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  • Open Access


    Upregulation of Zip14 correlates with induction of endoplasmic reticulum stress (ERS) in hypertrophied hearts of Dahl salt-sensitive rats


    BIOCELL, Vol.46, No.3, pp. 667-675, 2022, DOI:10.32604/biocell.2021.015917

    Abstract Zinc is a trace element involved in maintaining cellular structure and function. Although zinc is associated with left ventricular hypertrophy (LVH), there have been few reports on this association. This study aimed to evaluate the correlation between Zip14 and expression of endoplasmic reticulum stress (ERS) associated molecules in hypertrophied hearts of rats. Dahl salt-sensitive rats were fed a high salt diet to establish a left ventricular hypertrophy (LVH) rat model. RT-PCR was used to determine Zip14, activating transcription factor (ATF4), ATF6, x-box-binding protein 1 (xBP1), C/EBP homologous protein (CHOP), immunoglobulin-binding protein (BiP) mRNA expression. Western blotting was used to evaluate… More >

  • Open Access


    Review of Computational Techniques for the Analysis of Abnormal Patterns of ECG Signal Provoked by Cardiac Disease

    Revathi Jothiramalingam1, Anitha Jude2, Duraisamy Jude Hemanth2,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.128, No.3, pp. 875-906, 2021, DOI: 10.32604/cmes.2021.016485

    Abstract The 12-lead ECG aids in the diagnosis of myocardial infarction and is helpful in the prediction of cardiovascular disease complications. It does, though, have certain drawbacks. For other electrocardiographic anomalies such as Left Bundle Branch Block and Left Ventricular Hypertrophy syndrome, the ECG signal with Myocardial Infarction is difficult to interpret. These diseases cause variations in the ST portion of the ECG signal. It reduces the clarity of ECG signals, making it more difficult to diagnose these diseases. As a result, the specialist is misled into making an erroneous diagnosis by using the incorrect therapeutic technique. Based on these concepts,… More >

  • Open Access


    Circulating biomarkers of left ventricular hypertrophy in pediatric coarctation of the aorta

    Benjamin S. Frank1, Tracy T. Urban2, Karlise Lewis2, Suhong Tong3, Courtney Cassidy4, Max B. Mitchell5, Christopher S. Nichols6, Jesse A. Davidson1

    Congenital Heart Disease, Vol.14, No.3, pp. 446-453, 2019, DOI:10.1111/chd.12744

    Abstract Objective: Patients undergoing surgical repair of aortic coarctation have a 50% risk of pathologic left ventricular remodeling (increased left ventricular mass or relative wall thickness). Endothelin 1, ST2, galectin 3, norepinephrine and B‐natriuretic pep‐ tide are biomarkers that have been associated with pathologic LV change in adult populations but their predictive value following pediatric coarctation repair are not known.
    Hypothesis: Biomarker levels at coarctation repair will predict persistent left ven‐ tricular remodeling at 1‐year follow up.
    Design: Prospective, cohort study of 27 patients’ age 2 days‐12 years with coarcta‐ tion of the aorta undergoing surgical repair. Echocardiograms were performed pre‐… More >

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