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  • Open Access


    In Vitro Propagation and Artificial Seed Production of Fritillaria cirrhosa D. Don, an Endangered Medicinal Plant

    Qian Tao, Guiqi Han, Bujin Ma, Hongmei Jia, Can Zhao, Wenshang Li, Zhuyun Yan*

    Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1297-1310, 2024, DOI:10.32604/phyton.2024.051923

    Abstract Fritillaria cirrhosa D. Don (Liliaceae) is an endangered perennial bulbous plant and its dry bulb is a valuable medicinal material with antitussive and expectorant effects. Nevertheless, lack of resources and expensive prices make it difficult to meet clinical needs. This study presents a regeneration system aimed at overcoming the challenge of inadequate supply in F. cirrhosa, focusing on: (1) callus induction, (2) bulblets and adventitious bud induction, and (3) artificial seed production. Callus development was achieved in 84.93% on Murashige and Skoog (MS) medium fortified with 1.0 mg·L picloram. The optimal medium for callus differentiation into regenerated… More >

  • Open Access


    Microbial Fertilizer: A Sustainable Strategy for Medicinal Plants Production

    Chuang Liu1,2, Jing Xie2, Hao Liu2, Can Zhong2, Gen Pan2, Shuihan Zhang2, Jian Jin2,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1221-1236, 2024, DOI:10.32604/phyton.2024.050759

    Abstract Medicinal plants have aroused considerable interest as an alternative to chemical drugs due to the beneficial effects of their active secondary metabolites. However, the extensive use of chemical fertilizers and pesticides in pursuit of yield has caused serious pollution to the environment, which is not conducive to sustainable development in the field of medicinal plants. Microbial fertilizers are a type of “green fertilizer” containing specific microorganisms that can improve the soil microbial structure, enhance plant resistance to biological and abiotic stresses, and increase the yield of medicinal plants. The root exudates of medicinal plants attract… More >

  • Open Access


    A perspective review on the biosynthesis of plant-based secondary metabolites and their application as potent drugs


    BIOCELL, Vol.48, No.4, pp. 541-557, 2024, DOI:10.32604/biocell.2023.029031

    Abstract Many phytochemicals and their derived metabolites produced by plants are extensively employed in commercial goods, pharmaceutical products as well as in the environmental and medical fields. However, these secondary metabolites obtained from plants are in low amounts, and it is difficult to synthesize them at the industrial level. Despite these challenges, they may be utilized for a variety of medicinal products that are either available in the market or are being researched and tested. Secondary metabolites are complex compounds that exhibit chirality. Further, under controlled conditions with elicitors, desired secondary metabolites may be produced from More > Graphic Abstract

    A perspective review on the biosynthesis of plant-based secondary metabolites and their application as potent drugs

  • Open Access


    Effects of Flowering Mode and Pollinator Sharing on Reproductive Success in Natural Hybrid of Two Epimedium (Berberidaceae) Species

    Lanying Chen1,2, Qiumei Quan3,*, Yunxiang Li3

    Phyton-International Journal of Experimental Botany, Vol.93, No.3, pp. 551-566, 2024, DOI:10.32604/phyton.2024.048103

    Abstract Mediated by pollen flow, natural hybridization is deemed a crucial factor that propels speciation in floral plants. Despite the fact that the diversity of Epimedium species is concentrated mainly in Southwestern China, the potential impact of interspecific pollination on natural hybridization has yet to be empirically scrutinized. To explore this, we studied the flowering period and the visitors of flowers in three frequently overlapping Epimedium species at Jinchengshan National Forest Park, located in Nanchong, Sichuan Province. Additionally, we performed a series of pollination experiments to examine breeding systems and hybrid compatibility. Morphologically, Epimedium pubescens and Epimedium wushanense are… More >

  • Open Access


    Arbuscular Mycorrhizal Fungi Alleviates Salt-Alkali Stress Demage on Syneilesis aconitifolia

    Linlin Fang, Jiamei Xu, Chunxue Yang*

    Phyton-International Journal of Experimental Botany, Vol.92, No.12, pp. 3195-3209, 2023, DOI:10.32604/phyton.2023.043049

    Abstract Syneilesis aconitifolia is a potential ground cover and decorative material in gardens, which exhibits a strong salt-alkali tolerance, and also has medicinal value. In this study, the arbuscular mycorrhizal (AM) fungi community in the soil surrounding S. aconitifolia roots in the Songnen saline-alkali grassland was used as the inoculation medium for a pot cultivation experiment. After normal culture for 90 days, NaCl and NaHCO3 solutions were applied to subject plants to salt or alkali stress. Solution concentrations of 50, 100, and 200 mmol/L were applied for 10 days, and mycorrhizal colonization, biomass, relative water content (RWC), chlorophyll concentration,… More >

  • Open Access


    Study of molecular mechanisms underlying the medicinal plant Tripterygium wilfordii-derived compound celastrol in treating diabetic nephropathy based on network pharmacology and molecular docking


