Fahad Alotaibi¹, Muhammad Attique^2,3, Yaser Daanial Khan^2,*

CMC-Computers, Materials & Continua, Vol.69, No.1, pp. 1039-1055, 2021, DOI:10.32604/cmc.2021.017297

Abstract Several autoimmune ailments and inflammation-related diseases emphasize the need for peptide-based therapeutics for their treatment and established substantial consideration. Though, the wet-lab experiments for the investigation of anti-inflammatory proteins/peptides (“AIP”) are usually very costly and remain time-consuming. Therefore, before wet-lab investigations, it is essential to develop in-silico identification models to classify prospective anti-inflammatory candidates for the facilitation of the drug development process. Several anti-inflammatory prediction tools have been proposed in the recent past, yet, there is a space to induce enhancement in prediction performance in terms of precision and efficiency. An exceedingly accurate anti-inflammatory prediction model is proposed, named AntiFlamPred… More >

Sharaf J. Malebary¹, Yaser Daanial Khan^2,*

CMC-Computers, Materials & Continua, Vol.67, No.3, pp. 2863-2881, 2021, DOI:10.32604/cmc.2021.015041

Abstract With the advancement in cellular biology, the use of antimicrobial peptides (AMPs) against many drug-resistant pathogens has increased. AMPs have a broad range of activity and can work as antibacterial, antifungal, antiviral, and sometimes even as anticancer peptides. The traditional methods of distinguishing AMPs from non-AMPs are based only on wet-lab experiments. Such experiments are both time-consuming and expensive. With the recent development in bioinformatics more and more researchers are contributing their effort to apply computational models to such problems. This study proposes a prediction algorithm for classifying AMPs and distinguishing between AMPs and non-AMPs. The proposed methodology uses machine… More >

JUN ZHANG, YEHONG HUANG, WENZHUO LIU, LULU LI, LIMING CHEN^*

BIOCELL, Vol.44, No.4, pp. 591-595, 2020, DOI:10.32604/biocell.2020.011642

Abstract Estrogen receptor alpha (ERα/ESR1) is overexpressed in over half of all breast cancers and is considered a valuable therapeutic target in ERα positive breast cancer. Here, we designed a membrane-permeant Chaperonemediated Autophagy Targeting Chimeras (CMATAC) peptide to knockdown endogenous ERα protein through chaperone-mediated autophagy. The peptide contains a cell membrane-penetrating peptide (TAT) that allows the peptide to by-pass the plasma membrane, an αI peptide as a protein-binding peptide (PBD) that binds specifically to ERα, and CMA-targeting peptide (CTM) that targeting chaperone-mediated autophagy. We validated that ERα targeting peptide was able to target and degrade ERα to reduce the viability of… More >

Siyi Fu^1,#, Tao Yun^2,#, Dexuan Ma¹, Bingsong Zheng¹, Dean Jiang³, Yi He^1,*

Phyton-International Journal of Experimental Botany, Vol.90, No.1, pp. 99-110, 2021, DOI:10.32604/phyton.2021.013262

Abstract The chloroplast NAD(P)H dehydrogenase (NDH) complex, as one of the most important photosynthesis protein complexes in thylakoid membrane, is involved in photosystem I (PSI) cyclic electron transport (CEF). Under abiotic environmental stress, the photosynthetic apparatus is susceptible to the damage caused by the strong light illumination. However, the enhancement of NDHdependent CEF could facilitate the alleviation of the damage to the photosynthetic apparatus. The NdhB subunit encoded by chloroplast genome is one of most important subunits of NDH complex and consists of 510 amino acids. Here, according to cloning ndhB from Melrose (cultivated soybean), ACC547 (wild salt-tolerant soybean), S113-6 and… More >

HAO WANG^1,2,#, FANG FANG^1,#, CHAOYI FANG¹, RUNSHENG ZHAO^1,*, SHAOXIAN WANG^1,*

BIOCELL, Vol.44, No.3, pp. 421-429, 2020, DOI:10.32604/biocell.2020.010257

Abstract Stress is an inevitable interference factor that seriously affects health. Listening to music is an economical, noninvasive, and highly accepted tool for easing stress. However, physiological studies investigating the ability of music to reduce stress in daily life are limited. We established rat models of chronic immobilization stress (CIS) to observe changes in the hypothalamic arcuate nucleus (ARC) neurons involved in the regulation of food intake and the effect of comfortable classical music exposure. Twenty-one days of stress resulted in decreased food intake and delayed body weight gain; up-regulation of leptin receptor (Ob-R), cocaine- and amphetamine-regulated transcript (CART), proopiomelanocortin (POMC),… More >

