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  • Open Access

    ARTICLE

    A prognosis model for predicting immunotherapy response of esophageal cancer based on oxidative stress-related signatures

    JING GUO1, CHANGYONG TONG1, JIANGUANG SHI1, XINJIAN LI1, XUEQIN CHEN2,*

    Oncology Research, Vol.32, No.1, pp. 199-212, 2024, DOI:10.32604/or.2023.030969

    Abstract Oxidative stress (OS) is intimately associated with tumorigenesis and has been considered a potential therapeutic strategy. However, the OS-associated therapeutic target for esophageal squamous cell carcinoma (ESCC) remains unconfirmed. In our study, gene expression data of ESCC and clinical information from public databases were downloaded. Through LASSO-Cox regression analysis, a risk score (RS) signature map of prognosis was constructed and performed external verification with the GSE53625 cohort. The ESTIMATE, xCell, CIBERSORT, TIMER, and ImmuCellAI algorithms were employed to analyze infiltrating immune cells and generate an immune microenvironment (IM). Afterward, functional enrichment analysis clarified the underlying mechanism of the model. Nomogram… More >

  • Open Access

    Anisodine hydrobromide alleviates oxidative stress caused by hypoxia/reoxygenation in human cerebral microvascular endothelial cells predominantly via inhibition of muscarinic acetylcholine receptor 4

    WENLI JIANG1,#, JUNYI SHEN1,#, XIAOQIANG DU1,#, YAN QIU1, JIAN ZHONG1, ZHI OUYANG1, BINGMEI M. FU2, YE ZENG1,*

    BIOCELL, Vol.47, No.10, pp. 2255-2263, 2023, DOI:10.32604/biocell.2023.030880

    Abstract Background: Anisodine hydrobromide (AT3), an anti-cholinergic agent, could be delivered to the brain across the blood-brain barrier and has been used clinically for the treatment of cerebral ischemia/reperfusion injury. Endothelial dysfunction can be caused by hypoxia/reoxygenation (H/R) via oxidative stress and metabolic alterations. The present study investigated whether AT3 regulates the production of nitric oxide (NO) and reactive oxygen species (ROS), and the HIF-1α pathway via regulation of muscarinic acetylcholine receptors (mAChRs) in brain microvascular endothelial cells after H/R exposure. Methods: Under H/R conditions, hCMEC/D3 cerebral microvascular endothelial cells were treated with AT3. Specific inhibitors of M2- and M4- mAChRs… More > Graphic Abstract

    Anisodine hydrobromide alleviates oxidative stress caused by hypoxia/reoxygenation in human cerebral microvascular endothelial cells predominantly via inhibition of muscarinic acetylcholine receptor 4

  • Open Access

    ARTICLE

    Seed Priming and Foliar Supplementation with β-aminobutyric Acid Alleviates Drought Stress through Mitigation of Oxidative Stress and Enhancement of Antioxidant Defense in Linseed (Linum usitatissimum L.)

    Tauqeer Ahmad Yasir1,2, Muhammad Ateeq1,3, Allah Wasaya1,2,*, Mubshar Hussain2, Naeem Sarwar2, Khuram Mubeen4, Mudassir Aziz4, Muhammad Aamir Iqbal5, Chukwuma C. Ogbaga6, Ibrahim Al-Ashkar7, Md Atikur Rahman8, Ayman El Sabagh9,10,*

    Phyton-International Journal of Experimental Botany, Vol.92, No.11, pp. 3113-3131, 2023, DOI:10.32604/phyton.2023.029502

    Abstract Drought is one of the critical limitations to agricultural soils and crop plants. Scarcity of water is increasing due to climate change that lead to increasing threats to global food security. Therefore, ecofriendly and cost effective strategies are highly desirable for mitigating drought stress along with sustainable and smart agricultural production. The aim of the study was to mitigate DS using seed priming and exogenous supplementation of β-aminobutyric acid (BABA) in linseed (Linum usitatissimum L.). Different doses (0, 50, 100 and 150 µM) of BABA were used for seed priming agent and foliar spraying under three soil moisture levels viz.,… More >

