Ya-Sian Chang^*†‡§, Chieh-Min Chang^†‡, Chien-Yu Lin^¶#, Dy-San Chao^†, Hsi-Yuan Huang^†, Jan-Gowth Chang^{*†‡**††}

Oncology Research, Vol.28, No.2, pp. 107-116, 2020, DOI:10.3727/096504019X15698362825407

Abstract The genomic landscape of breast cancer (BC) is complex. The purpose of this study was to decipher the mutational profiles of Taiwanese patients with BC using next-generation sequencing. We performed whole-exome sequencing on DNA from 24 tumor tissue specimens from BC patients. Sanger sequencing was used to validate the identified variants. Sanger sequencing was also performed on paired adjacent nontumor tissues. After genotype calling and algorithmic annotations, we identified 49 deleterious variants in canonical cancer-related genes in our BC cohort. The most frequently mutated genes were PIK3CA (16.67%), FKBP9 (12.5%), TP53 (12.5%), ATM (8.33%), CHEK2 (8.33%), FOXO3 (8.33%), NTRK1… More >

Nikhil Gadewal^*1, Rohit Kumar^†1, Swapnil Aher^†, Anagha Gardane^†, Tarang Gaur^†, Ashok K. Varma^*‡§, Navin Khattry^¶, Syed K. Hasan^†§¶

Oncology Research, Vol.28, No.3, pp. 321-330, 2020, DOI:10.3727/096504020X15816752427321

Abstract Acute myeloid leukemia (AML) with NPM1 mutation is a disease driving genetic alteration with good prognosis. Although it has been suggested that NPM1 mutation induces chemosensitivity in leukemic cells, the underlying cause for the better survival of NPM1 mutated patients is still not clear. Mutant NPM1 AML has a unique microRNA and their target gene (mRNA) signature compared to wild-type NPM1. Dynamic regulation of miRNA–mRNA has been reported to influence the prognostic outcome. In the present study, in silico expression data of miRNA and mRNA in AML patients was retrieved from genome data commons, and differentially expressed miRNA and mRNA… More >

Yudie Yang^*1, Xia Zhang^†1, Yajie Gao^*, Yan Dong^*, Di Wang^*, Yanping Huang^*, Tianhao Qu^*, Buqun Fan^*, Qizheng Li^*, Chunxia Zhang^*, Xiaonan Cui^*, Bin Zhang^*

Oncology Research, Vol.29, No.1, pp. 63-74, 2021, DOI:10.3727/096504022X16462176651719

Abstract Lung cancer is a malignant tumor with high incidence and mortality across the world. The use of immune checkpoint inhibitors for lung cancer has improved the prognosis of some lung cancer patients to a greater extent and provided a new direction for the clinical treatment of lung cancer. Immunotherapy still has limitations in terms of its appropriate population and adverse reactions. Particularly for non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutation, there has been no major breakthrough in current immunotherapy. Whether immunotherapy can bring new benefits after drug resistance is induced by tyrosine kinase inhibitor-targeted… More >

V. Premanand^*, Dhananjay Kumar

Computer Systems Science and Engineering, Vol.44, No.2, pp. 1807-1821, 2023, DOI:10.32604/csse.2023.026742

Abstract On grounds of the advent of real-time applications, like autonomous driving, visual surveillance, and sports analysis, there is an augmenting focus of attention towards Multiple-Object Tracking (MOT). The tracking-by-detection paradigm, a commonly utilized approach, connects the existing recognition hypotheses to the formerly assessed object trajectories by comparing the similarities of the appearance or the motion between them. For an efficient detection and tracking of the numerous objects in a complex environment, a Pearson Similarity-centred Kuhn-Munkres (PS-KM) algorithm was proposed in the present study. In this light, the input videos were, initially, gathered from the MOT dataset and converted into frames.… More >

Pranav Pushkar¹, Christo Ananth², Preeti Nagrath¹, Jehad F. Al-Amri⁵, Vividha¹, Anand Nayyar^3,4,*

CMC-Computers, Materials & Continua, Vol.73, No.1, pp. 1601-1619, 2022, DOI:10.32604/cmc.2022.026205

Abstract The study of viruses and their genetics has been an opportunity as well as a challenge for the scientific community. The recent ongoing SARS-Cov2 (Severe Acute Respiratory Syndrome) pandemic proved the unpreparedness for these situations. Not only the countermeasures for the effect caused by virus need to be tackled but the mutation taking place in the very genome of the virus is needed to be kept in check frequently. One major way to find out more information about such pathogens is by extracting the genetic data of such viruses. Though genetic data of viruses have been cultured and stored as… More >