Benjamin S. Frank¹, Tracy T. Urban², Karlise Lewis², Suhong Tong³, Courtney Cassidy⁴, Max B. Mitchell⁵, Christopher S. Nichols⁶, Jesse A. Davidson¹

Congenital Heart Disease, Vol.14, No.3, pp. 446-453, 2019, DOI:10.1111/chd.12744

Abstract Objective: Patients undergoing surgical repair of aortic coarctation have a 50% risk of pathologic left ventricular remodeling (increased left ventricular mass or relative wall thickness). Endothelin 1, ST2, galectin 3, norepinephrine and B‐natriuretic pep‐ tide are biomarkers that have been associated with pathologic LV change in adult populations but their predictive value following pediatric coarctation repair are not known.
Hypothesis: Biomarker levels at coarctation repair will predict persistent left ven‐ tricular remodeling at 1‐year follow up.
Design: Prospective, cohort study of 27 patients’ age 2 days‐12 years with coarcta‐ tion of the aorta undergoing surgical repair. Echocardiograms were performed pre‐… More >

C. GAMARRA-LUQUES, B.C. WINIK, I.A. VEGA, E.A. ALBRECHT, N.M. CATALAN, A. CASTRO-VAZQUEZ

BIOCELL, Vol.30, Suppl.S, pp. 345-357, 2006

Abstract This article has no abstract. More >

Valle-Rodríguez CM¹, S Valdés-Rodríguez², NL Vasco-Méndez¹, C Garcidueñas-Piña¹, RE Soria-Guerra³, JF Morales-Domínguez¹

Phyton-International Journal of Experimental Botany, Vol.86, pp. 143-150, 2017, DOI:10.32604/phyton.2017.86.143

Abstract The natriuretic peptides (NP) are vertebrate hormones involved in the regulation of ion and water homeostasis in the cell. In plants, natriuretic peptides (PNP) have been identified by molecular and biochemical methods. It has been suggested that PNPs, have similar functions to the PN, since they mediate (1) ion transport through the cell, (2) the opening and closing of Na⁺ and K⁺ channels through the stimulation and synthesis of a second messenger such as cGMP, and (3) the aperture of stomata. In this study, a PNPs gene was partially identified by PCR in garlic (Allium sativum L.), which was called… More >

ANA LUCÍA DE PAUL^*, MÓNICA BONATERRA^*, CLAUDIA GABRIELA PELLIZAS^**, AGUSTÍN AOKI^*, ALICIA INÉS TORRES^*

BIOCELL, Vol.26, No.1, pp. 49-60, 2002, DOI:10.32604/biocell.2002.26.049

Abstract In the present study the in vivo and in vitro effects of GHRP-5 on the PRL-releasing activity in correlation with the morphological changes of lactotroph cells and their transcriptional activity were evaluated. The in vitro treatment (12 µg/100g BW/day for 3 days) of male rats with GHRP-5 does not induce any significant changes in serum PRL levels. In contrast, the addition of GHRP-5 to pituitary cell cultures increased significantly the release of PRL. This effect is enhanced in cell cultures of enriched lactotrophs, increasing significantly the secretion of PRL, the concentrations of which were 50% higher than that of untreated… More >

Mahmoud MOUSTAFA^1,2 , Saad ALAMRI¹, Tarek TAHA³, Ali SHATI¹, Sulaiman ALRUMMAN¹, Mohamed ALKAHTANI¹

BIOCELL, Vol.43, No.3, pp. 155-166, 2019, DOI:10.32604/biocell.2019.06814

Abstract The aim of the current research was to clone and to characterize the partial 66 kDa streptavidin-binding peptide (SBP) found in the germinated embryos of Pisum sativum L. var. Alaska. The pea (P. sativum var. Alaska) embryos possess prominent 66 kDa SBPs that gradually disappeared after few hours of germination in germinated embryos, but not in the cotyledons. The total RNA was isolated from embryos of P. sativum but could not be isolated from the cotyledons. The partial nucleotides sequences of 66 kDa SBPs of embryonic stalk (P. sativum var. Alaska) were cloned and identified using pMOSBlue vector. 66 kDa… More >