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  • Open Access


    Biological characteristics and clinical management of uveal and conjunctival melanoma


    Oncology Research, Vol.32, No.8, pp. 1265-1285, 2024, DOI:10.32604/or.2024.048437

    Abstract Uveal and conjunctival melanomas are relatively rare tumors; nonetheless, they pose a significant risk of mortality for a large number of affected individuals. The pathogenesis of melanoma at different sites is very similar, however, the prognosis for patients with ocular melanoma remains unfavourable, primarily due to its distinctive genetic profile and tumor microenvironment. Regardless of considerable advances in understanding the genetic characteristics and biological behaviour, the treatment of uveal and conjunctival melanoma remains a formidable challenge. To enhance the prospect of success, collaborative efforts involving medical professionals and researchers in the fields of ocular biology… More > Graphic Abstract

    Biological characteristics and clinical management of uveal and conjunctival melanoma

  • Open Access


    Examining the In Vitro Efficacy of the IAP Antagonist Birinapant as a Single Agent or in Combination With Dacarbazine to Induce Melanoma Cell Death

    Vesna Vetma*†‡, Jan Rožanc§, Emilie M. Charles*†, Christian T. Hellwig*†‡¶, Leonidas G. Alexopoulos§#, Markus Rehm*†‡#

    Oncology Research, Vol.25, No.9, pp. 1489-1494, 2017, DOI:10.3727/096504017X14897145996933

    Abstract Antagonists of inhibitors of apoptosis proteins (IAPs), alone or in combination with genotoxic therapeutics, have been shown to efficiently induce cell death in various solid tumors. The IAP antagonist birinapant is currently being tested in phase II clinical trials. We herein aimed to investigate the antitumor efficacy of dacarbazine in vitro, both as a single agent and in combination with birinapant, in melanoma cell lines. Covering clinically relevant drug concentration ranges, we conducted a total of 5,400 measurements in a panel of 12 human melanoma cell lines representing different stages of disease progression. Surprisingly, functionally More >

  • Open Access


    MicroRNA-342 Prohibits Proliferation and Invasion of Melanoma Cells by Directly Targeting Zinc-Finger E-Box-Binding Homeobox 1

    Quan Shi*†, Qi He*, Jing Wei*

    Oncology Research, Vol.26, No.9, pp. 1447-1455, 2018, DOI:10.3727/096504018X15193823766141

    Abstract As documented in numerous studies, microRNAs (miRNAs) play key roles in various biological processes associated with melanoma occurrence and development. In this study, we found that miRNA-342 (miR-342) was significantly downregulated in melanoma tissues and cell lines. Additionally, the ectopic expression of miR-342 prohibited the cell proliferation and invasion of melanoma. Moreover, zinc-finger E-box-binding homeobox 1 (ZEB1) was identified as a direct target gene of miR-342 in melanoma. Similar with the results induced by miR-342 overexpression, ZEB1 knockdown attenuated cell proliferation and invasion in melanoma. Furthermore, the restoration of ZEB1 expression reversed the suppressive effects More >

  • Open Access


    MicroRNA-331 Inhibits Proliferation and Invasion of Melanoma Cells by Targeting Astrocyte-Elevated Gene-1

    Li Chen, Guozhang Ma, Xiaohui Cao, Xiaoxia An, Xiguang Liu

    Oncology Research, Vol.26, No.9, pp. 1429-1437, 2018, DOI:10.3727/096504018X15186047251584

    Abstract Melanoma is characterized by aggressive invasion, early metastasis, and resistance to existing chemotherapeutic agents. Accumulated studies have reported that microRNA (miRNA) is a potentially robust molecular tool for developing future therapeutic technologies. Therefore, examining the expression patterns, biological roles, and associated mechanisms of cancer-related miRNAs in melanoma is essential for developing novel therapeutic targets for patients with this disease. In this study, miRNA-331 (miR-331) was underexpressed in melanoma tissues and cell lines. Functional assays revealed that the enforced expression of miR-331 inhibited cell proliferation and invasion. In addition, astrocyte-elevated gene-1 (AEG-1) was identified as a More >

  • Open Access


    Long Noncoding RNA PVT1 Promotes Melanoma Progression via Endogenous Sponging miR-26b

    Bao-Juan Wang*, Hong-Wei Ding, Guo-An Ma

    Oncology Research, Vol.26, No.5, pp. 675-681, 2018, DOI:10.3727/096504017X14920318811730

    Abstract Melanoma is an extremely aggressive malignant skin tumor with a high mortality. Various long noncoding RNAs (lncRNAs) have been reported to be associated with the oncogenesis of melanoma. The purposes of this study were to investigate the potential role of lncRNA PVT1 in melanoma progression and to explore its possible mechanisms. A total of 35 patients who were diagnosed with malignant melanoma were enrolled in this study. Expression of PVT1 was significantly upregulated in melanoma tissue and was associated with a poor prognosis. Loss-of-function experiments showed that PVT1 knockdown markedly suppressed the proliferation activity, induced More >

