Saeed Ali Alsareii¹, Muhammad Awais^2,*, Abdulrahman Manaa Alamri¹, Mansour Yousef AlAsmari¹, Muhammad Irfan³, Mohsin Raza², Umer Manzoor⁴

Computer Systems Science and Engineering, Vol.46, No.3, pp. 3715-3728, 2023, DOI:10.32604/csse.2023.035687 - 03 April 2023

Abstract Obesity is a critical health condition that severely affects an individual’s quality of life and well-being. The occurrence of obesity is strongly associated with extreme health conditions, such as cardiac diseases, diabetes, hypertension, and some types of cancer. Therefore, it is vital to avoid obesity and or reverse its occurrence. Incorporating healthy food habits and an active lifestyle can help to prevent obesity. In this regard, artificial intelligence (AI) can play an important role in estimating health conditions and detecting obesity and its types. This study aims to see obesity levels in adults by implementing… More >

Saeed Ali Alsareii¹, Mohsin Raza², Abdulrahman Manaa Alamri¹, Mansour Yousef AlAsmari¹, Muhammad Irfan³, Hasan Raza⁴, Muhammad Awais^2,*

CMC-Computers, Materials & Continua, Vol.75, No.2, pp. 3833-3848, 2023, DOI:10.32604/cmc.2023.035686 - 31 March 2023

Abstract Obesity poses several challenges to healthcare and the well-being of individuals. It can be linked to several life-threatening diseases. Surgery is a viable option in some instances to reduce obesity-related risks and enable weight loss. State-of-the-art technologies have the potential for long-term benefits in post-surgery living. In this work, an Internet of Things (IoT) framework is proposed to effectively communicate the daily living data and exercise routine of surgery patients and patients with excessive weight. The proposed IoT framework aims to enable seamless communications from wearable sensors and body networks to the cloud to create More >

LING SHENG^1,2, YUEHONG SHEN^1,2, HONGYU YANG^1,2,*

BIOCELL, Vol.46, No.11, pp. 2387-2397, 2022, DOI:10.32604/biocell.2022.021032 - 07 July 2022

Abstract N⁶-methyladenosine (m⁶A) modification is the most widespread and conserved internal mRNA modification in mammalian cells. It greatly affects genetic regulation by enhancing the involvement of diverse cellular enzymes and thus, plays a significant role in basic life processes. Numerous studies on m⁶A modification identified FTO as a crucial demethylase that participates in various biological processes. Not only does FTO play a pivotal role in obesity-related conditions, but it also influences the occurrence, development, and prognosis of several cancers, such as acute myeloid leukemia, breast cancer, liver cancer, and lung cancer. Moreover, FTO also shows a close association More >

MIN CHEN^1,#, YUAN HUANG^2,#, WEN XU², CHUNLIN SU^2,*

BIOCELL, Vol.46, No.6, pp. 1505-1519, 2022, DOI:10.32604/biocell.2022.016564 - 07 February 2022

Abstract The development of polycystic ovary syndrome (PCOS) is closely related to the chronic inflammatory and obese. Recent studies have found macrophages regulate the chronic inflammation and adipose tissue remodelling, but the underlying mechanisms have not been clarified. In this study, we established a model of PCOS in the offspring rats by high androgen exposure during late pregnancy in parental and established a female rat macrophage eliminating model by rejection of clodronate liposome. Then, the offspring rat macrophage phenotype in offspring female rat adipose tissue, and levels of testosterone, angiogenic factors (PDGF and VEGF) and inflammatory… More >

KATARINA BARALIć^1,*, KATARINA ŽIVANčEVIć¹, DRAGICA BoŽIĆ¹, DANYEL JENNEN², ALEKSANDRA BUHA DJORDJEVIC¹, EVICA ANTONIJEVIć MILJAKOVIć¹, DANIJELA ĐUKIć-ĆOSIć¹

BIOCELL, Vol.46, No.2, pp. 519-533, 2022, DOI:10.32604/biocell.2022.018271 - 20 October 2021

