Hung-Hsiang Wang¹, Chih-Ping Chen^2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 685-709, 2024, DOI:10.32604/cmes.2024.047630

Abstract This paper presents a new method of using a convolutional neural network (CNN) in machine learning to identify brand consistency by product appearance variation. In Experiment 1, we collected fifty mouse devices from the past thirty-five years from a renowned company to build a dataset consisting of product pictures with pre-defined design features of their appearance and functions. Results show that it is a challenge to distinguish periods for the subtle evolution of the mouse devices with such traditional methods as time series analysis and principal component analysis (PCA). In Experiment 2, we applied deep learning to predict the extent… More >

DANPING ZHU^1,#, GUANGMING LIU^1,#, KUAN FENG¹, SUYUN LI¹, DANDAN HU², SIDA YANG^3,*, PEIQING LI^1,*

BIOCELL, Vol.48, No.4, pp. 653-664, 2024, DOI:10.32604/biocell.2024.044856

Abstract Background: During Enterovirus type 71 (EV71) infection, the structural viral protein 1 (VP1) activates endoplasmic reticulum (ER) stress associated with peripheral myelin protein 22 (PMP22) accumulation and induces autophagy. However, the specific mechanism behind this process remains elusive. Methods: In this research, we used the VP1-overexpressing mouse Schwann cells (SCs) models co-transfected with a PMP22 silencing or Autocrine motility factor receptor (AMFR/gp78) overexpressing vector to explore the regulation of gp78 on PMP22 and its relationship with autophagy and apoptosis. Results: The activity of gp78 could be influenced by EV71-VP1, leading to a decrease in the ubiquitination and degradation of PMP22,… More >

DAOLUN YU¹, DEYONG SHE², KAI GE¹, LEI YANG¹, RUINA ZHAN¹, SHAN LU^3,*, YAFEI CAI^4,*

BIOCELL, Vol.48, No.1, pp. 139-147, 2024, DOI:10.32604/biocell.2023.045884

Abstract Background: SMAD family proteins (SMADs) are crucial transcription factors downstream of transforming growth factor beta (TGF-ß)/SMAD signaling pathways that have been reported to play a pivotal role in mammalian reproduction. However, the role of SMAD family member 8 (SMAD8, also known as SMAD9), a member of the SMAD family, in mammalian reproduction remains unclear. Methods: We employed RNA interference techniques to knock down Smad8 expression in mouse granulosa cells (GCs) to investigate the effects of Smad8 on GC growth and steroidogenesis. Results: Our findings revealed a significant decrease in the proliferative capacity and a substantial increase in the apoptosis rate… More >

DANIELLA M. ADAMS¹, KALIE F. BECKERS¹, JULIET P. FLANAGAN¹, VIVIANE C. L. GOMES^1,#, CHIN-CHI LIU¹, JENNY L. SONES^1,2,*

BIOCELL, Vol.47, No.9, pp. 2051-2058, 2023, DOI:10.32604/biocell.2023.029644

Abstract Background: Women with obesity have higher risk of adverse pregnancy outcomes, including preeclampsia (PE). Late-gestational hypertension, aberrant fetoplacental development, and fetal growth restriction (FGR), hallmarks of PE, are observed spontaneously in BPH/5 mice. Similar to obese preeclamptic women, BPH/5 mice have higher visceral white adipose tissue (WAT) and circulating leptin. We hypothesized that attenuation of maternal obesity and serum leptin in pregnant BPH/5 mice will improve fetoplacental development by decreasing hypoxia markers and leptin expression at the maternal-fetal interface. Methods: To test this hypothesis, BPH/5 mice were fed ad libitum (lib) and pair-fed (PF) to C57 ad lib controls beginning… More >

NAN TANG^1,#, YAJING ZHAN^1,#, JIAYAN MAO^2,#, ANKANG YIN¹, WEI WANG^3,*, JUAN WANG^3,*

BIOCELL, Vol.47, No.9, pp. 2009-2026, 2023, DOI:10.32604/biocell.2023.029269

Abstract Non-small cell lung cancer (NSCLC) is a malignant tumor with high incidence worldwide. Triptolide (TP), extracted from Tripterygium wilfordii Hook F, exhibits potent broad-spectrum antitumor activity. Although some mechanisms through which TP inhibits NSCLC are well understood, those that involve ribosomal proteins remain yet to be understood. In this study, the transcriptome and proteome were integrated and analyzed. Our data indicated ribosomal protein L4 (RPL4) to be a core hub protein in the protein-protein interaction network. RPL4 is overexpressed in NSCLC tissues and cells. Transfection with siRPL4 or TP treatment alone arrested the cell cycle in the G1 phase, induced… More > Graphic Abstract

