Mingchao Cai, Chun Yang, Mehmet H. Kural, Richard Bach, David Muccigrosso, Deshan Yang, Jie Zheng, Kristen L. Billiar, Dalin Tang

The International Conference on Computational & Experimental Engineering and Sciences, Vol.19, No.4, pp. 97-104, 2011, DOI:10.3970/icces.2011.019.097

Abstract Image-based computational modeling has been introduced for vulnerable atherosclerotic plaques to identify critical mechanical conditions which may be used for better risk assessment and rupture predictions. In vivo patient-specific coronary plaque models are lagging due to limitations on non-invasive image resolution, flow data, and vessel material properties. We propose a procedure where intravascular ultrasound (IVUS) imaging, biaxial mechanical testing and computational modeling are combined together to acquire better and more complete plaque data and make more accurate plaque vulnerability assessment and predictions. More >

Dae Kyeom Park, Do Kyun Kim, Dong Hee Park, Bong Ju Kim, Jeom Kee Paik, Satya N. Atluri

The International Conference on Computational & Experimental Engineering and Sciences, Vol.19, No.3, pp. 65-66, 2011, DOI:10.3970/icces.2011.019.065

Abstract The global warming has reduced the extent of ice in Arctic region and brought some environmental issues including the rising of sea level and the changing of ecosystem. On the other hand, it is also true that the possibility of using Arctic sea route by trading ships and of developing the subsea resource in the Arctic region by offshore installations is increasingly growing due to the global warming. There are still a lot of challenging issues to be resolved for robust design of ships and offshore structures operating in Arctic region.
The aims of the present study can be… More >

Kuo-Ning Chiang¹, Chan-Yen Chou², Chung-Jung Wu², Chao-Jen Huang², Ming-Chih Yew²

The International Conference on Computational & Experimental Engineering and Sciences, Vol.9, No.3, pp. 130-142, 2009, DOI:10.3970/icces.2009.009.130

Abstract An atomic-level analytical solution, together with a modified Morse potential, has been developed to estimate temperature-dependent thermal expansion coefficients (CTE) and elastic characteristics of bulk metals. In this study, inter-atomic forces are considered as a set of anharmonic oscillator networks which can be described by Morse potential, while the material properties can be defined by these inter-atomic forces; when temperature increases, the vibration of the anharmonic oscillator causes the phenomenon of temperature-dependent material properties. The results of analysis showed that the original Morse potential can give a reasonable prediction of the thermal expansion coefficients and elastic constants of metals at… More >

Qingyu Wang¹, Dalin Tang^1,2,*, Gador Canton³, Zheyang Wu², Thomas S. Hatsukami⁴, Kristen L. Billiar⁵, Chun Yuan⁶

Molecular & Cellular Biomechanics, Vol.15, No.4, pp. 189-201, 2018, DOI:10.32604/mcb.2018.04572

Abstract Cardiovascular diseases are closely linked to atherosclerotic plaque development and rupture. Assessment of plaque vulnerability is of fundamental significance to cardiovascular research and disease diagnosis, prevention, treatment and management. Magnetic resonance image (MRI) data of carotid atherosclerotic plaques from 8 patients (5 male, 3 female; age: 62-83, mean=71) were acquired at the University of Washington (UW), Seattle by the Vascular Imaging Laboratory (VIL) with written informed consent obtained. Patient-specific vessel material properties were quantified using Cine MRI data for modeling use. 3D thin-layer models were used to obtain plaque stress and strain for plaque assessment. A stress-based plaque vulnerability index… More >

Longling Fan^1,§, Jing Yao^2,§, Chun Yang³, Di Xu², Dalin Tang^1,4*

Molecular & Cellular Biomechanics, Vol.13, No.1, pp. 33-55, 2016, DOI:10.3970/mcb.2016.013.044

Abstract Modeling ventricle active contraction based on in vivo data is extremely challenging because of complex ventricle geometry, dynamic heart motion and active contraction where the reference geometry (zero-stress geometry) changes constantly. A new modeling approach using different diastole and systole zero-load geometries was introduced to handle the changing zero-load geometries for more accurate stress/strain calculations. Echo image data were acquired from 5 patients with infarction (Infarct Group) and 10 without (Non-Infarcted Group). Echo-based computational two-layer left ventricle models using one zero-load geometry (1G) and two zero-load geometries (2G) were constructed. Material parameter values in Mooney-Rivlin models were adjusted to match… More >