  • Open Access


    [ARTICLE WITHDRAWN] MicroRNA-539 Inhibits the Epithelial‐Mesenchymal Transition of Esophageal Cancer Cells by Twist-Related Protein 1-Mediated Modulation of Melanoma-Associated Antigen A4

    Cao Zhili 1, Zheng Xiang2, Cao Lei1, Liang Naixin1

    Oncology Research, Vol.26, No.4, pp. 529-536, 2018, DOI:10.3727/096504017X14972679378357

    Abstract This article has been withdrawn at the request of the author in December 2020. STATEMENT FOR WITHDRAWAL OF MANUSCRIPT FROM ONCOLOGY RESEARCH Dear Editors, I am Dr. Naixin Liang. For some scientific reasons, my team and I are very sorry to apply to withdraw the manuscript "MicroRNA-539 Inhibits the Epithelial-Mesenchymal Transition of Esophageal Cancer Cells By Twist-Related Protein 1-Mediated Modulation of Melanoma Associated Antigen A4 (MAGEA4)". DOI: 10.3727/096504017 x14972679378357 Because of COVID-19, the lab we worked together was no longer functioning and closed. When reviewing the data of the paper completed in cooperation with the… More >

  • Open Access


    The lncRNA CCAT1 Upregulates Proliferation and Invasion in Melanoma Cells via Suppressing miR-33a

    Li Lv*, Jian-Qin Jia*, Jin Chen

    Oncology Research, Vol.26, No.2, pp. 201-208, 2018, DOI:10.3727/096504017X14920318811749

    Abstract It is increasingly evident that various long noncoding RNAs (lncRNAs) participate in the tumorigenesis of multiple tumors, including melanoma. lncRNAs have been validated as oncogenic factors in various tumors; however, the potential regulatory mechanism of CCAT1 in melanoma is still unclear. The purpose of this study was to investigate the regulation of CCAT1 on melanoma genesis. The expression of CCAT1 in melanoma tissue and cell lines was measured using qRT-PCR. Interference oligonucleotide or mimic sequences were applied to up- or downregulate RNA expression. CCK-8 and colony formation assays were performed to detect the proliferation capability.… More >

  • Open Access


    Circ_0053943 complexed with IGF2BP3 drives uveal melanoma progression via regulating N6-methyladenosine modification of Epidermal growth factor receptor


    Oncology Research, Vol.32, No.5, pp. 983-998, 2024, DOI:10.32604/or.2024.045972

    Abstract Numerous studies have characterized the critical role of circular RNAs (circRNAs) as regulatory factors in the progression of multiple cancers. However, the biological functions of circRNAs and their underlying molecular mechanisms in the progression of uveal melanoma (UM) remain enigmatic. In this study, we identified a novel circRNA, circ_0053943, through re-analysis of UM microarray data and quantitative RT-PCR. Circ_0053943 was found to be upregulated in UM and to promote the proliferation and metastatic ability of UM cells in both in vitro and in vivo settings. Mechanistically, circ_0053943 was observed to bind to the KH1 and KH2 domains of insulin-like… More > Graphic Abstract

    <i>Circ_0053943</i> complexed with IGF2BP3 drives uveal melanoma progression via regulating N6-methyladenosine modification of <i>Epidermal growth factor receptor</i>

  • Open Access


    Stem cell technology for antitumor drug loading and delivery in oncology


    Oncology Research, Vol.32, No.3, pp. 433-437, 2024, DOI:10.32604/or.2023.046497

    Abstract The main aim of antineoplastic treatment is to maximize patient benefit by augmenting the drug accumulation within affected organs and tissues, thus incrementing drug effects and, at the same time, reducing the damage of non-involved tissues to cytotoxic agents. Mesenchymal stromal cells (MSC) represent a group of undifferentiated multipotent cells presenting wide self-renewal features and the capacity to differentiate into an assortment of mesenchymal family cells. During the last year, they have been proposed as natural carriers for the selective release of antitumor drugs to malignant cells, thus optimizing cytotoxic action on cancer cells, while More >

  • Open Access


    Low-molecular-weight fucoidan inhibits the proliferation of melanoma via Bcl-2 phosphorylation and PTEN/AKT pathway


    Oncology Research, Vol.32, No.2, pp. 273-282, 2024, DOI:10.32604/or.2023.044362

    Abstract Fucoidan, a sulfate polysaccharide obtained from brown seaweed, has various bioactive properties, including anti-inflammatory, anti-cancer, anti-viral, anti-oxidant, anti-coagulant, anti-thrombotic, anti-angiogenic, and anti-Helicobacter pylori properties. However, the effects of low-molecular-weight fucoidan (LMW-F) on melanoma cell lines and three dimensional (3D) cell culture models are not well understood. This study aimed to investigate the effects of LMW-F on A375 human melanoma cells and cryopreserved biospecimens derived from patients with advanced melanoma. Ultrasonic wave was used to fragment fucoidan derived from Fucus vesiculosus into smaller LMW-F. MTT and live/dead assays showed that LMW-F inhibited cell proliferation in both A375 cells More >

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