Abstract This in silico toxicogenomic study aims to explore the relationship between phthalates and bisphenol A (BPA) co-exposure and obesity, as well as its comorbid conditions, in order to construct a possible set of genomic biomarkers. The Comparative Toxicogenomics Database (CTD; http://ctd.mdibl.org) was used as the main data mining tool, along with GeneMania (https://genemania.org), ToppGene Suite (https://toppgene.cchmc.org) and DisGeNET (http://www.disgenet.org). Among the phthalates, bis(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP) were chosen as the most frequently curated phthalates in CTD, which also share similar mechanisms of toxicity. DEHP, DBP and BPA interacted with 84, 90 and 194… More >

Jacek Karczewski^1,4, Aleksandra Zielin´ska², Rafał Staszewski³, Piotr Eder⁴, Agnieszka Dobrowolska⁴

European Cytokine Network, Vol.32, No.4, pp. 64-72, 2021, DOI:10.1684/ecn.2021.0474

Abstract The abnormal accumulation of visceral adipose tissue in obesity is associated with metabolic changes that include altered glucose tolerance, insulin resistance, hyperlipidemia, and metabolic syndrome. Obesity also coincides with increased incidence of autoimmune diseases. Accumulating evidence suggest that prolonged metabolic overload related to overnutrition, influenced by genetic and epigenetic factors, might affect immunologic self-tolerance through changes in the energy metabolism of immune cells, particularly regulatory T (Treg) cells. A strong activation of nutrient-energy signaling pathways blocks the induction of the transcription factor forkhead P3 (FOXP3), a master regulator of Treg cells, consequently inhibiting their generation More >

Eda Dokumacioglu¹, Hatice Iskender¹, Arzu Sahin², Emine Yurdakul Erturk³, Ozgur Kaynar⁴

European Cytokine Network, Vol.31, No.1, pp. 39-43, 2020, DOI:10.1684/ecn.2020.0444

Abstract Background: Along with the developing technology in the modern age, physical activity had decreased considerably in children and adolescents alike with a concomitant and rapid increase in the prevalence of childhood obesity. The purpose of the present study is to measure the levels of serum nesfatin-1 and irisin in obese children. Methods: The present study was carried out with a total of 62 children, including 32 obese children diagnosed between June 2017 and October 2017 and 30 healthy children. Serum nesfatin-1, irisin, SOD, MDA, fasting blood glucose, total cholesterol (TC), triglyceride (TG), HDL-C, LDL-C, aspartate… More >

Kaylee Luck, Vernon M. Pais Jr.

Canadian Journal of Urology, Vol.27, No.6, pp. 10492-10492, 2020

Abstract This article has no abstract. More >

Jordan Allen, Necole M. Streeper

Canadian Journal of Urology, Vol.27, No.6, pp. 10488-10491, 2020

Abstract Obesity is a known risk factor for recurrent nephrolithiasis and it can be challenging to provide safe surgical intervention in the super obese population. Despite high weight limits on surgical beds, these often do not take into account positioning the patient on the end of the bed for dorsal lithotomy, which can risk an unsteady bed. In addition, depending on patient habitus the leg stirrups may not accommodate. There is limited literature that discusses the technical approach for positioning super obese patients in dorsal lithotomy when the weight limit approaches or exceeds the capacity of More >

Jeremy M. Steele^1,2, Tamar J. Preminger⁴, Francine G. Erenberg², Lu Wang³, Katherine Dell², Tarek Alsaied¹, Kenneth G. Zahka²

Congenital Heart Disease, Vol.14, No.4, pp. 517-524, 2019, DOI:10.1111/chd.12754

Abstract Objectives: To determine the prevalence, age of onset, and risk factors for overweight and obesity in children with congenital heart disease (CHD).
Study Design: Children with CHD who were seen at our institution from 1996 to 2017 were studied. Patients were full-time residents of the United States and were receiving all cardiac care at our institution. Patients were categorized by age and CHD diagnosis. The date of last normal weight for age and the date of first recorded weight in the range of overweight and obese were documented.
Results: Nine hundred sixty-eight patients with CHD were included. The More >