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Search Results (12)
  • Open Access

    REVIEW

    Curcumin in inflammatory bowel diseases: Cellular targets and molecular mechanisms

    AMYLLY SANUELLY DA PAZ MARTINS1,#, MARLA DE CERQUEIRA ALVES2,#, ORLANDO ROBERTO PIMENTEL DE ARAÚJO3, FABIANA OLIVEIRA DOS SANTOS CAMATARI4, MARÍLIA OLIVEIRA FONSECA GOULART1,3,5, FABIANA ANDRÉA MOURA2,6,*

    BIOCELL, Vol.47, No.11, pp. 2547-2566, 2023, DOI:10.32604/biocell.2023.043253

    Abstract

    Curcumin, a natural product, has exhibited promising effects in both animal models and clinical trials, interacting with a multitude of factors linked to Inflammatory Bowel Disease (IBD). These factors encompass cytokines, oxidative stress-associated enzymes, and modulation of the intestinal microbiota. Notably, curcumin has demonstrated therapeutic potential in animal models of colitis, wherein it exerts a negative regulatory influence on pivotal signaling pathways such as PI3/Akt, JAK/STAT, and β-catenin. Moreover, it inhibits the expression of pro-inflammatory enzymes and co-stimulatory molecules (including RANKL, ICAM-1, CD205, CD256, TLR4, among others), while curbing immune cell chemotaxis, thereby attenuating the characteristic neutrophil infiltration observed in… More > Graphic Abstract

    Curcumin in inflammatory bowel diseases: Cellular targets and molecular mechanisms

  • Open Access

    ARTICLE

    Polyphenolic Compounds and Antioxidant Activity of Sea Buckthorn (Hippophae rhamnoides L.)

    Ain Raal1,*, Linda Rusalepp2, Tatiana Chiru3, Nicolae Ciobanu3, Kelly Talvistu1, Michelle Shusta1, Oleh Koshovyi1,4, Tõnu Püssa2

    Phyton-International Journal of Experimental Botany, Vol.92, No.11, pp. 2965-2979, 2023, DOI:10.32604/phyton.2023.042723

    Abstract The fruits of the Sea buckthorn (Hippophae rhamnoides L.) are a popular plant food and a valuable health product. Cultivating plants produces a lot of leaves with fine branches as an unnecessary residue, which needs valorization. The aim of the study was to estimate (by HPLC-MS/MS) the qualitative and quantitative content of polyphenolic compounds in different parts of H. rhamnoides (HR), and to determine the level of antioxidant activity of leaves and fruits (by DPPH, ABTS methods and ferrozine test). Up to 19 compounds were identified in different parts of HR. The fruits are rich in flavonoids, including various glycosides… More >

  • Open Access

    ARTICLE

    Impact of ZnSO and ZnO Nanoparticles on Seed Germination and Seedling Growth of Lettuce

    Adalberto Benavides-Mendoza1, Rebeca Betancourt-Galindo2, Nazario Francisco-Francisco3,*

    Phyton-International Journal of Experimental Botany, Vol.92, No.6, pp. 1831-1840, 2023, DOI:10.32604/phyton.2023.028085

    Abstract

    Micronutrient nanoparticles (NPs) are currently an option for chemical fertilization and biostimulation in crops. However, there is little information on the phytotoxic or biostimulatory effects of NPs at low concentrations of some elements, such as Zn. In this study, the effect of low concentrations of Zn oxide (ZnO) NPs on germination, growth variables, and nutritional attributes of lettuce (Lactuca sativa L.) was evaluated in comparison to Zn sulfate. Romaine lettuce seeds were treated with ZnSO4-- × 7H2O and ZnO NPs at Zn molar concentrations of 1 × 10−3, 5 × 10−3, 1 × 10−4, 5 × 10−4, 1… More >

  • Open Access

    ARTICLE

    Thermally Stable Polymers of Cardanol as Char-Forming Additives for Polypropylene

