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  • Open Access

    ARTICLE

    Fate of the Fontan connection: Mechanisms of stenosis and management

    Donald J. Hagler1,2, William R. Miranda2, Brielle J. Haggerty1, Jason H. Anderson1, Jonathan N. Johnson1, Frank Cetta1,2, Sameh M. Said1,3, Nathaniel W. Taggart1

    Congenital Heart Disease, Vol.14, No.4, pp. 571-581, 2019, DOI:10.1111/chd.12757

    Abstract Background: Stenosis of the venous connections and conduits is a well‐known late complication of the Fontan procedure. Currently, data on the outcomes of percuta‐ neous intervention for the treatment of extra‐ or intracardiac conduits and lateral tunnel baffles obstruction are limited. In an attempt to better define the nature and severity of the stenosis and the results of catheter interventional management, we reviewed Fontan patients with obstructed extra‐ or intracardiac conduits and lateral tunnel baffles.
    Methods: Retrospective review of all Fontan patients who had cardiac catheteriza‐ tion from January 2002 to October 2018 was performed. Hemodynamic and angio‐ graphic data… More >

  • Open Access

    ARTICLE

    A Numerical Investigation into the Influence of Electrode-Related Parameters on Electroosmotic Mixing and Related Mechanisms

    Chunsheng Wang*, Dongxing Shang

    FDMP-Fluid Dynamics & Materials Processing, Vol.16, No.3, pp. 465-473, 2020, DOI:10.32604/fdmp.2020.08828

    Abstract Electroosmosis is an effective method for liquid mixing. It is associated with the motion of a liquid in a microchannel induced by an applied electric field. In this manuscript, a numerical model is elaborated and implemented for the case of a straight channel with a single electrode pair. In particular, the Navier-Stokes equation combined with the Convection-diffusion and Helmholtz-Smoluchowski equation are used to simulate the resulting flow field. The influence of various electrode parameters on the mixing efficiency and the related mechanisms are investigated. The numerical results show that a pair of eddies are produced alternately by the changing electric… More >

  • Open Access

    REVIEW

    Mechanisms of the Formation and Involuntary Repetition of Trauma-Related Flashback: A Review of Major Theories of PTSD

    Ming Wang1, Jing Liu2,*, Qiwu Sun3,4, Wenzhen Zhu4

    International Journal of Mental Health Promotion, Vol.21, No.3, pp. 81-97, 2019, DOI:10.32604/IJMHP.2019.011010

    Abstract Trauma-related flashback is one of the typical symptoms of patients suffered from posttraumatic stress disorder (PTSD), which intrudes into the body and mind of patients uncontrobaly and repeatedly. Psychodynamic theories of mechanisms of the formation and involuntary repetition of trauma-related flashback establish a foundation for most cognitive theories of PTSD. Cognitive behavioral theories of PTSD, from the initial use of behavioristic principles (e.g., conditioning, alternative learning, generalization, etc.) to explain fear conditioning to the emphasis on the roles of cognitive and behavioral factors (e.g., cognitive model or schema, completion tendency, associative network, data-driven processing, analogue representation, etc.) in the representation… More >

  • Open Access

    ARTICLE

    Effect Mechanisms of Hygrothermal Environments on Failure of Single-Lap and Double-Lap CFRP-Aluminum Bolted Joints

    Meijuan Shan1, 2, Libin Zhao2, *, Wei Huang3, Fengrui Liu2, Jianyu Zhang4, *

    CMES-Computer Modeling in Engineering & Sciences, Vol.123, No.1, pp. 101-127, 2020, DOI:10.32604/cmes.2020.09099

    Abstract The high demands for load-carrying capability and structural efficiency of composite-metal bolted joints trigger in-depth investigations on failure mechanisms of the joints in hygrothermal environments. However, few studies have been presented to exhaustively reveal hygrothermal effects on the failure of CFRP-metal bolted joints, which differ from CFRP-CFRP or metal-metal bolted joints because of the remarkably different material properties of CFRPs and metals. In this paper, hygrothermal effects on tensile failures of single-lap and double-lap CFRP-aluminum bolted joints were experimentally and numerically investigated. A novel numerical model, in which a hygrothermal-included progressive damage model of composites was established and elastic-plastic models… More >

  • Open Access

    ARTICLE

    Thyme oil and thymol abrogate doxorubicin-induced nephrotoxicity and cardiotoxicity in Wistar rats via repression of oxidative stress and enhancement of antioxidant defense mechanisms

    Osama M. AHMED1,*, Sanaa R. GALALY2, Mai RASLAN3, Mennah-Allah M. A. MOSTAFA1,*

    BIOCELL, Vol.44, No.1, pp. 41-53, 2020, DOI:10.32604/biocell.2020.08157

    Abstract This study aimed to assess the preventive effects of thyme oil and thymol on doxorubicin (DOX)-induced renotoxicity, cardiotoxicity, and oxidative stress in Wistar rats. Thyme oil was subjected to GC-MS analysis, which indicated that thymol was the major constituent representing 33.896%. Rats intraperitoneally injected with DOX at a dose of 2 mg/kg b.w./one per week for 7 weeks were co-treated with thyme oil and its major constituent, thymol, at doses 250 and 100 mg/kg b.w./every other day, respectively, by oral gavage for the same period. Thyme oil and thymol markedly ameliorated the raised levels of serum urea, uric acid, and… More >

