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  • Open Access

    ARTICLE

    MicroRNA-152 Acts as a Tumor Suppressor MicroRNA by Inhibiting Krüppel-Like Factor 5 in Human Cervical Cancer

    Haiyan Zhang*†, Yanxia Lu, Surong Wang, Xiugui Sheng§, Shiqian Zhang*

    Oncology Research, Vol.27, No.3, pp. 335-340, 2019, DOI:10.3727/096504018X15252202178408

    Abstract Aberrant expression of microRNA-152 (miR-152) is frequently observed in human cancers including ovarian cancer, breast cancer, prostate cancer, and gastric cancer. However, its expression and functional role in cervical cancer (CC) are poorly understood. Also, the association between miR-152 and Krüppel-like factor 5 (KLF5) expression in CC remains unclear. In this study, analyzing the expression of miR-152 by quantitative real-time PCR (qRT-PCR) revealed it was sharply reduced in CC tissues and cell lines. In addition, the negative correlation of miR-152 expression and KLF5 expression was observed. The dual-luciferase reporter assay validated that KLF5 was a More >

  • Open Access

    ARTICLE

    Expression and Clinical Significance of miR-152 and CYFRA21-1 in Ovarian Cancer Tissues

    Guiping Chen*, Tiantian Xie, Haibo Chen, Lijuan Chen

    Oncologie, Vol.22, No.2, pp. 83-93, 2020, DOI:10.32604/oncologie.2020.012491

    Abstract To investigate the expression and clinical significance of miR-152 and CYFRA21-1 in ovarian cancer (OC) tissues. Seventy-four OC patients diagnosed in our hospital from March 2016 to April 2019 (research group, RG) and 30 patients with benign ovarian tumor at the same time (control group, CG) were collected as research objects in this experiment. qRT-PCR and ELISA were used to detect and observe the expression levels of miR-152 in patient tissues and CYFRA21-1 in serum. ROC curves were drawn to analyze the diagnostic value of miR-152 and CYFRA21-1 in OC. The clinicopathological correlation analysis was… More >

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