LIANGYING ZHANG¹, SHAOTING ZHANG¹, ZHAOYANG FAN¹, ZONGYING JIANG^1,2, ANBU LIU¹, SHUJING LI^1,2, JIANMIN SUN^1,*

BIOCELL, Vol.46, No.9, pp. 2081-2087, 2022, DOI:10.32604/biocell.2022.020109

Abstract PI3 kinases are important for KIT signaling and KIT mutants mediated cell transformation. In order to know the difference of PI3 kinase isoforms p110α and p110δ in the signaling of wild-type KIT and the often occurred KIT mutation D816V in hematopoietic malignancy mastocytosis, the predominant PI3 kinase isoform p110δ in hematopoietic tissues was knocked out in hematopoietic cells. We found that loss of p110δ expression dramatically inhibits PI3 kinase activation mediated by both wild-type KIT and KIT/D816V. By over expression of p110α in p110δ knock out cells, wild-type KIT mediated PI3 kinase activation was not changed while over expression of… More >

XIAOXIA WANG^1,#, ZHONGYUAN YAO^1,2,#, DI LIU¹, CHUNHONG YU^3,*, HUI LI^1,3,*

BIOCELL, Vol.46, No.8, pp. 1803-1806, 2022, DOI:10.32604/biocell.2022.019731

Abstract Each stage of embryonic development, including normal gamete maturation, fertilization, zygotic genome activation, and cleavage, is crucial for human reproduction. Early embryo arrest is a common phenomenon. It is estimated that about 40%–70% of human embryos are arrested at early developmental stages. However, the exact mechanism remains largely uncertain. Embryos can be investigated in vitro by way of the development of in vitro fertilization/intracytoplasmic sperm injection. In addition to iatrogenic factors related to abnormal oocyte/embryo development, multiple gene mutations have been found to be involved in such phenotypes. Based on the knowledge of known etiological factors, several therapies are proposed… More >

Ankur Dumka¹, Parag Verma², Rajesh Singh³, Anuj Bhardwaj⁴, Khalid Alsubhi⁵, Divya Anand^6,7,*, Irene Delgado Noya^7,8, Silvia Aparicio Obregon^7,9

CMC-Computers, Materials & Continua, Vol.72, No.3, pp. 4453-4466, 2022, DOI:10.32604/cmc.2022.023974

Abstract In December 2019, a group of people in Wuhan city of Hubei province of China were found to be affected by an infection called dark etiology pneumonia. The outbreak of this pneumonia infection was declared a deadly disease by the China Center for Disease Control and Prevention on January 9, 2020, named Novel Coronavirus 2019 (nCoV-2019). This nCoV-2019 is now known as COVID-19. There is a big list of infections of this coronavirus which is present in the form of a big family. This virus can cause several diseases that usually develop with a serious problem. According to the World… More >

Elsa Maitre, Xavier Troussard^*

Oncologie, Vol.24, No.1, pp. 3-24, 2022, DOI:10.32604/oncologie.2022.021490

Abstract Hairy cell leukemia (LT) accounts for 2% of all leukemias. The diagnosis is based on the presence in the blood and/ or the marrow of hairy cells expressing CD103, CD123, CD11c and CD25. The BRAF^V600E mutation, a molecular marker of the disease, is present in more than 80% of cases. LT should be distinguished from other chronic B-cell lymphoproliferative disorders, including the variant form of hairy cell leukemia (HCL-V) and diffuse splenic red pulp lymphoma (DSRPL). Progress has recently been made in the management of patients. The purine analogues (PNAs) in monotherapy, deoxycoformycin (DCF) or 2-chloro-deoxyadenosine (CDA), remain the first-line… More >

Jyoti Khandelwal¹, Vijay Kumar Sharma¹, Dilbag Singh^2,*, Atef Zaguia³

CMC-Computers, Materials & Continua, Vol.72, No.2, pp. 3299-3312, 2022, DOI:10.32604/cmc.2022.023116

Abstract Digital image steganography technique based on hiding the secret data behind of cover image in such a way that it is not detected by the human visual system. This paper presents an image scrambling method that is very useful for grayscale secret images. In this method, the secret image decomposes in three parts based on the pixel's threshold value. The division of the color image into three parts is very easy based on the color channel but in the grayscale image, it is difficult to implement. The proposed image scrambling method is implemented in image steganography using discrete wavelet transform… More >