these approaches that we believe should More >

ZIYONG LIU^1,#, TAO MA^1,#, JINFANG LI², WEI REN^1,*, ZHIXIN ZHANG^1,*

Oncology Research, Vol.32, No.9, pp. 1453-1465, 2024, DOI:10.32604/or.2024.048315 - 23 August 2024

Abstract Background: Interleukin 13 receptor subunit alpha 2 (IL13RA2) plays an essential role in the progression of many cancers. However, the role of IL13RA2 in infantile haemangioma (IH) is still unknown. Materials and Methods: IL13RA2 expression in IH tissues was analyzed using western blot, qRT-PCR, and immunofluorescence. The role of IL13RA2 in haemangioma-derived endothelial cells (HemECs) was determined following knockdown or overexpression of IL13RA2 using CCK-8, colony formation, apoptosis, wound healing, tubule formation, Transwell, and western blot. Results: IL13RA2 expression was upregulated in IH tissues. IL13RA2 overexpression promoted proliferation, migration, and invasion of HemECs and induced glycolysis, More >

Toshi Maeda^*, Hiroki Ito, Keiichi Hirose, Kisaburo Sakamoto

Congenital Heart Disease, Vol.19, No.2, pp. 177-183, 2024, DOI:10.32604/chd.2024.050945 - 16 May 2024

Abstract Congenital aortic stenosis (cAS) frequently requires intervention during the neonatal or infantile period. However, surgical repair is challenging because of the narrow surgical space. We performed bicuspidization using the open-sleeve technique for cAS with a unicuspid aortic valve in two patients. Postoperatively, the patients were doing well without reintervention for the aortic valve for 8 and 6 years, respectively. Their aortic annular diameter increased along with somatic growth. Bicuspidization for neonates or infancy can be performed safely using the open-sleeve technique as its midterm results have been satisfactory. More > Graphic Abstract