El-Sayed M. El-kenawy^1,2, Abdelaziz A. Abdelhamid^3,4, Abdelhameed Ibrahim⁵, Seyedali Mirjalili^6,7, Nima Khodadad⁸, Mona A. Al duailij⁹, Amel Ali Alhussan^9,*, Doaa Sami Khafaga⁹

Computer Systems Science and Engineering, Vol.45, No.2, pp. 1917-1934, 2023, DOI:10.32604/csse.2023.032497

Abstract Metaheuristic optimization algorithms present an effective method for solving several optimization problems from various types of applications and fields. Several metaheuristics and evolutionary optimization algorithms have been emerged recently in the literature and gained widespread attention, such as particle swarm optimization (PSO), whale optimization algorithm (WOA), grey wolf optimization algorithm (GWO), genetic algorithm (GA), and gravitational search algorithm (GSA). According to the literature, no one metaheuristic optimization algorithm can handle all present optimization problems. Hence novel optimization methodologies are still needed. The Al-Biruni earth radius (BER) search optimization algorithm is proposed in this paper. The proposed algorithm was motivated by… More >

Siti Zulaikha Mohd Jamaludin¹, Mohd. Asyraf Mansor², Aslina Baharum^3,*, Mohd Shareduwan Mohd Kasihmuddin¹, Habibah A. Wahab⁴, Muhammad Fadhil Marsani¹

CMC-Computers, Materials & Continua, Vol.74, No.2, pp. 2853-2870, 2023, DOI:10.32604/cmc.2023.032654

Abstract The effectiveness of the logic mining approach is strongly correlated to the quality of the induced logical representation that represent the behaviour of the data. Specifically, the optimum induced logical representation indicates the capability of the logic mining approach in generalizing the real datasets of different variants and dimensions. The main issues with the logic extracted by the standard logic mining techniques are lack of interpretability and the weakness in terms of the structural and arrangement of the 2 Satisfiability logic causing lower accuracy. To address the issues, the logical permutation serves as an alternative mechanism that can enhance the… More >

Rui Jiang^1,3,*, Kaisheng Lai², Jianping Xu¹, Xiang Feng¹, Shaoye Wang¹, Xiaojian Wang³, Zhe Liu²

Congenital Heart Disease, Vol.17, No.6, pp. 675-686, 2022, DOI:10.32604/chd.2022.021626

Abstract Background: The etiology of pulmonary arterial hypertension associated with congenital heart disease (PAHCHD) is complicated and the phenotype is heterogeneous. Genetic defects of NOTCH3 were associated with cerebral disease and pulmonary hypertension. However, the relationship between NOTCH3 mutations and the clinical phenotype has not been reported in CHD-PAH. Methods: We eventually enrolled 142 PAH-CHD patients from Fuwai Hospital. Whole exome sequencing (WES) was performed to screen the rare deleterious variants of NOTCH3 gene. Results: This PAH-CHD cohort included 43 (30.3%) men and 99 (69.7%) women with the mean age 29.8 ± 10.9 years old. The pathogenic or likely pathogenic mutations… More >

T. Edwin Ponraj^1,*, J. Charles²

Intelligent Automation & Soft Computing, Vol.36, No.1, pp. 1189-1203, 2023, DOI:10.32604/iasc.2023.033383

Abstract The mutation is a critical element in determining the proteins’ stability, becoming a core element in portraying the effects of a drug in the pharmaceutical industry. Doing wet laboratory tests to provide a better perspective on protein mutations is expensive and time-intensive since there are so many potential mutations, computational approaches that can reliably anticipate the consequences of amino acid mutations are critical. This work presents a robust methodology to analyze and identify the effects of mutation on a single protein structure. Initially, the context in a collection of words is determined using a knowledge graph for feature selection purposes.… More >

LIPING GONG¹, MING JIA^2,*

BIOCELL, Vol.47, No.1, pp. 109-123, 2023, DOI:10.32604/biocell.2023.024620

Abstract ATP binding cassette subfamily C member 8 (ABCC8) encodes a protein regulating the ATP-sensitive potassium channel. Whether the level of ABCC8 mRNA in lower grade glioma (LGG) correlates with immune cell infiltration and patient outcomes has not been evaluated until now. Comparisons of ABCC8 expression between different tumors and normal tissues were evaluated by exploring publicly available datasets. The association between ABCC8 and tumor immune cell infiltration, diverse gene mutation characteristics, tumor mutation burden (TMB), and survival in LGG was also investigated in several independent datasets. Pathway enrichment analysis was conducted to search for ABCC8-associated signaling pathways. Through an online… More >