    Weeradech Kiratitanavit1, Sethumadhavan Ravichandran2,Zhiyu Xia1, Jayant Kumar3,4, Ramaswamy Nagarajan1,4,*

    Journal of Renewable Materials, Vol.1, No.4, pp. 289-301, 2013, DOI:10.7569/JRM.2013.634126

    Abstract Globally, certain types of halogenated fl ame retardant additives (FR) are becoming increasingly regulated or banned from being used in polymers. There is an immediate need for alternative non-toxic thermally stable polymers and char-forming additives. Development of non-halogenated FR for the commonly used and highly fl ammable thermoplastics, namely polyolefi ns, is particularly important and challenging. This research explores the possibility of utilizing char-forming compounds based on polymer of cardanol as an additive that can lower the heat release capacity (HRC) when blended with polypropylene (PP). Polycardanol is thermally stable and exhibits moderate HRC upon thermal decomposition and forms a… More >

  • Open Access

    REVIEW

    Recent Technologies for the Extraction and Separation of Polyphenols in Different Plants: A Review

    Yingying Hu1,#, Bowen Yan1,#, Zhefan Stephen Chen2, Lei Wang3, Wei Tang1 and Caoxing Huang1,*

    Journal of Renewable Materials, Vol.10, No.6, pp. 1471-1490, 2022, DOI:10.32604/jrm.2022.018811

    Abstract Polyphenol is an important secondary metabolite with unique physiological functions and biological activity. The polyphenols in different plants and biomass have different chemical structures, which needs various extraction methods to obtain them. Recently, plant polyphenols and their application research in food and medicine have become a research hotspot, which is mainly focused on preparation, purification, structural identification, and biological activity assays. Among these researches, extraction and separation are the key sections to investigate the structure and activity of polyphenol. Hence, this review summarized the recent extraction and separation techniques of polyphenol, including solvent extraction, supercritical fluid extraction, ultrasonic extraction, enzymatic… More > Graphic Abstract

    Recent Technologies for the Extraction and Separation of Polyphenols in Different Plants: A Review

  • Open Access

    ARTICLE

    Ameliorative Role of Pre-Sowing Proline Treatment in Coriandrum sativum L. Seedlings under Mercury Toxicity

    Dhriti Kapoor1, Kapani Kavani1, Amandeep Rattan2, Marco Landi3,*, Anket Sharma4,*

    Phyton-International Journal of Experimental Botany, Vol.90, No.2, pp. 489-501, 2021, DOI:10.32604/phyton.2021.012359

    Abstract Heavy metal toxicity is one of the major ecosystem concerns globally in present time and is also responsible for significant threat to agronomic crops. The current work was conducted to investigate the possible ameliorative role of proline in Coriandrum sativum L. seedlings treated with mercury (Hg). The seedlings were exposed to different concentrations of Hg (0, 0.1, 0.3 and 0.5 mM) for 20 days. The effects of pre-sowing treatment with proline were studied on C. sativum seedlings in terms of pigment (chlorophylls, carotenoids and anthocyanins), malondialdehyde (MDA), antioxidant compound (glutathione, total phenolic compounds, ascorbic acid) and osmolytes (proline, glycine betaine).… More >

  • Open Access

    ARTICLE

    Fractions of a chloroform extract of ajenjo leaves (Artemisia mendozana DC. var. mendozana) inhibit the proliferation, viability and clonogenicity of B16-F0 melanoma cells

    MARÍA ELISA MILLÁN1, MARÍA FERNANDA MARRA1, LEONARDO ANDRÉS SALVARREDI1,2,3, EMILIO FERNANDO LIZARRAGA4,*, LUIS ALBERTO LOPEZ1,*

