Xiaoting Wei, Lili Mao, Zhihong Chi, Xinan Sheng, Chuanliang Cui, Yan Kong, Jie Dai, Xuan Wang, Siming Li, Bixia Tang, Bin Lian, Xieqiao Yan, Xue Bai, Li Zhou, Jun Guo, Lu Si

Oncology Research, Vol.27, No.4, pp. 495-501, 2019, DOI:10.3727/096504018X15331163433914

Abstract Melanoma is an aggressive malignancy with a poor prognosis. Current studies show that imatinib treatment is a promising approach in treating advanced melanoma patients harboring c-Kit mutations or amplifications. We retrospectively analyzed the clinical medical records of 78 patients with metastatic melanoma harboring c-Kit mutations or amplifications. These patients were treated with imatinib at a dose of 400 mg/day continuously unless intolerable toxicities or disease progression occurred. Endpoints for exploration included overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and disease of control rate (DCR). The median OS and PFS of all patients were 13.1 and 4.2 months,… More >

Ting La^*†, Lei Jin^*‡, Xiao Ying Liu^*, Ze Hua Song^*, Margaret Farrelly^†, Yu Chen Feng^†, Xu Guang Yan^†, Yuan Yuan Zhang^*,† Rick F. Thorne^*,*§ Xu Dong Zhang^*†, Liu Teng^*

Oncology Research, Vol.28, No.4, pp. 385-398, 2020, DOI:10.3727/096504020X15861709922491

Abstract The deubiquitinase cylindromatosis (CYLD) functions as a tumor suppressor inhibiting cell proliferation in many cancer types including melanoma. Here we present evidence that a proportion of melanoma cells are nonetheless addicted to CYLD for survival. The expression levels of CYLD varied widely in melanoma cell lines and melanomas in vivo, with a subset of melanoma cell lines and melanomas displaying even higher levels of CYLD than melanocyte lines and nevi, respectively. Strikingly, although short hairpin RNA (shRNA) knockdown of CYLD promoted, as anticipated, cell proliferation in some melanoma cell lines, it reduced cell viability in a fraction of melanoma cell… More >

Elena Andreucci^*1, Anna Laurenzana^*, Silvia Peppicelli^*, Alessio Biagioni^*, Francesca Margheri^*, Jessica Ruzzolini^*, Francesca Bianchini^*, Gabriella Fibbi^*, Mario Del Rosso^*†, Chiara Nediani^*, Simona Serratì^‡, Livia Fucci^§, Michele Guida^¶, Lido Calorini^*†1

Oncology Research, Vol.28, No.9, pp. 873-884, 2020, DOI:10.3727/096504021X16273798026651

Abstract Malignant melanoma is a highly aggressive skin cancer characterized by an elevated grade of tumor cell plasticity. Such plasticity allows adaptation of melanoma cells to different hostile conditions and guarantees tumor survival and disease progression, including aggressive features such as drug resistance. Indeed, almost 50% of melanoma rapidly develop resistance to the BRAFV600E inhibitor vemurafenib, with fast tumor dissemination, a devastating consequence for patients’ outcomes. Vasculogenic mimicry (VM), the ability of cancer cells to organize themselves in perfused vascular-like channels, might sustain tumor spread by providing vemurafenibresistant cancer cells with supplementary ways to enter into circulation and disseminate. Thus, this… More >

Zhili Cao^*1, Xiang Zheng^†1, Lei Cao^*, Naixin Liang^*

Oncology Research, Vol.28, No.7-8, pp. 831-831, 2020, DOI:10.3727/096504020X16231418632584

Abstract This article has no abstract. More >

Ismail Bozkurt^1,*, Baris Yasar¹, Mehmet Baran Uslu², Nazan Bozdogan³

Oncologie, Vol.24, No.1, pp. 163-171, 2022, DOI:10.32604/oncologie.2022.019263

Abstract Malignant melanoma caused by malignant transformation of melanocytes is associated with high mortality and is difficult to manage. Metastasis is not uncommon (up to 31% of all cases) and is closely associated with a poor prognosis. Although rare (4–5%), extracutaneous melanoma has been reported; however, primary malignant melanoma of the sacrum is extremely rare (only three case reports to date). Here, we present a 51-year-old patient who underwent surgical treatment for a lesion of the spinal canal and associated bony structures; extensive aggressive resection was required. She underwent partial sacrectomy and lumbo-iliac fixation (to maintain spinal stability). Pathology revealed malignant… More >