YINGHUI GAO, DENGTAI WEN^*, SHIJIE WANG, JINGFENG WANG

BIOCELL, Vol.47, No.1, pp. 41-49, 2023, DOI:10.32604/biocell.2022.022689

Abstract Presenilin (Psn) protein is associated with organismal aging. Mutations in the Psn gene may lead to Alzheimer’s disease (AD), dilated cardiomyopathy (DCM), and many age-dependent degenerative diseases. These diseases seriously affect the quality of life and longevity of the population and place a huge burden on health care and economic systems around the world. Humans have two types of Psn, presenilin-1 (PSEN1) and presenilin-2 (PSEN2). Mutations in the genes encoding PSEN1, PSEN2, and amyloid precursor protein (APP) have been identified as the major genetic causes of AD. Psn is a complex gene strongly influenced by genetic and environmental factors. The… More >

Zakir Hussain Ahmed^1,*, Naif Al-Otaibi¹, Abdullah Al-Tameem², Abdul Khader Jilani Saudagar²

CMC-Computers, Materials & Continua, Vol.74, No.1, pp. 1575-1605, 2023, DOI:10.32604/cmc.2023.031325

Abstract We study the capacitated vehicle routing problem (CVRP) which is a well-known NP-hard combinatorial optimization problem (COP). The aim of the problem is to serve different customers by a convoy of vehicles starting from a depot so that sum of the routing costs under their capacity constraints is minimized. Since the problem is very complicated, solving the problem using exact methods is almost impossible. So, one has to go for the heuristic/metaheuristic methods and genetic algorithm (GA) is broadly applied metaheuristic method to obtain near optimal solution to such COPs. So, this paper studies GAs to find solution to the… More >

Elio Caruso^1,*, Silvia Farruggio¹, Alfredo Di Pino¹, Paolo Guccione¹, Mohammadrafie Khorgami²

Congenital Heart Disease, Vol.17, No.5, pp. 551-556, 2022, DOI:10.32604/chd.2022.023711

Abstract We present the case of an infant admitted to our department for a rapid broad complex tachycardia and cardiovascular collapse. The patient was submitted to genetic testing because of a conduction defect at baseline ECG and family history of gene mutation. A new SCN5A gene mutation variant was found leading to diagnosis of sodium-channel dysfunction arrhythmia. More > Graphic Abstract

T. Jagadesh^1,2, B. Sheela Rani^3,*

Computer Systems Science and Engineering, Vol.44, No.3, pp. 2569-2583, 2023, DOI:10.32604/csse.2023.027239

Abstract RSs (Radar Systems) identify and trace targets and are commonly employed in applications like air traffic control and remote sensing. They are necessary for monitoring precise target trajectories. Estimations of RSs are non-linear as the parameters TDEs (time delay Estimations) and Doppler shifts are computed on receipt of echoes where EKFs (Extended Kalman Filters) and UKFs (Unscented Kalman Filters) have not been examined for computations. RSs, certain times result in poor accuracies and SNRs (low signal to noise ratios) especially, while encountering complicated environments. This work proposes IUKFs (Iterated UKFs) to track online filter performances while using optimization techniques to… More >

G. Rajasekaran^1,*, J. Raja Sekar²

Intelligent Automation & Soft Computing, Vol.35, No.2, pp. 2399-2412, 2023, DOI:10.32604/iasc.2023.029119

Abstract Abnormal behavior detection is challenging and one of the growing research areas in computer vision. The main aim of this research work is to focus on panic and escape behavior detections that occur during unexpected/uncertain events. In this work, Pyramidal Lucas Kanade algorithm is optimized using EMEHOs to achieve the objective. First stage, OPLKT-EMEHOs algorithm is used to generate the optical flow from MIIs. Second stage, the MIIs optical flow is applied as input to 3 layer CNN for detect the abnormal crowd behavior. University of Minnesota (UMN) dataset is used to evaluate the proposed system. The experimental result shows… More >