  • Open Access

    ARTICLE

    The potency of N, N'-diphenyl-1,4-phenylenediamine and adipose-derived stem cell co-administration in alleviating hepatorenal dysfunction complications associated with type 1 diabetes mellitus in rats

    HANY M. ABD EL-LATEEF1,2,*, SAFA H. QAHL3, EMAN FAYAD4, SARAH A. ALTALHI4, IBRAHIM JAFRI4, EL SHAIMAA SHABANA5, MARWA K. DARWISH6,7, REHAB MAHER8, SAAD SHAABAN1,9, SHADY G. EL-SAWAH10,*

    BIOCELL, Vol.47, No.8, pp. 1885-1895, 2023, DOI:10.32604/biocell.2023.030680

    Abstract Background: The increasing occurrence of diabetes mellitus (DM) noted worldwide has considerably elicited concern in the recent past. DM is associated with elevated vascular complications, morbidity, mortality, and poor quality of life. In this context, mesenchymal stem cells (MSCs) have shown significant therapeutic potentialities in managing and curing type 1 DM owing to their self-renewable, immunosuppressive, and differentiation capacities. We investigated the potential action of N, N′-diphenyl-1,4-phenylenediamine (DPPD), a well-known synthetic antioxidant to enhance the therapeutic ability of the adipose-derived stem cells (AD-MSCs) in alleviating kidney and liver complications in diabetic rats. Methods: Over the four weeks of experiments, albino… More > Graphic Abstract

    The potency of <i>N</i>, <i>N'</i>-diphenyl-1,4-phenylenediamine and adipose-derived stem cell co-administration in alleviating hepatorenal dysfunction complications associated with type 1 diabetes mellitus in rats

  • Open Access

    REVIEW

    Breaking Barriers: Selenium and Silicon-Mediated Strategies for Mitigating Abiotic Stress in Plants

    Mojtaba Kordrostami1, Ali Akbar Ghasemi-Soloklui1, Mohammad Anwar Hossain2,*, Mohammad Golam Mostofa3,4,*

    Phyton-International Journal of Experimental Botany, Vol.92, No.9, pp. 2713-2736, 2023, DOI:10.32604/phyton.2023.030372

    Abstract Numerous plant species, particularly those that can accumulate selenium (Se) and silicon (Si), benefit from these essential micronutrients. Se and Si accumulation in plants profoundly affects several biochemical reactions in cells. Understanding how plants react to Se/Si enrichment is crucial for ensuring adequate dietary Se/Si intake for humans and animals and increasing plant tolerance to environmental stressors. Several studies have shown that Se/Si-enriched plants are more resistant to salinity, drought, extreme temperatures, UV radiation, and excess metalloids. The interplay between Se/Si in plants is crucial for maintaining growth and development under normal conditions while providing a critical defense mechanism against… More >

  • Open Access

    REVIEW

    A Review on Selenium Function under Oxidative Stress in Plants Focusing on ROS Production and Detoxification

    Armin Saed-Moucheshi1,*, Elham Rezaei Mirghaed2

    Phyton-International Journal of Experimental Botany, Vol.92, No.7, pp. 1921-1941, 2023, DOI:10.32604/phyton.2023.027810

    Abstract

    One of the main reasons of the annual reduction in plant production all around the world is the occurrence of abiotic stresses as a result of an unpredicted changes in environmental conditions. Abiotic stresses basically trigger numerous pathways related to oxygen free radicals’ generation resulting in a higher rate of reactive oxygen species (ROS) production. Accordingly, higher rate of oxygen free radicals than its steady state causes to oxidize various types of molecules and compartments within the plants’ cells and tissues. Oxidative stress is the result of high amount free radicals of oxygen interfering with different functions leading to undergo… More >

  • Open Access

    ARTICLE

    Inhibition of H2O2-induced TM3 cell apoptosis by oxidative stress by lentinan functionalized selenium nanoparticles through JAK2/STAT-3 and P53 pathways