Shin Jin Kang¹, Soo Kyun Kim^2,*

Intelligent Automation & Soft Computing, Vol.35, No.3, pp. 2573-2588, 2023, DOI:10.32604/iasc.2023.029893

Abstract In this paper, we propose an authentication method that use mouse and keystroke dynamics to enhance online privacy and security. The proposed method identifies personalized repeated user interface (UI) sequences by analyzing mouse and keyboard data. To this end, an Apriori algorithm based on the keystroke-level model (KLM) of the human–computer interface domain was used. The proposed system can detect repeated UI sequences based on KLM for authentication in the software. The effectiveness of the proposed method is verified through access testing using commercial applications that require intensive UI interactions. The results show using our cognitive mouse-and-keystroke dynamics system can… More >

B. Kalpana¹, S. Dhanasekaran², T. Abirami³, Ashit Kumar Dutta⁴, Marwa Obayya⁵, Jaber S. Alzahrani⁶, Manar Ahmed Hamza^7,*

Computer Systems Science and Engineering, Vol.44, No.3, pp. 2243-2257, 2023, DOI:10.32604/csse.2023.027129

Abstract Biomedical data classification has become a hot research topic in recent years, thanks to the latest technological advancements made in healthcare. Biomedical data is usually examined by physicians for decision making process in patient treatment. Since manual diagnosis is a tedious and time consuming task, numerous automated models, using Artificial Intelligence (AI) techniques, have been presented so far. With this motivation, the current research work presents a novel Biomedical Data Classification using Cat and Mouse Based Optimizer with AI (BDC-CMBOAI) technique. The aim of the proposed BDC-CMBOAI technique is to determine the occurrence of diseases using biomedical data. Besides, the… More >

Ming Jia^*1, Yulin Xiong^†1, Maoshi Li^*, Qing Mao^*

Oncology Research, Vol.28, No.4, pp. 371-383, 2020, DOI:10.3727/096504020X15853075736554

Abstract Chemotherapy is critical for the treatment of hepatocellular carcinoma (HCC). Despite the proapoptotic effects of corosolic acid (CA) treatment, its underlying mechanism is not completely clear. The aim of this study was to determine the molecular mechanism of CA in HCC treatment. MTT assay was used to determine the IC50 of CA. Immunoprecipitation and immunofluorescence were used to detect the interaction and subcellular localization of Yes-associated protein (YAP) and mouse double minute 2 (MDM2). In addition, in vivo xenotransplantation was performed to assess the effects of CA, YAP, and MDM2 on tumorigenesis. The IC50 of CA was about 40 µM… More >

XINFU FAN^1,2,#, JIE CHEN^3,#, ZONGMENG ZHANG^4,#, FANGHUI CHEN⁵, HAOSEN WANG⁶, YAFEI CAI⁶, JUN LI^7,*

BIOCELL, Vol.46, No.6, pp. 1527-1535, 2022, DOI:10.32604/biocell.2022.018269

Abstract Spinal cord injury (SCI) remains an intractable clinical challenge of neurosurgery, it can be divided into two stages: uncontrollable primary injury induced by mechanical damage and controllable secondary injury regulated by continuous cell death. The apoptosis was the one of most important events in secondary injury, previous studies revealed that excessive endoplasmic reticulum (ER) stress breaks down the homeostasis and triggers apoptosis in the spinal cord. To deter or alleviate the secondary jury, we screen one of fat-soluble compounds, salubrinal, which was an inhibitor of eIF2α dephosphorylation can repair SCI by inhibiting ER stress in mice after SCI. Administration of… More >

XINGYU MEI, ZHOUWEI WU, CHENGZHONG ZHANG, YUE SUN, WEIMIN SHI^*

BIOCELL, Vol.45, No.6, pp. 1551-1559, 2021, DOI:10.32604/biocell.2021.015376

Abstract Vitiligo results in an autoimmune disorder destructing skin pigment cells, melanocytes (Mcs). This study aimed to investigate whether Astragaloside IV (AIV) could efficiently induce differentiation of bone marrow mesenchymal stem cells (BMMSCs) into Mcs. BMMSCs were induced and differentiated into Mcs with 0.1, 0.2, and 0.4 mg/L AIV during 150-day. Morphologic changes of differentiated cells were observed. Levels of some melanocytic specific genes (TRP-1, TRP-2, MART-1, Mitf) were measured with quantitative polymerase chain reaction (qPCR) at 90, 120, and 150 days of induction. After 90-day induction, the differentiated cells with 0.4 mg/L AIV demonstrated the typical morphology of Mcs, positive… More >