Ralf Weiskirchen¹, Amedeo Lonardo^2,*

BIOCELL, Vol.50, No.5, 2026, DOI:10.32604/biocell.2026.076177 - 13 May 2026

Abstract Obesity is a complex chronic condition characterized by an excess of body fat that manifests in various clinical pathophenotypes, each affecting liver health differently. One significant cause of chronic liver diseases among those living with obesity is metabolic dysfunction-associated steatotic liver disease (MASLD), which is linked to one or more cardiometabolic risk factors in individuals who do not engage in harmful alcohol consumption. Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and is increasingly being associated with MASLD through intricate immunological, cellular, proinflammatory, molecular, and genetic mechanisms. In this review, we More > Graphic Abstract

Shuyu Yuan^1,#, Guoxiao Han^1,#, Huimin Qiu¹, Henan Zheng², Rongzhi Fang¹, Wangmiao Xie¹, Wangui Yu^1,*, Xiaochun Peng^1,*

BIOCELL, Vol.50, No.4, 2026, DOI:10.32604/biocell.2026.075338 - 21 April 2026

Abstract The gut microbiota plays a pivotal role in maintaining host metabolic homeostasis. Accumulating evidence has demonstrated that dysbiosis of the gut microbiota is closely associated with metabolic disorders, including obesity, type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD). These alterations affect energy harvest, bile acid and short-chain fatty acid metabolism, intestinal barrier integrity, and low-grade inflammation, thereby contributing to insulin resistance and ectopic fat accumulation. In this narrative review, we summarize current knowledge on microbiome-host interactions in metabolic diseases, with a focus on energy metabolism, immune regulation, and inflammatory pathways. We further More > Graphic Abstract

Huan Zhou¹, Jiami Jiang², Yuqing Zou¹, Jiahui Zhang^1,*, Zhiwei Yu^3,*

BIOCELL, Vol.50, No.3, 2026, DOI:10.32604/biocell.2025.073989 - 23 March 2026

Abstract Obesity-related asthma is a distinct clinical phenotype, characterized by severe respiratory symptoms, reduced responsiveness to conventional glucocorticoid therapy, and a significantly increase in disease burden. With the rising global prevalence of obesity, the number of individuals affected by obesity-related asthma is steadily growing, presenting a pressing public health issue. The pathogenesis of obesity-related asthma is multifactorial, involving a complex interplay of metabolic and immune pathways. Key mechanisms include dysregulated T-cell differentiation, pro-inflammatory macrophage polarization, oxidative stress, and altered cytokines and adipokines secretion, all contributing to airway inflammation and remodeling. Additionally, metabolic factors, such as adiposity… More >

Cheng-Hsun Chuang^1,2,3,#, Ping-Kun Tsai^3,4,5,6,#, Shih-Wen Kao^7,8, Yu-Hsun Wang^8,9,*, Chao-Bin Yeh^1,2,3,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.072875 - 30 December 2025

Abstract Background: To determine whether initiating a glucagon-like peptide-1 receptor agonist (GLP-1 RA) within 3 months of type 2 diabetes (T2DM) diagnosis alters the subsequent risk of overall and site-specific cancer and whether this association differs by baseline body-mass index (BMI). Methods: This retrospective cohort study used electronic health records from the TriNetX U.S. research network. Adults aged 20 years or older diagnosed with T2DM between 2016 and 2024 were included if they received any hypoglycemic agents within 3 months before and after diagnosis. Following 1:1 propensity score matching, both the GLP-1 RA user and non-user… More > Graphic Abstract

LICHEN XU^1,2, PAN ZHANG³, GUIQI ZHANG², ZHAOLIANG SHEN⁴, XIZHUANG BAI^1,3,*

Oncology Research, Vol.33, No.7, pp. 1797-1798, 2025, DOI:10.32604/or.2024.061279 - 26 June 2025

Abstract This article has no abstract. More >

LICHEN XU^1,2, PAN ZHANG^3,*, GUIQI ZHANG², ZHAOLIANG SHEN⁴, XIZHUANG BAI^1,3,*

Oncology Research, Vol.32, No.11, pp. 1777-1789, 2024, DOI:10.32604/or.2024.047704 - 16 October 2024