Chetan D. Kuthe^∗, R.V. Uddanwadiker^†, Alankar Ramteke^‡

Molecular & Cellular Biomechanics, Vol.11, No.2, pp. 113-128, 2014, DOI:10.3970/mcb.2014.011.113

Abstract Biomechanical researches are essential to develop new techniques to improve the clinical relevance. Skeletal muscle generates the force which results in the motion of human body, so it is essential to study the mechanical and structural properties of skeletal muscle. Many researchers have carried out mechanical study of skeletal muscle with in-vivo testing. This work aims to examine anisotropic mechanical behavior of skeletal muscle with in vitro test (tensile test). It is important to understand the mechanical and structural behavior of skeletal muscle when it is subjected to external loading; the research aims to determine the structural properties of skeletal… More >

Molecular & Cellular Biomechanics, Vol.9, No.1, pp. 77-94, 2012, DOI:10.3970/mcb.2012.009.077

Abstract Image-based computational modeling has been introduced for vulnerable atherosclerotic plaques to identify critical mechanical conditions which may be used for better plaque assessment and rupture predictions. In vivo patient-specific coronary plaque models are lagging due to limitations on non-invasive image resolution, flow data, and vessel material properties. A framework is proposed to combine intravascular ultrasound (IVUS) imaging, biaxial mechanical testing and computational modeling with fluid-structure interactions and anisotropic material properties to acquire better and more complete plaque data and make more accurate plaque vulnerability assessment and predictions. Impact of pre-shrink-stretch process, vessel curvature and high blood pressure on stress, strain,… More >

Peter L. Bishay¹, Jan Sladek², Vladimir Sladek², Satya N. Atluri¹

CMC-Computers, Materials & Continua, Vol.29, No.3, pp. 213-262, 2012, DOI:10.3970/cmc.2012.029.213

Abstract A new class of hybrid/mixed finite elements, denoted "HMFEM-C", has been developed for modeling magneto-electro-elastic (MEE) materials. These elements are based on assuming independent strain-fields, electric and magnetic fields, and collocating them with the strain-fields, electric and magnetic fields derived from the primal variables (mechanical displacements, electric and magnetic potentials) at some cleverly chosen points inside each element. The newly developed elements show significantly higher accuracy than the primal elements for the electric, magnetic as well as the mechanical variables. HMFEM-C is invariant through the use of the element-fixed local orthogonal base vectors, and is stable since it is not… More >

A. Tadeu¹, P. Stanak², J. Antonio¹, J. Sladek², V. Sladek²

CMES-Computer Modeling in Engineering & Sciences, Vol.107, No.5, pp. 345-378, 2015, DOI:10.3970/cmes.2015.107.345

Abstract This paper implements a numerical method based on the mutual coupling of the boundary element method (BEM) and the meshless local Petrov-Galerkin (MLPG) method to simulate elastic wave propagation in fluid-filled boreholes. The fluid-solid interaction is solved in the frequency domain assuming longitudinally invariant geometry in the axial direction (2.5D formulation).
This model is used to assess the influence of the non-homogeneous material properties of a borehole wall that can be caused by a damaged zone, construction process or the ageing of material. The BEM is used to model propagation within the unbounded homogeneous domain and the fluid domain… More >

Rui Fan¹, Dalin Tang^2,3, Jing Yao⁴, Chun Yang⁵, Di Xu⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.99, No.6, pp. 491-508, 2014, DOI:10.3970/cmes.2014.099.491

Abstract Identifying ventricle material properties and its infarct area after heart attack noninvasively is of great important in clinical applications. An echo-based computational modeling approach was proposed to investigate left ventricle (LV) mechanical properties and stress conditions using patient-specific data. Echo data was acquired from one healthy volunteer (male, age: 58) and a male patient (age: 60) who had an acute inferior myocardial infarction one week before echo image acquisition. Standard echocardiograms were obtained using an ultrasound machine (E9, GE Mechanical Systems, Milwaukee, Wisconsin) with a 3V probe and data were segmented for model construction. Finite element models were constructed to… More >