Federico Greco1,2,*, Marco Cataldo3, Valerio D’Andrea2,4, Luca Pugliese5, Andrea Panunzio6, Alessandro Tafuri6, Bruno Beomonte Zobel2,4, Carlo Augusto Mallio2,4
Canadian Journal of Urology, Vol.32, No.5, pp. 433-443, 2025, DOI:10.32604/cju.2025.068390
- 30 October 2025
Abstract Background: Radiogenomics offers a non-invasive approach to correlate imaging features with tumor molecular profiles. This study aims to identify computed tomography (CT) imaging characteristics associated with positive NIPA-like domain containing 4 (NIPAL4) expression in clear cell renal cell carcinoma (ccRCC) and to develop a radiogenomic predictive model to support personalized risk stratification. Methods: A retrospective analysis was conducted on 241 ccRCC patients from The Cancer Genome Atlas (TCGA) and The Cancer Imaging Archive (TCIA) databases. Clinical, pathological, and CT features were compared between NIPAL4-positive and NIPAL4-negative groups. A penalized logistic regression model was built to… More >