  • Open Access

    ARTICLE

    Orientation on the Mechanistics of Electron-Transfer on Oxidation of Chondroitin-4-Sulfate as Sustainable Sulfated Polysaccharide by Permanganate Ion in Aqueous Perchlorate Solutions

    Refat Hassan1,*, Hideo Takagi2, Samia Ibrahim3

    Journal of Renewable Materials, Vol.8, No.2, pp. 205-218, 2020, DOI:10.32604/jrm.2020.08530

    Abstract A spectrophotometric investigation of oxidation of chondroitin-4-sulfate (CS) as a sustainable and biodegradable sulfated macromolecule by oxyanion permanganate ion as multi-equivalent oxidant in acid perchlorate solutions at a constant ionic strength of 2.0 mol dm-3 has been studied. The experimental results on the influence of the concentration of the reactants the reaction rates revealed first-order dependence in MnO4 , fractional second-order in [CS] and fractional first-order with respect to the hydrogen ion concentration. The hydrogen acid concentration dependence of the rate constants indicated that the oxidation rates were increased with increasing the acid concentration which means that the oxidation reaction… More >

  • Open Access

    ARTICLE

    A Novel Bidirectional LSTM and Attention Mechanism Based Neural Network for Answer Selection in Community Question Answering

    Bo Zhang1, Haowen Wang1, #, Longquan Jiang1, Shuhan Yuan2, Meizi Li1, *

    CMC-Computers, Materials & Continua, Vol.62, No.3, pp. 1273-1288, 2020, DOI:10.32604/cmc.2020.07269

    Abstract Deep learning models have been shown to have great advantages in answer selection tasks. The existing models, which employ encoder-decoder recurrent neural network (RNN), have been demonstrated to be effective. However, the traditional RNN-based models still suffer from limitations such as 1) high-dimensional data representation in natural language processing and 2) biased attentive weights for subsequent words in traditional time series models. In this study, a new answer selection model is proposed based on the Bidirectional Long Short-Term Memory (Bi-LSTM) and attention mechanism. The proposed model is able to generate the more effective question-answer pair representation. Experiments on a question… More >

  • Open Access

    ARTICLE

    Mechanisms involved in the cytotoxic effects of berberine on human colon cancer HCT-8 cells

    LI-NA XU1#, BI-NAN LU2#, MING-MING HU1, YOU-WEI XU1, XU HAN1, YAN QI1, JIN-YONG PENG1,3*

    BIOCELL, Vol.36, No.3, pp. 113-120, 2012, DOI:10.32604/biocell.2012.36.113

    Abstract Berberine, a constituent of some traditional Chinese medicinal plants, has been reported to have cytotoxicity effects on different human cancer cell lines. There is no available information about the effects and mechanism of action of berberine on human colon cancer cell line HCT-8. In this paper, the cytotoxicity of berberine on HCT-8 cancer cells was investigated by MTT assay, fluorescence microscopy and flow cytometry analysis. Our data revealed that berberine could significantly inhibit the growth of HCT-8 cells in a dose- and time-dependent manner. Morphology of apoptotic cells was studied with acridine orange/ ethidium bromide staining. The concentrations of lactate… More >

  • Open Access

    REVIEW

    A Review of Structural Health Monitoring Techniques as Applied to Composite Structures

    Amafabia, Daerefa-a Mitsheal1, Montalvão, Diogo2, David-West, Opukuro1, Haritos, George1

    Structural Durability & Health Monitoring, Vol.11, No.2, pp. 91-147, 2017, DOI:10.3970/sdhm.2017.011.091

    Abstract Structural Health Monitoring (SHM) is the process of collecting, interpreting and analysing data from structures in order to determine its health status and the remaining life span. Composite materials have been extensively use in recent years in several industries with the aim at reducing the total weight of structures while improving their mechanical properties. However, composite materials are prone to develop damage when subjected to low to medium impacts (i.e. 1-10 m/s and 11-30 m/s respectively). Hence, the need to use SHM techniques to detect damage at the incipient initiation in composite materials is of high importance. Despite the availability… More >

  • Open Access

    ARTICLE

    A New Method for Maintenance Management Employing Principal Component Analysis

    Fausto Pedro García Márquez1

    Structural Durability & Health Monitoring, Vol.6, No.2, pp. 89-100, 2010, DOI:10.3970/sdhm.2010.006.089

    Abstract This paper presents a simple graphic method for detecting and classifying faults in point mechanisms based on the study of some statistical parameters of the force and current signals of the point machine. Principal Components Analysis (PCA) employed in order to reduce the number of these parameters. PCA is utilised in this paper for modifying the parameter dataset, and reducing the coordinate system by linear transformation. It is then possible to plot the new coordinate system in 2 or 3 dimensions, where the faults can be detected and identified. In this work most of the faults could be detected, but… More >

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