Open Access

MINI REVIEW

Role of Adipose-Derived Stem Cells Therapy in Heart Failure

Gabriel Matheus Da Silva Batista, Lucas Pina Rodrigues, Andrey Jorge Serra^*

Department of Medicine, Cardiology Division, Federal University of São Paulo, São Paulo, 040039-032, Brazil

* Corresponding Author: Andrey Jorge Serra. Email:

(This article belongs to the Special Issue: Stem Cells Therapy in Health and Disease)

BIOCELL 2025, 49(10), 1873-1885. https://doi.org/10.32604/biocell.2025.067186

Received 26 April 2025; Accepted 31 July 2025; Issue published 22 October 2025

Abstract

Adipose-derived stem cells (ADSCs) therapy has emerged as a promising strategy for treating degenerative, inflammatory, and cardiometabolic diseases. In addition to their higher bioavailability in adipose tissue, ADSCs demonstrate superior activity in producing specific immune modulators and growth factors when compared to other stem cell types. The detrimental impact of heart failure (HF)—a condition that still lacks a fully effective therapy—has driven significant interest in the therapeutic potential of ADSCs. This interest is supported by robust evidence from experimental studies employing HF animal models. Accordingly, this review aims to explore the cardioprotective mechanisms through which ADSCs may exert beneficial effects in the context of HF.

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