Lili Zhao*, Yao Zhang*, Jiaoxia Liu*, Wei Yin†, Dan Jin‡, Dandan Wang*, Wei Zhang*
Oncology Research, Vol.27, No.9, pp. 1015-1023, 2019, DOI:10.3727/096504018X15247341491655
Abstract MicroRNAs (miRNAs) are short endogenous noncoding RNAs that frequently play vital roles in many cancer
types. Herein we demonstrated that miR-185 was remarkably downregulated in NSCLC tissues compared with
adjacent normal tissues. A lower level of miR-185 was associated with lymph node metastasis. Functional
assays showed that upregulation of miR-185 inhibited the proliferation, colony formation, and invasion capacities of NSCLC cells in vitro. Furthermore, we found that miR-185 suppressed the epithelial–mesenchymal
transition (EMT) process. Bioinformatics analysis and luciferase reporter gene assays revealed that Kruppellike factor 7 (KLF7) was the target of miR-185. Overexpression of miR-185 reduced the expression of KLF7… More >
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