    MIAOMIAO LI1,#, ZILIN ZHENG1,#, JUNYI KE1, JIEYI LUO1, FAN JIANG1, YANXIA QU1, BING ZHU2, YINGHUA LI2,*, LIANDONG ZUO1,*

    BIOCELL, Vol.47, No.6, pp. 1397-1405, 2023, DOI:10.32604/biocell.2023.027971

    Abstract Background: Nano-selenium has been widely used in antiviral and anticancer therapy, and has the advantages of good targeting and low toxicity. For the first time, we combined male reproduction with nano-selenium to investigate its antioxidant effect. This study investigated the protective effect of lentinan functionalized selenium nanoparticles on oxidative stress injury of the hydrogen peroxide (H2O2)-induced Leydig cell line, TM3. Methods: The suitable concentration of nano-selenium treatment to promote cell proliferation was also discussed. The concentration of 4 μM could significantly promote the growth of TM3 cells. Oxidative stress damage was caused using an 800 μM concentration of hydrogen peroxide.… More >

  • Open Access

    ARTICLE

    Cd and Hg Mediated Oxidative Stress, Antioxidative Metabolism and Molecular Changes in Soybean (Glycine max L.)

    Sheeba Naaz1,2, Nadeem Ahmad2, Asma A. Al-Huqail3, Mohammad Irfan4, Faheema Khan3, Mohammad Irfan Qureshi1,*

    Phyton-International Journal of Experimental Botany, Vol.92, No.6, pp. 1725-1742, 2023, DOI:10.32604/phyton.2023.026100

    Abstract Cadmium (Cd) and Mercury (Hg) is among the heavy metals most hazardous for plant and human health. Known to induce oxidative stress in plants and disbalance equilibrium in the antioxidant defence system, these metals alter plant growth and cause damage at the cellular and molecular levels. Soybean is an important oilseed crop that is raised in soils often contaminated by Cd and Hg. The comparative studies on the deleterious effect of Cd and Hg and the defence system of antioxidants were not studied earlier in soybean plant. In this study, soybean plants were exposed to Cd (100 µM CdCl2) and… More >

  • Open Access

    REVIEW

    Fe-dependent cellular alterations of oxidative balance in aquatic organisms. Could be ferroptosis involved?

    PAULA MARIELA GONZÁLEZ1,2, JOAQUIN CABRERA1,2, SUSANA PUNTARULO1,2,*

    BIOCELL, Vol.47, No.5, pp. 1177-1189, 2023, DOI:10.32604/biocell.2023.027107

    Abstract

    The purpose of this review is to briefly summarize the central role of iron (Fe) in terms of cellular alterations of the oxidative/protective balance with special emphasis on its possible involvement in ferroptosis-dependent disruption in aquatic organisms. In ferroptotic cells or tissues, the intracellular Fe level increases; meanwhile the treatment with Fe chelators limits ferroptosis. Eukaryotic algae can assimilate Fe from the environment through several mechanisms, and aquatic animals incorporate dissolved Fe and Fe bound to both inorganic particles and organic matter. The central role of lipid peroxidation mediating ferroptosis was demonstrated in some algae where both low and high… More >

  • Open Access

    ARTICLE

    The synergistic effects of PRDX5 and Nrf2 on lung cancer progression and drug resistance under oxidative stress in the zebrafish models

    SITONG QIAN1,2,#, YING FANG1,#, CHENGYUN YAO1,#, YONGSHENG WANG3,#, ZHI ZHANG1, XIAOHUA WANG1, JIN GAO1, YONG FENG1, LEI SUN1, RUNYUE ZOU2, GUOREN ZHOU1,*, JINJUN YE1,*, RUIXUE XIA4,*, HONGPING XIA5,6,*

    Oncology Research, Vol.30, No.2, pp. 53-64, 2022, DOI:10.32604/or.2022.026302

    Abstract Previous studies have shown that PRDX5 and Nrf2 are antioxidant proteins related to abnormal reactive oxidative species (ROS). PRDX5 and Nrf2 play a critical role in the progression of inflammations and tumors. The combination of PRDX5 and Nrf2 was examined by Co-immunoprecipitation, western blotting and Immunohistochemistry. H2O2 was applied to affect the production of ROS and induced multi-resistant protein 1 (MRP1) expression in NSCLC cells. The zebrafish models mainly investigated the synergistic effects of PRDX5 and Nrf2 on lung cancer drug resistance under oxidative stress. We showed that PRDX5 and Nrf2 form a complex and significantly increase the NSCLC tissues… More >

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