Jianjun Gan^1,2, Y. X. Zhang^2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.121, No.3, pp. 981-1009, 2019, DOI:10.32604/cmes.2019.07337

Abstract This study proposes a comprehensive method, which consists of field investigation, flume test and numerical simulation, to predict the velocity and sediment thickness of debris flow. The velocity and sediment thickness of the debris flow in mountainous areas can provide critical data to evaluate the geohazard, which will in turn help to understand the debris runout. The flume test of this debris prototype can provide friction coefficient and viscosity coefficient which are important for numerical simulation of debris flow. The relation between the key parameters in the numerical modelling using the Voellmy model and debris-flow rheology is discussed. Through simulation… More >

Long Yu¹, Kesong Xu¹, Jun Wan², Haiyan Lu^3,*, Shengzhang Wang^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.121, No.3, pp. 835-844, 2019, DOI:10.32604/cmes.2019.07428

Abstract Fractional flow reserve (FFR) computed from computed tomography angiography (CTA), i.e., FFR_CT has been used in the clinic as a noninvasive parameter for functional assessment of coronary artery stenosis. It has also been suggested to be used in the assessment of carotid artery stenosis. The wall thickness of the vessel is an important parameter when establishing a fluid-structure coupling model of carotid stenosis. This work studies the effect of the vessel wall thickness on hemodynamic parameters such as FFR_CT in carotid stenosis. Models of carotid stenosis are established based on CTA image data using computer-aided design software. It is assumed… More >

Jie Bai^1,#, Liqiang Lin^1,#, Xiaowei Zeng ^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.121, No.3, pp. 787-800, 2019, DOI:10.32604/cmes.2019.07159

Abstract The collective cell migration behavior on a substrate was studied using RKPM meshfree method. The cells were modeled as nematic liquid crystal with hyperelastic cell nucleus. The cell-substrate and cell-cell interactions were modeled by coarse-grained potential forces. Through this study, the pulling and pushing phenomenon during collective cell migration process was observed and it was found that the individual cell mobility significantly influenced the collective cell migratory behavior. More self-propelled cells are in the system along the same direction, the faster the collective group migrates toward coordinated direction. The parametric study on cell-cell adhesion strength indicated that as the adhesion… More >

Yanzhuo Xue¹, Renwei Liu¹, Yang Liu^1,*, Lingdong Zeng¹, Duanfeng Han¹

CMES-Computer Modeling in Engineering & Sciences, Vol.121, No.2, pp. 523-550, 2019, DOI:10.32604/cmes.2019.06951

Abstract In this study, a numerical method was developed based on peridynamics to determine the ice loads for a ship navigating in level ice. Convergence analysis of threedimensional ice specimen with tensile and compression loading are carried out first. The effects of ice thickness, sailing speed, and ice properties on the mean ice loads were also investigated. It is observed that the ice fragments resulting from the icebreaking process will interact with one another as well as with the water and ship hull. The ice fragments may rotate, collide, or slide along the ship hull, and these ice fragments will eventually… More >

Bin Jia¹, Lei Ju^1,*, Qing Wang¹

CMES-Computer Modeling in Engineering & Sciences, Vol.121, No.2, pp. 501-522, 2019, DOI:10.32604/cmes.2019.06798

Abstract In the ice-covered oceanic region, the collision between sea ice and offshore structures will occur, causing the crushing failure of ice and the vibration of structures. The vibration can result in fatigue damage of structure and even endanger the crews’ health. It is no doubt that this ice-structure interaction has been noted with great interest by the academic community for a long time and numerous studies have been done through theoretical analysis, experimental statistics and numerical simulation. In this paper, the bond-based Peridynamics method is applied to simulate the interaction between sea ice and wide vertical structures, where sea ice… More >

Mohammadali Sharzehee¹, Yuan Chang², Jiang-ping Song², Hai-Chao Han^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 16-17, 2019, DOI:10.32604/mcb.2019.07129

Abstract A myocardial bridge (MB), a congenital anomaly of the coronary artery, occurs when a segment of the epicardial coronary artery goes underneath the myocardium. MBs are often observed in the middle part of the left anterior descending (LAD) artery. MB squeezes the vessel wall periodically and induces hemodynamic abnormalities which are correlated with angina and myocardial ischemia. The level of hemodynamics disturbances induced by MB depends on the myocardial bridge length, the degree of myocardial contractility, thickness, and location [1]. Hypertrophic cardiomyopathy (HCM), characterized by abnormal thickening of the heart wall, is a leading cause of death in patients of… More >

Ram P. Ghosh¹, Matteo Bianchi¹, Gil Marom², Oren M. Rotman¹, Brandon Kovarovic¹, Danny Bluestein^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 12-14, 2019, DOI:10.32604/mcb.2019.07379

Abstract This article has no abstract. More >

Zhiguo Zhang^1,*, Chen Jiang²

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 83-84, 2019, DOI:10.32604/mcb.2019.05749

Abstract To quantitatively analyze the aerodynamic changes in patient's trachea after the resection operation of hyperplastic granulation tissue, computational fluid dynamic (CFD) method was utilized to perform the simulation. Firstly, three dimensional finite element model of the patient’s trachea before and after surgery were reconstructed based on CT images; secondly, the numerical simulation based on CFD method was performed to investigate the changes in aerodynamic changes in patient's trachea after excision. Results indicated that the dyspnea symptom was largely alleviated after the removal surgery, the abnormal morphology was obviously improved and the resistance of trachea was decreased significantly. Present research also… More >

Chunbo Jin¹, Youjun Liu^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 51-52, 2019, DOI:10.32604/mcb.2019.05728

Abstract Coronary heart disease (CHD) is one of the most common forms of heart disease, which means that coronary stenosis can cause insufficient blood supply to the heart and lead to coronary heart disease. Coronary artery bypass grafting (coronary bypass) is often used in the treatment of patients with coronary heart disease. After surgery, because the stenosis of the coronary artery is not completely occluded, the blood flow through it will compete with the blood flow of the graft, making it possible to transplant blood vessels. The blood flow is affected, reducing long-term permeability. When the coronary artery is completely stenotic,… More >

Fuyou Liang^1,*, Tianqi Wang¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 25-26, 2019, DOI:10.32604/mcb.2019.05710

Abstract Hepatic venous pressure gradient (HVPG) measurement has been increasingly accepted as a useful means for indirectly measuring portal venous pressure in patients with portal hypertension (PHT) caused by chronic liver diseases. Despite the existence of numerous studies addressing the clinical utility of HVPG measurement, it is as yet unclear how the accuracy of measured HVPG as a surrogate of portal pressure gradient (PPG) is influenced by the pathological status of the hepatic circulation that not only changes with the progression of liver disease but also differs considerably among patients. In addition, it remains unclear whether HVPGs measured in different hepatic… More >