    BIOCELL, Vol.44, No.3, pp. 293-299, 2020, DOI:10.32604/biocell.2020.012342

    Abstract The ajenjo, Artemisia mendozana DC. var. mendozana (Asteraceae), grows in the Andean foothills of Mendoza and San Juan, Argentina, and is used as a medicinal plant for its antispasmodic and antifungal properties. The aim of this work was to obtain fractions of a chloroform extract of ajenjo leaves and to evaluate the in vitro effects on proliferation, viability and clonogenicity of B16-F0 melanoma cells. Using a silica gel chromatography column, 120 fractions were collected and grouped according to the chromatographic profile in 9 main fractions (F1–F9). Their major compounds identified were: terpenes (F1), terpenes and sesquiterpene lactones (F2–F3), sesquiterpenes (F4–F6)… More >

  • Open Access

    ARTICLE

    Polyphenolic profile of Origanum vulgare L. ssp. viridulum from Argentina

    González MD, CM Luis, PL Lanzelotti

    Phyton-International Journal of Experimental Botany, Vol.83, pp. 179-184, 2014, DOI:10.32604/phyton.2014.83.179

    Abstract Characterization of oregano in Argentina is limited. They are normally known with fancy names, but it is not possible to recognize whether they are genetically equivalent or not. This paper presents a non-volatile polyphenol study of one of the subspecies of Origanum vulgare, O. vulgare L. ssp. viridulum (Martrin-Donos) Nyman [= O. vulgare L. ssp. virens (Hoffmannsegg et Link) Ietswart]. The polyphenols 3-(3,4-dihydroxyphenyl)lactic acid, 3,4-dihydroxybenzoic acid, caffeic acid, 4-(3.4-dihydroxybenzoyloxymethyl)phenyl β-glucoside and rosmarinic acid were isolated and identified by spectroscopic analysis from leaves and inflorescences of classified material. In addition, the polyphenol profile of the hydroalcoholic extract of this oregano was… More >

  • Open Access

    ARTICLE

    Gene expression profiling of HepG2 cells after treatment with black tea polyphenols

    Jie Zhong1,#, Li Deng2,#, Yu Jiang3, Lianhong Zou3, Huabing Yuan4, Shuang-xiang Tan1,*

    BIOCELL, Vol.42, No.3, pp. 99-104, 2018, DOI:10.32604/biocell.2018.04915

    Abstract This study aimed to determine the effects of black tea polyphenols on gene expression in hepatocellular cancer cells. The total RNA from HepG2 hepatocellular cancer cells treated with black tea polyphenols was subjected to Human 14K cDNA microarray analysis. Real-time PCR and Western blot analysis were conducted to verify microarray data. Black tea polyphenols treatment at the dose of 20 mg/L, 40 mg/L or 80 mg/L for one to three days inhibited the growth of HepG2 cells in a dose and time dependent manner. A total of 48 genes showed more than two-fold change after black tea polyphenols treatment, including… More >

  • Open Access

    ARTICLE

    Total Phenols, Flavonoids and Antioxidant Activity in Annona muricata and Annona purpurea Callus Culture

    M. Y. Ovando-Domínguez1, M. C. Luján-Hidalgo1, D. González-Mendoza2, A. A. Vargas-Díaz3, N. Ruiz-Lau1,4, F. A. Gutiérrez-Miceli1, C. A. Lecona-Guzmán1,*

    Phyton-International Journal of Experimental Botany, Vol.88, No.2, pp. 139-147, 2019, DOI:10.32604/phyton.2019.06546

    Abstract Callus cultures of Annona muricata and Annona purpurea were induced in Murashige and Skoog (MS) medium supplemented with different concentrations of 1-naphthylacetic acid (NAA), 6-benzyladenine (BA) and 2,4-dichlorophenoxyacetic acid (2,4-D) utilized hypocotyls with explant. The highest percentage of callus formation was the treatment supplemented with 3 mg L-1 NAA for A. muricata (100%) while for A. purpurea in lower percentage (75%). BA stimulated the formation of shoots in all the evaluated concentrations, being the concentration of 2 mg L-1 the one that induced the greater formation of shoots for A. muricata (23 shoots/explant) and A. purpurea (28 shoots/explant). The content… More >

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