Lei Ren¹, Jing Hu², Mei Li^1,*, Ling Zhang², Jinyue Xia³

Computer Systems Science and Engineering, Vol.40, No.1, pp. 139-150, 2022, DOI:10.32604/csse.2022.018640

Abstract Lung rehabilitation is safe and feasible, and it has positive benefits in weaning the machine as soon as possible, shortening the time of hospitalization and improving the prognosis of children with mechanical ventilation. However, at present, the traditional medical concept is deep-rooted, and doctors' understanding of early rehabilitation is inadequate. It is necessary to make in-depth exploration in the relevant guidelines and expert consensus to formulate standardized early rehabilitation diagnosis and treatment procedures and standards for mechanically ventilated children. In the paper, a structured graded lung rehabilitation program is constructed for children with mechanical ventilation to improve their respiratory function,… More >

Dongkai Shen^1,2,+, Qian Zhang¹, Yixuan Wang^1,*, Huiqing Ge^3,*, Zujin Luo^4,+

CMES-Computer Modeling in Engineering & Sciences, Vol.114, No.2, pp. 117-139, 2018, DOI:10.3970/cmes.2018.114.117

Abstract A pressure controlled mechanical ventilator with an automatic secretion clearance function can improve secretion clearance safely and efficiently. Studies on secretion clearance by pressure controlled systems show that these are suited for clinical applications. However, these studies are based on a single lung electric model and neglect the coupling between the two lungs. The research methods applied are too complex for the analysis of a multi-parameter system. In order to understand the functioning of the human respiratory system, this paper develops a dimensionless mathematical model of double-lung mechanical ventilation system with a secretion clearance function. An experiment is designed to… More >

Ramana M. Pidaparti^∗,†, Kittisak Koombua^∗,‡

Molecular & Cellular Biomechanics, Vol.8, No.2, pp. 149-168, 2011, DOI:10.3970/mcb.2011.008.149

Abstract Better understanding of the stress/strain environment in airway tissues is very important in order to avoid lung injuries for patients undergoing mechanical ventilation for treatment of respiratory problems. Airway tissue strains responsible for stressing the lung's fiber network and rupturing the lung due to compliant airways are very difficult to measure experimentally. A computational model that incorporates the heterogeneity of the airways was developed to study the effects of airway tissue material properties on strain distributions within each layer of the airway wall. The geometry and boundary conditions of the tissue strain analysis were obtained from the organ-level analysis model.… More >

Kittisak Koombua^*, Ramana M. Pidaparti^∗,†,‡, P. Worth Longest^∗,‡, Kevin R. Ward^‡,§

Molecular & Cellular Biomechanics, Vol.6, No.4, pp. 203-216, 2009, DOI:10.3970/mcb.2009.006.203

Abstract Without proper knowledge of mechanical ventilation effects, physicians can aggravate an existing lung injury. A better understanding of the interaction between airflow and airway tissue during mechanical ventilation will be helpful to physicians so that they can provide appropriate ventilator parameters for intubated patients. In this study, a computational model incorporating the interactions between airflow and airway walls was developed to investigate the effects of airway tissue flexibility on airway pressure and stress. Two flow rates, 30 and 60 l/min, from mechanical ventilation were considered. The transient waveform was active inhalation with a constant flow rate and passive exhalation. Results… More >