YOUSEF KATIB^1,*, NASSER MULLA²

Oncology Research, Vol.32, No.11, pp. 1803-1809, 2024, DOI:10.32604/or.2024.052358 - 16 October 2024

Abstract Background: Lung cancer (LC) is one of the most common neoplastic diseases and a leading cause of death in Saudi Arabia. Its incidence in Saudi Arabia has increased by more than 3% within two decades. Our study aimed to describe the epidemiological and genetic landscapes of LC in Al-Madinah city in Saudi Arabia. Methods: A retrospective analysis was conducted on the medical records of 65 patients diagnosed with lung cancer between 2015 and 2021 at a single medical oncology center in Al-Madinah city of Saudi Arabia. Results: The mean patients’ age was 59.2 years, with 50… More >

Rabia Javed¹, Tanzila Saba², Tahani Jaser Alahmadi^3,*, Sarah Al-Otaibi⁴, Bayan AlGhofaily², Amjad Rehman²

CMC-Computers, Materials & Continua, Vol.81, No.1, pp. 809-825, 2024, DOI:10.32604/cmc.2024.052755 - 15 October 2024

Abstract Cancer poses a significant threat due to its aggressive nature, potential for widespread metastasis, and inherent heterogeneity, which often leads to resistance to chemotherapy. Lung cancer ranks among the most prevalent forms of cancer worldwide, affecting individuals of all genders. Timely and accurate lung cancer detection is critical for improving cancer patients’ treatment outcomes and survival rates. Screening examinations for lung cancer detection, however, frequently fall short of detecting small polyps and cancers. To address these limitations, computer-aided techniques for lung cancer detection prove to be invaluable resources for both healthcare practitioners and patients alike.… More >

Nahed Tawfik^1,*, Heba M. Emara², Walid El-Shafai³, Naglaa F. Soliman⁴, Abeer D. Algarni⁴, Fathi E. Abd El-Samie⁴

CMC-Computers, Materials & Continua, Vol.81, No.1, pp. 271-307, 2024, DOI:10.32604/cmc.2024.052404 - 15 October 2024

Abstract Lung cancer remains a major concern in modern oncology due to its high mortality rates and multifaceted origins, including hereditary factors and various clinical changes. It stands as the deadliest type of cancer and a significant cause of cancer-related deaths globally. Early diagnosis enables healthcare providers to administer appropriate treatment measures promptly and accurately, leading to improved prognosis and higher survival rates. The significant increase in both the incidence and mortality rates of lung cancer, particularly its ranking as the second most prevalent cancer among women worldwide, underscores the need for comprehensive research into efficient… More >

ZHIGUO WANG^1,2,#, KUNLIN LI^2,#, CONGHUA LU², MINGXIA FENG², CAIYU LIN², GUOFANG YIN¹, DAN LUO¹, WENYI LIU³, KAIYU JIN⁴, YUANYAO DOU², DI WU², JIE ZHENG², KEJUN ZHANG⁵, LI LI^2,*, XIANMING FAN^1,*

Oncology Research, Vol.32, No.10, pp. 1637-1648, 2024, DOI:10.32604/or.2024.052664 - 18 September 2024

Abstract Background: Metformin has pleiotropic effects beyond glucose reduction, including tumor inhibition and immune regulation. It enhanced the anti-tumor effects of programmed cell death protein 1 (PD-1) inhibitors in serine/threonine kinase 11 (STK11) mutant non-small cell lung cancer (NSCLC) through an axis inhibition protein 1 (AXIN1)-dependent manner. However, the alterations of tumor metabolism and metabolites upon metformin administration remain unclear. Methods: We performed untargeted metabolomics using liquid chromatography (LC)-mass spectrometry (MS)/MS system and conducted cell experiments to verify the results of bioinformatics analysis. Results: According to the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database, most… More > Graphic Abstract