Abstract Background: Osteosarcoma (OS), recognized as the predominant malignant tumor originating from bones, necessitates an in-depth comprehension of its intrinsic mechanisms to pinpoint novel therapeutic targets and enhance treatment methodologies. The role of fat mass and obesity-associated (FTO) in OS, particularly its correlation with malignant traits, and the fundamental mechanism, remains to be elucidated. Materials and Methods: 1. The FTO expression and survival rate in tumors were analyzed. 2. FTO in OS cell lines was quantified utilizing western blot and PCR. 3. FTO was upregulated and downregulated separately in MG63. 4. The impact of FTO on the… More >

YUN WANG¹, XIAOJIANG LI², DALONG LIU², ZHIFENG WANG³, JICHEN XIA⁴, LIJUN WANG⁵, XUDONG ZHANG^6,*

Oncology Research, Vol.32, No.10, pp. 1649-1660, 2024, DOI:10.32604/or.2024.043482 - 18 September 2024

Abstract Exosomes, minute vesicles ubiquitously released by diverse cell types, serve as critical mediators in intercellular communication. Their pathophysiological relevance, especially in malignancies, has garnered significant attention. A meticulous exploration of the exosomal impact on cancer development has unveiled avenues for innovative and clinically valuable techniques. The cargo conveyed by exosomes exerts transformative effects on both local and distant microenvironments, thereby influencing a broad spectrum of biological responses in recipient cells. These membrane-bound extracellular vesicles (EVs) play a pivotal role in delivering bioactive molecules among cells and organs. Cellular and biological processes in recipient cells, ranging… More > Graphic Abstract

DANIELLA M. ADAMS¹, KALIE F. BECKERS¹, JULIET P. FLANAGAN¹, VIVIANE C. L. GOMES^1,#, CHIN-CHI LIU¹, JENNY L. SONES^1,2,*

BIOCELL, Vol.47, No.9, pp. 2051-2058, 2023, DOI:10.32604/biocell.2023.029644 - 28 September 2023

Abstract Background: Women with obesity have higher risk of adverse pregnancy outcomes, including preeclampsia (PE). Late-gestational hypertension, aberrant fetoplacental development, and fetal growth restriction (FGR), hallmarks of PE, are observed spontaneously in BPH/5 mice. Similar to obese preeclamptic women, BPH/5 mice have higher visceral white adipose tissue (WAT) and circulating leptin. We hypothesized that attenuation of maternal obesity and serum leptin in pregnant BPH/5 mice will improve fetoplacental development by decreasing hypoxia markers and leptin expression at the maternal-fetal interface. Methods: To test this hypothesis, BPH/5 mice were fed ad libitum (lib) and pair-fed (PF) to C57… More >

Saeed Ali Alsareii¹, Muhammad Awais^2,*, Abdulrahman Manaa Alamri¹, Mansour Yousef AlAsmari¹, Muhammad Irfan³, Mohsin Raza², Umer Manzoor⁴

Computer Systems Science and Engineering, Vol.46, No.3, pp. 3715-3728, 2023, DOI:10.32604/csse.2023.035687 - 03 April 2023

Abstract Obesity is a critical health condition that severely affects an individual’s quality of life and well-being. The occurrence of obesity is strongly associated with extreme health conditions, such as cardiac diseases, diabetes, hypertension, and some types of cancer. Therefore, it is vital to avoid obesity and or reverse its occurrence. Incorporating healthy food habits and an active lifestyle can help to prevent obesity. In this regard, artificial intelligence (AI) can play an important role in estimating health conditions and detecting obesity and its types. This study aims to see obesity levels in adults by implementing… More >

Saeed Ali Alsareii¹, Mohsin Raza², Abdulrahman Manaa Alamri¹, Mansour Yousef AlAsmari¹, Muhammad Irfan³, Hasan Raza⁴, Muhammad Awais^2,*

CMC-Computers, Materials & Continua, Vol.75, No.2, pp. 3833-3848, 2023, DOI:10.32604/cmc.2023.035686 - 31 March 2023

Abstract Obesity poses several challenges to healthcare and the well-being of individuals. It can be linked to several life-threatening diseases. Surgery is a viable option in some instances to reduce obesity-related risks and enable weight loss. State-of-the-art technologies have the potential for long-term benefits in post-surgery living. In this work, an Internet of Things (IoT) framework is proposed to effectively communicate the daily living data and exercise routine of surgery patients and patients with excessive weight. The proposed IoT framework aims to enable seamless communications from wearable sensors and body networks to the cloud to create More >