    BIOCELL, Vol.47, No.8, pp. 1853-1867, 2023, DOI:10.32604/biocell.2023.029353

    Abstract Background: Diabetic nephropathy (DN) is a serious complication of diabetes with rising prevalence worldwide. We aimed to explore the anti-DN mechanisms of the compound celastrol derived from the medicinal plant Tripterygium wilfordii. Methods: Celastrol-related targets were obtained from Herbal Ingredients’ Targets (HIT) and GeneCards databases. DN-related targets were retrieved from GeneCards, DisGeNET, and Therapeutic Targets Database (TTD). A Protein-protein interaction (PPI) network was established using the Search Tool for the Retrieval of Interacting Genes (STRING) database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed using ClusterProfiler. The cytoHubba plugin… More > Graphic Abstract

    Study of molecular mechanisms underlying the medicinal plant <i>Tripterygium wilfordii</i>-derived compound celastrol in treating diabetic nephropathy based on network pharmacology and molecular docking

  • Open Access


    Development of micro/nanostructured‒based biomaterials with biomedical applications


    BIOCELL, Vol.47, No.8, pp. 1743-1755, 2023, DOI:10.32604/biocell.2023.027154

    Abstract Natural biomaterials are now frequently used to build biocarrier systems, which can carry medications and biomolecules to a target region and achieve a desired therapeutic effect. Biomaterials and polymers are of great importance in the synthesis of nanomaterials. The recent studies have tended to use these materials because they are easily obtained from natural sources such as fungi, algae, bacteria, and medicinal plants. They are also biodegradable, compatible with neighborhoods, and non-toxic. Natural biomaterials and polymers are chemically changed when they are linked by cross linking agents with other polymers to create scaffolds, matrices, composites, More >

  • Open Access


    Micropropagation of Daylily (Hemerocallis fulva) from Crown-Tip Explants and Assessment of Somaclonal Variation of in Vitro-Propagated Plants Using SCoT Markers

    Esraa E. Shalan1, Said S. Soliman1, Ahmed A. Mahmoud1, Jameel M. Al-Khayri2,*, Salha M. ALshamrani3, Fatmah A. Safhi4, Areej S. Jalal4, Diaa Abd El-Moneim5, Abdallah A. Hassanin1,*

    Phyton-International Journal of Experimental Botany, Vol.92, No.7, pp. 2183-2196, 2023, DOI:10.32604/phyton.2023.028537

    Abstract Determination of the somaclonal variation of in vitro-propagated plants is crucial to determine the appropriate micropropagation protocol and growth regulators for commercial scale multiplication. In this research, nine multiplication media (MM) augmented with different concentrations of 6-benzyl adenine (BA), Kinetin (Kin), and Thidiazuron (TDZ), Three rooting media (RM) supplemented with three levels of α-naphthalene acetic acid (NAA) and three types of soil mixtures (v/v); Coco peat/Vermiculite/Sand (CVS), Peat moss/Perlite/Sand (PPS) and Peat moss/Perlite (PP) were used in the micropropagation protocol of daylily plants. MM2 showed the maximum shoot length and the number of leaves, while MM9… More >

  • Open Access


    Therapeutic targets and signal transduction mechanisms of medicinal plant formula Gancao Xiexin decoction against ulcerative colitis: A network pharmacological study


    BIOCELL, Vol.47, No.6, pp. 1329-1344, 2023, DOI:10.32604/biocell.2023.028381

    Abstract Background: Ulcerative colitis (UC) is a chronic disease that often presents with abdominal pain, diarrhea, hematochezia, and significant morbidity. Gancao Xiexin decoction (GXD), a traditional Chinese medicine, has been applied for the clinical treatment of UC, while its action mechanisms are unclear. Methods: The active ingredients and their targets of GXD, and UC-related targets, were derived from public databases. Protein-protein interaction, Gene Ontology (GO), and the Kyoto Encyclopedia of Genes and Genomes (KEGG) were used to analyze the important active compounds, key targets, and signaling pathways. Then, molecular docking and animal experiments were performed to verify… More >

  • Open Access


    Network pharmacology and molecular docking identify mechanisms of medicinal plant-derived 1,2,3,4,6-penta-O-galloyl-beta-D-glucose treating gastric cancer


    BIOCELL, Vol.47, No.5, pp. 977-989, 2023, DOI:10.32604/biocell.2023.028402

    Abstract Background: 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) is a natural polyphenolic compound derived from multiple medicinal plants with favorable anticancer activity. Methods: In this study, the mechanisms of PGG against gastric cancer were explored through network pharmacology and molecular docking. First, the targets of PGG were searched in the Herbal Ingredients’ Targets (HIT), Similarity Ensemble Approach (SEA), and Super-PRED databases. The potential targets related to gastric cancer were predicted from the Human Gene Database (GeneCards) and DisGeNET databases. The intersecting targets of PGG and gastric cancer were obtained by Venn diagram and then subjected to protein-protein interaction analysis to screen… More >

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