Fikret Yalcinkaya^*, Ali Erbas

Intelligent Automation & Soft Computing, Vol.33, No.3, pp. 1961-1977, 2022, DOI:10.32604/iasc.2022.024961

Abstract Early stage melanoma detection (ESMD) is crucial as late detection kills. Computer aided diagnosis systems (CADS) integrated with high level algorithms are major tools capable of ESMD with high degree of accuracy, specificity, and sensitivity. CADS use the image and the information within the pixels of the image. Pixels’ characteristics and orientations determine the colour and shapes of the images as the pixels and associated environment are closely interrelated with the lesion. CADS integrated with Convolutional Neural Networks (CNN) specifically play a major role for ESMD with high degree of accuracy. The proposed system has two steps to produce high… More >

Saad Awadh Alanazi^*

CMC-Computers, Materials & Continua, Vol.72, No.1, pp. 37-55, 2022, DOI:10.32604/cmc.2022.020118

Abstract Melanoma, also called malignant melanoma, is a form of skin cancer triggered by an abnormal proliferation of the pigment-producing cells, which give the skin its color. Melanoma is one of the skin diseases, which is exceptionally and globally dangerous, Skin lesions are considered to be a serious disease. Dermoscopy-based early recognition and detection procedure is fundamental for melanoma treatment. Early detection of melanoma using dermoscopy images improves survival rates significantly. At the same time, well-experienced dermatologists dominate the precision of diagnosis. However, precise melanoma recognition is incredibly hard due to several factors: low contrast between lesions and surrounding skin, visual… More >

JUAN CARLOS STOCKERT^1,2,*, ALFONSO BLÁZQUEZ-CASTRO³

BIOCELL, Vol.46, No.6, pp. 1391-1415, 2022, DOI:10.32604/biocell.2022.019493

Abstract

Melanins represent one of the most ancient and important group of natural macromolecular pigments. They have multiple biological roles in almost all organisms across the Phyla, examples being photoprotection, anti-oxidative action, radical scavenger activity, and heavy metal removal. From the biomedical point of view, melanocytes are involved in the origin of melanoma tumors, and the main therapeutic advances for their treatment have been revised in Part 1 of this review. The chemical structure of eumelanin is a biological concern of great importance, and therefore, exploring theoretical molecular models and synthesis mechanisms will be here described, as well as molecular orbital… More >

Saeed Iqbal^1,*, Adnan N. Qureshi¹, Ghulam Mustafa²

CMC-Computers, Materials & Continua, Vol.71, No.3, pp. 4915-4939, 2022, DOI:10.32604/cmc.2022.023178

Abstract Skin cancer (melanoma) is one of the most aggressive of the cancers and the prevalence has significantly increased due to increased exposure to ultraviolet radiation. Therefore, timely detection and management of the lesion is a critical consideration in order to improve lifestyle and reduce mortality. To this end, we have designed, implemented and analyzed a hybrid approach entailing convolutional neural networks (CNN) and local binary patterns (LBP). The experiments have been performed on publicly accessible datasets ISIC 2017, 2018 and 2019 (HAM10000) with data augmentation for in-distribution generalization. As a novel contribution, the CNN architecture is enhanced with an intelligible… More >

Tanzila Saba¹, Rabia Javed^2,3, Mohd Shafry Mohd Rahim², Amjad Rehman^1,*, Saeed Ali Bahaj⁴

CMC-Computers, Materials & Continua, Vol.71, No.3, pp. 6219-6237, 2022, DOI:10.32604/cmc.2022.020865

Abstract The Internet of Medical Things (IoMT) and cloud-based healthcare applications, services are beneficial for better decision-making in recent years. Melanoma is a deadly cancer with a higher mortality rate than other skin cancer types such as basal cell, squamous cell, and Merkel cell. However, detection and treatment at an early stage can result in a higher chance of survival. The classical methods of detection are expensive and labor-intensive. Also, they rely on a trained practitioner's level, and the availability of the needed equipment is essential for the early detection of Melanoma. The current improvement in computer-aided systems is providing very… More >