WEIGANG XIU^1,#, XINGYU LIU^1,2,#, KAIXIN HU^1,2, QIN ZHANG^3,*, HUASHAN SHI^4,*

Oncology Research, Vol.32, No.10, pp. 1613-1621, 2024, DOI:10.32604/or.2024.047933 - 18 September 2024

Abstract Elevated serum cholesterol metabolism is associated with a reduced risk of lung cancer. Disrupted cholesterol metabolism is evident in both lung cancer patients and tumor cells. Inhibiting tumor cell cholesterol uptake or biosynthesis pathways, through the modulation of receptors and enzymes such as liver X receptor and sterol-regulatory element binding protein 2, effectively restrains lung tumor growth. Similarly, promoting cholesterol excretion yields comparable effects. Cholesterol metabolites, including oxysterols and isoprenoids, play a crucial role in regulating cholesterol metabolism within tumor cells, consequently impacting cancer progression. In lung cancer patients, both the cholesterol levels in the… More >

Pouyan Razmjouei¹, Elaheh Moharamkhani², Mohamad Hasanvand³, Maryam Daneshfar⁴, Mohammad Shokouhifar^5,*

CMC-Computers, Materials & Continua, Vol.80, No.3, pp. 3855-3880, 2024, DOI:10.32604/cmc.2024.054460 - 12 September 2024

Abstract This study investigates the application of deep learning, ensemble learning, metaheuristic optimization, and image processing techniques for detecting lung and colon cancers, aiming to enhance treatment efficacy and improve survival rates. We introduce a metaheuristic-driven two-stage ensemble deep learning model for efficient lung/colon cancer classification. The diagnosis of lung and colon cancers is attempted using several unique indicators by different versions of deep Convolutional Neural Networks (CNNs) in feature extraction and model constructions, and utilizing the power of various Machine Learning (ML) algorithms for final classification. Specifically, we consider different scenarios consisting of two-class colon… More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.9, pp. 1527-1527, 2024, DOI:10.32604/or.2024.056120 - 23 August 2024

Abstract This article has no abstract. More >

TATIANA KURILO^*, REBECCA D. PENTZ

Oncology Research, Vol.32, No.9, pp. 1401-1406, 2024, DOI:10.32604/or.2024.050266 - 23 August 2024

Abstract Objectives: Rural patients have poor cancer outcomes and clinical trial (CT) enrollment compared to urban patients due to attitudinal, awareness, and healthcare access differential. Knowledge of cancer survival disparities and CT enrollment is important for designing interventions and innovative approaches to address the stated barriers. The study explores the potential disparities in cancer survival rates and clinical trial enrollments in rural and urban breast and lung cancer patients. Our hypotheses are that for both cancer types, urban cancer patients will have longer 5-year survival rates and higher enrollment rates in clinical trials than those in… More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.8, pp. 1377-1377, 2024, DOI:10.32604/or.2024.055033 - 17 July 2024

Abstract This article has no abstract. More >

XIAOBI HUANG^1,#, CHUNYUAN CHEN², YONGYANG CHEN^1,#, HONGLIAN ZHOU¹, YONGHUA CHEN¹, ZHONG HUANG¹, YULIU XIE¹, BAIYANG LIU¹, YUDONG GUO¹, ZHIXIONG YANG¹, GUANGHUA CHEN^3,*, WENMEI SU^1,4,*

Oncology Research, Vol.32, No.7, pp. 1185-1195, 2024, DOI:10.32604/or.2023.030771 - 20 June 2024

Abstract Background: Long non-coding RNAs are important regulators in cancer biology and function either as tumor suppressors or as oncogenes. Their dysregulation has been closely associated with tumorigenesis. LINC00265 is upregulated in lung adenocarcinoma and is a prognostic biomarker of this cancer. However, the mechanism underlying its function in cancer progression remains poorly understood. Methods: Here, the regulatory role of LINC00265 in lung adenocarcinoma was examined using lung cancer cell lines, clinical samples, and xenografts. Results: We found that high levels of LINC00265 expression were associated with shorter overall survival rate of patients, whereas knockdown of LINC00265 inhibited proliferation… More >